LABORATORY RESEARCH LaminA/C Protein Is Overexpressed in Tissue-Invading Prostate Cancer and Promotes Prostate Cancer Cell Growth, Migration and Invasion through the Phosphoinositide 3-Kinase/AKT/PTEN Pathway To characterize laminA/C’s function in prostate cancer cells, researchers performed a detailed expression analysis in prostate cancer tissue and explored the consequences of down or up-regulation of laminA/C in prostate cancer cells. [Carcinogenesis] Abstract Preclinical Characterization of a Novel Diphenyl Benzamide Selective ERα Agonist for Hormone Therapy in Prostate Cancer Scientists describe a novel nonsteroidal selective estrogen receptor-α agonist designed for first-line therapy of advanced prostate cancer that in animal models induces medical castration and minimizes many of the estrogen deficiency-related side effects of androgen deprivation therapy. [Endocrinology] Abstract Casein Kinase 2 Inhibition Attenuates Androgen Receptor Function and Cell Proliferation in Prostate Cancer Cells In this study, researchers tested the effects of tetra-bromo-cinnamic acid, a newly synthetic casein kinase 2 (CK2)-selective CK2 inhibitor, on androgen receptor transactivation, cell proliferation, and viability in multiple prostate cancer cell lines. [Prostate] Abstract Autophagy Regulates Lipolysis and Cell Survival through Lipid Droplet Degradation in Androgen-Sensitive Prostate Cancer Cells The objective of this study was to elucidate the function of autophagy in lipid droplet homeostasis and survival in androgen-sensitive prostate cancer cells. [Prostate] Abstract Glycoprotein Transmembrane nmb: An Androgen-Downregulated Gene Attenuates Cell invasion and Tumorigenesis in Prostate Carcinoma Cells Scientists suggest that the glycoprotein transmembrane nmb gene is a p53- and androgen-dysregulated gene and should be regarded as an anti-tumor gene for prostate cancer. [Prostate] Abstract ProstaCaid™ Inhibits Tumor Growth in a Xenograft Model of Human Prostate Cancer In the present study, researchers evaluated toxicity and whether ProstaCaid™ suppresses growth of prostate cancer in a xenograft model of human prostate cancer cells implanted in mice. [Int J Oncol] Abstract The Anti-Obesity Drug Orlistat Promotes Sensitivity to TRAIL by Two Different Pathways in Hormone-Refractory Prostate Cancer Cells Investigators report that the anti-obesity drug orlistat enhances the sensitivity to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in hormone-refractory prostate cancer cells through two different pathways. [Int J Oncol] Abstract CLINICAL RESEARCH High-Dose-Rate Brachytherapy and External-Beam Radiotherapy for Hormone-Naïve Low- and Intermediate-Risk Prostate Cancer: A 7-Year Experience The purpose of this study was to report clinical outcomes and early and late complications in 264 hormone-naïve patients with low- and intermediate-risk prostate cancer treated with high-dose-rate brachytherapy in combination with external-beam radiotherapy. [Int J Radiat Oncol Biol Phys] Abstract A Panel of Five Circulating MicroRNAs as Potential Biomarkers for Prostate Cancer In this study, researchers investigated whether circulating microRNAs could be used in the diagnosis of prostate cancer in a Chinese patient population. [Prostate] Abstract Effect of Treatment with 5-α Reductase Inhibitors on Progression in Monitored Men with Favorable-Risk Prostate Cancer The objective of this study was to determine whether 5-α reductase inhibitor use delays cancer reclassification in an active surveillance cohort. [BJU Int] Abstract |