Prostate Cell News Volume 3.02 | Jan 20 2012

LABORATORY RESEARCH

Antagonists of Growth Hormone-Releasing Hormone Inhibit Growth of Androgen-Independent Prostate Cancer through Inactivation of ERK and Akt Kinases
Researchers evaluated the effects of the growth hormone-releasing hormone antagonist, JMR-132, on PC-3 human androgen-independent prostate cancer cells in vitro and in vivo. [Proc Natl Acad Sci USA] Abstract

Oncogene-Specific Activation of Tyrosine Kinase Networks during Prostate Cancer Progression
Researchers generated a mouse model of prostate cancer progression using commonly perturbed non-tyrosine kinase oncogenes and pathways and detected a significant up-regulation of tyrosine phosphorylation at the carcinoma stage. [Proc Natl Acad Sci USA] Abstract

SIRT1 Induces EMT by Cooperating with EMT Transcription Factors and Enhances Prostate Cancer Cell Migration and Metastasis
Here, researchers propose a novel mechanism through which the nicotinamide adenine dinucleotide-dependent histone deacetylase SIRT1 regulates epithelial-to-mesenchymal transition (EMT) in prostate cancer cells through cooperation with the EMT inducing transcription factor ZEB1. [Oncogene] Abstract

Disseminated Prostate Cancer Cells Can Instruct Hematopoietic Stem and Progenitor Cells to Regulate Bone Phenotype
Researchers examined if metastatic prostate cancer cells can alter regulation of normal bone formation by hematopoietic stem cells and hematopoietic progenitor cells. [Mol Cancer Res] Abstract

Inhibition of Migration and Invasion of LNCaP Human Prostate Carcinoma Cells by Cordycepin through Inactivation of Akt
In this study, the relationship between inhibition of cell motility and anti-invasive activity by cordycepin in LNCaP human prostate carcinoma cells was investigated. [Int J Oncol] Abstract

Tumorspheres Derived from Prostate Cancer Cells Possess Chemoresistant and Cancer Stem Cell Properties
In this study, researchers aimed to investigate the potential role of cancer stem cells in prostate cancer progression. [J Cancer Res Clin Oncol] Abstract

Adiponectin Inhibits Oxidative Stress in Human Prostate Carcinoma Cells
Human 22Rv1 and DU-145 prostate cancer cell lines were examined for the generation of oxidative stress and detoxification of reactive oxygen species after treatment with adiponectin. [Prostate Cancer Prostatic Dis] Abstract

CLINICAL RESEARCH

Changes in Circulating MicroRNA Levels Associated with Prostate Cancer
The aim of this study was to investigate the hypothesis that changes in circulating microRNAs represent potentially useful biomarkers for the diagnosis, staging and prediction of outcome in prostate cancer. [Br J Cancer] Abstract

High-Dose Radiotherapy with or without Androgen Deprivation Therapy for Intermediate-Risk Prostate Cancer: Cancer Control and Toxicity Outcomes
The purpose of this study was to evaluate the impact of short-course androgen deprivation therapy on cancer control outcomes and toxicity in intermediate-risk prostate cancer treated with dose-escalated external beam radiotherapy (high-dose radiotherapy). [Int J Radiat Oncol Biol Phys] Abstract

BCAR1 Expression Improves Prediction of Biochemical Recurrence after Radical Prostatectomy
Since steroid hormones play a central role in the development and progression of prostate cancer, researchers aimed to analyze in a matched nested case-control study the value of molecules involved in steroid signaling, to predict recurrence after radical prostatectomy, independently from standard prognostic tools. [Prostate] Abstract

Prostatic Cancer Surveillance following Whole-Gland High-Intensity Focused Ultrasound: Comparison of MRI and Prostate-Specific Antigen for Detection of Residual or Recurrent Disease
This retrospective study compares dynamic contrast-enhanced MRI with the serial prostate-specific antigen measurement for detection of residual disease following whole-gland high-intensity-focused ultrasound therapy of prostate cancer. [Br J Radiol] Abstract

CIRM Allocates $40 Million to Support Stem Cell Genomics, Speeding Development of Therapies for Patients
California stem cell scientists will have a new resource for advancing therapies with a $40 million initiative approved by the governing board of the California Institute for Regenerative Medicine (CIRM). [California Institute For Regenerative Medicine] Press Release

Damon Runyon Grants Fellowship and Breakthrough Scientist Awards to 21 Top Young Scientists
The Damon Runyon Cancer Research Foundation named 18 new Damon Runyon Fellows at its fall Fellowship Award Committee review. [Damon Runyon Cancer Research Foundation] Press Release

Research and Development Technologist, hPSC Media (STEMCELL Technologies) 

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientific Marketing Communications Specialist (STEMCELL Technologies Inc.)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Research Associate – Development (Precision Therapeutics, Inc.)

Postdoctoral Research Fellow – Epidemiology / Prostate Studies (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow (Baylor College of Medicine)

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