| PUBLICATIONS (Ranked by Impact Factor of the Journal) | LABORATORY RESEARCH New Gene-Immunotherapy Combining TRAIL-Lymphocytes and EpCAMxCD3 Bispecific Antibody for Tumor Targeting Here, lymphocytes were transduced with TRAIL lentivirus and the anti-tumor effect in presence and absence of EpCAMxCD3 was evaluated in vitro and in xenograft studies using EpCAM-positive pancreatic and prostate cancer cells. [Clin Cancer Res] Abstract Regulation of Monocyte Chemoattractant Protein-1 through Angiotensin II Type 1 Receptor in Prostate Cancer In this study, researchers investigated the clinical outcome of monocyte chemoattractant protein-1 (MCP-1) expression in patients with prostate cancer (CaP) and the regulation of MCP-1 through angiotensin II type 1 receptor in CaP. [Am J Pathol] Abstract Differential Targeting of Androgen and Glucocorticoid Receptors Induces Endoplasmic Reticulum Stress and Apoptosis in Prostate Cancer Cells: A Novel Therapeutic Modality Researchers’ data validate the concept of dual androgen/glucocorticoid targeting in prostate cancer (PC) and suggest that Bortezomib combination with dual-target steroid receptor modulator compound A has high potential for PC therapy. [Cell Cycle] Abstract Systemic Blockade of the Hyaluronan Receptor for Endocytosis (HARE) Prevents Lymph Node Metastasis of Prostate Cancer In this study, researchers tested the hypothesis that HARE can act as an endothelial receptor for metastatic tumor cells with pericellular hyaluronan. [Int J Cancer] Abstract Hedgehog Signaling in Myofibroblasts Directly Promotes Prostate Tumor Cell Growth Researchers developed an in vitro co-culture model using microchannel technology to examine the effect of paracrine Hedgehog signaling on proliferation of prostate cancer cells. [Integr Biol] Abstract MicroRNA-34a Modulates c-Myc Transcriptional Complexes to Suppress Malignancy in Human Prostate Cancer Cells Researchers studied the functional effects of microRNA-34a (miR-34a) on c-Myc transcriptional complexes in PC-3 prostate cancer cells. [PLoS One] Abstract Altered CXCR3 Isoform Expression Regulates Prostate Cancer Cell Migration and Invasion Here, researchers examined the expression and function of two CXCR3 variants in human prostate cancer biopsies and cell lines. [Mol Cancer] Abstract Increased TGF-ß1-Mediated Suppression of Growth and Motility in Castrate-Resistant Prostate Cancer Cells Is Consistent with Smad2/3 Signaling This study analyzed prostate cancer responses to TGF-ß signaling in an isogenic model of androgen-sensitive and castration-resistant prostate cancer cells. [Prostate] Abstract Activation of Nod1 and Nod2 Induces Innate Immune Responses of Prostate Epithelial Cells In this study, researchers determined whether Nod1 and Nod2 are involved in the innate immune responses of prostate epithelial cells. [Prostate] Abstract CLINICAL RESEARCH Germline Mutations in HOXB13 and Prostate-Cancer Risk Researchers found the novel HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer. [N Engl J Med] Abstract | Press Release Bone Scan Index: A Quantitative Treatment Response Biomarker for Castration-Resistant Metastatic Prostate Cancer This study tested whether treatment-related changes in bone scan index (BSI) are prognostic for survival and compared BSI to prostate-specific antigen as an outcome measure. [J Clin Oncol] Abstract Prostate Cancer Screening in the Randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial: Mortality Results after 13 Years of Follow-up The prostate component of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial was undertaken to determine whether there is a reduction in prostate cancer mortality from screening using serum prostate-specific antigen testing and digital rectal examination. Here, researchers report extended follow-up to 13 years after the trial. [J Natl Cancer Inst] Abstract | Press Release The Value of Urinary Prostate Cancer Gene 3 (PCA3) Scores in Predicting Pathological Features at Radical Prostatectomy The objective of this study was to assess correlations between PCA3 levels and pathological features of radical prostatectomy specimens, which define cancer aggressiveness. [BJU Int] Abstract |
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