Prostate Cell News Volume 2.37 | Oct 7 2011

SCRIB Expression is Deregulated in Human Prostate Cancer, and Its Deficiency in Mice Promotes Prostate Neoplasia
Here, researchers report that Scrib is indispensable for prostate homeostasis in mice. Scrib heterozygosity initiated prostate hyperplasia, while targeted biallelic Scrib loss predisposed mice to prostate intraepithelial neoplasia. [J Clin Invest] Abstract

LABORATORY RESEARCH

A Role for Collagen XXIII in Cancer Cell Adhesion, Anchorage-Independence and Metastasis
To determine whether collagen XXIII facilitates cancer cell metastasis in vivo and to establish a function for collagen XXIII in cancer progression, collagen XXIII knockdown cells were examined for alterations in in vivo metastasis as well as in vitro cell adhesion. [Oncogene] Abstract

Dynamic Nucleosome Depleted Regions at Androgen Receptor Enhancers in the Absence of Ligand in Prostate Cancer Cells
Researchers investigated nucleosome positioning at the androgen receptor enhancers of TMPRSS2, KLK2 and KLK3/PSA in prostate cancer cells. [Mol Cell Biol] Abstract

The RNA-Binding Protein HuR Opposes the Repression of ERBB-2 Expression by miR-331-3p in Prostate Cancer Cells
Here researchers investigate a U rich element situated in close proximity to the distal miR-331-3p target site in the ERBB-2 3-UTR. [J Biol Chem] Abstract

Prioritizing Candidate Disease miRNAs by Topological Features in the miRNA Target–Dysregulated Network: Case Study of Prostate Cancer
According to the assumption that miRNAs implicated in a specific tumor phenotype will show aberrant regulation of their target genes, researchers introduce an approach based on the miRNA target–dysregulated network to prioritize novel disease miRNAs. [Mol Cancer Ther] Abstract

A DNA Methylation Microarray-Based Study Identifies ERG as a Gene Commonly Methylated in Prostate Cancer
Because prior reports demonstrating that DNA methylation is important in prostate cancer studied a limited number of genes, researchers systematically quantified the DNA methylation status of 1505 CpG dinucleotides for 807 genes in 78 paraffin-embedded prostate cancer samples and three normal prostate samples. [Epigenetics] Abstract

Lenalidomide Enhances the Anti-Prostate Cancer Activity of Docetaxel In Vitro and In Vivo
In this study, researchers investigated the effects of combining lenalidomide and docetaxel on in vitro and in vivo models of prostate cancer as a potential strategy for treatment of castrate resistant prostate cancer. [Prostate] Abstract

Immunohistochemical Staining of Slit2 in Primary and Metastatic Prostatic Adenocarcinoma
Here researchers use immunohistochemistry to evaluate the expression of Slit2 in normal donor prostate, benign prostatic hyperplasia, high-grade prostatic intraepithelial neoplasia, normal tissue adjacent to prostatic adenocarcinoma, primary prostatic adenocarcinoma, and metastatic prostatic adenocarcinoma. [Transl Oncol] Abstract

CLINICAL RESEARCH

Palliation and Survival After Repeated ¹⁸⁸Re-HEDP Therapy of Hormone-Refractory Bone Metastases of Prostate Cancer: A Retrospective Analysis
This retrospective study compared the effects of single and multiple administrations of ¹⁸⁶Re-hydroxyethylidenediphosphonate (¹⁸⁶Re-HEDP) on palliation and survival of prostate cancer patients presenting with more than 5 skeletal metastases. [J Nucl Med] Abstract

Detection and Verification of Glycosylation Patterns of Glycoproteins from Clinical Specimens Using Lectin Microarrays and Lectin-based Immunosorbent Assays
The observed differences in glycosylation patterns of PSA and membrane metallo-endopeptidase may represent significant clinical importance, and could used to develop multiplex assays for diagnosis of aggressive prostate cancer. [Anal Chem] Abstract

Copy Number Alterations in Prostate Tumors and Disease Aggressiveness
Researchers undertook a genome-wide copy number alterations study of clinicopathological characteristics of 62 prostate tumors using the Illumina 1M single nucleotide polymorphism array. [Genes Chromosomes Cancer] Abstract

A Phase II Study of Insulin-Like Growth Factor Receptor Inhibition with Nordihydroguaiaretic Acid in Men with Non-Metastatic Hormone-Sensitive Prostate Cancer
In this study the efficacy of nordihydroguaiaretic acid, a small molecule inhibitor of the IGF-1R, was prospectively evaluated in patients with non-metastatic hormone-sensitive prostate cancer. [Oncol Rep] Abstract

Fox Chase Researchers Find that More Aggressive Treatment is Not Necessary for Men with A Family History of Prostate Cancer
Researchers report that men with a family history of prostate cancer should expect equally good outcomes following radiotherapy for prostate cancer as patients without a family history. [Press release from the Fox Chase Cancer Center discussing research presented at the 53rd Annual Meeting of the American Association for Radiation Oncology] Press Release

Fox Chase Researchers Develop a New Tool That Helps Identify Prostate Cancer Patients with the Highest Risk of Death
Fox Chase Cancer Center researchers have found that the time between the last radiation treatment and biochemical failure can accurately predict a patient’s risk of death of prostate cancer. [Press release from the Fox Chase Cancer Center discussing research presented at the 53rd Annual Meeting of the American Association for Radiation Oncology] Press Release

Fox Chase Researchers Improve Accuracy of IMRT Delivery in Post-Prostatectomy Patients
A new study has revealed that a portion of the prostate bed is located outside the Intensity Modulated Radiation Therapy (IMRT) treatment margins in a significant percentage of post-prostatectomy patients, suggesting that they may be receiving too little treatment in the appropriate area and too much in surrounding structures during the course of their treatment. [Press release from the Fox Chase Cancer Center discussing research presented at the 53rd Annual Meeting of the American Association for Radiation Oncology] Press Release

Studies Examine Diet’s Role in Prostate Cancer
A team of nutrition researchers and urologic surgeons at Washington University School of Medicine in St. Louis and the Siteman Cancer Center is conducting two studies to investigate a potential link between cancer and excess protein in the diet. [Washington University School of Medicine, St. Louis] Press Release

Io Therapeutics, Inc. Announces Initiation of Dosing in a Phase II Clinical Trial of IRX4204 in Patients With Advanced Prostate Cancer
Io Therapeutics, Inc. announced initiation of dosing in a phase II clinical trial with its experimental cancer therapeutic, IRX4204, in patients with advanced prostate cancer. [MarketWatch] Press Release

NCI Renews UAB Comprehensive Cancer Center’s $27.5 Million Core Grant
The University of Alabama at Birmingham (UAB) Comprehensive Cancer Center has received a five-year, $27.5 million Cancer Center Support Grant from the National Cancer Institute (NCI) to renew support for its cancer research program through 2016. [University of Alabama] Press Release

Stem Cell Centre Gets Green Light from UK Government
The prime minister will this month announce the creation of a £30m centre to turn scientists’ stem cell research into a new multimillion-pound industry to help drive Britain’s recovery. [The Guardian] Press Release

Maryland Stem Cell Research Commission Issues 2012 Requests for Applications (RFAs) at Fourth Annual Stem Cell Symposium
The symposium provided an opportunity for the public to learn about Maryland’s stem cell research program and FY 2012 RFAs. [Maryland Stem Cell Research Fund] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Postdoctoral Fellow – Cancer Genome Project (Wellcome Trust Sanger Institute)

Research Associate – Development (Precision Therapeutics, Inc.) 

Postdoctoral Fellow in Prostate Cancer Research (University of Texas Southwestern Medical Center)

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