LABORATORY RESEARCH DNA Methylation Silences MiR-132 in Prostate Cancer To screen for epigenetically silenced microRNAs (miRNAs) in prostate cancer, researchers treated prostate normal epithelial and carcinoma cells with 5-aza-2′-deoxycytidine and subsequently examined expression changes of 650 miRNAs by megaplex stemloop reverse transcription-quantitative PCR. [Oncogene] Abstract Remarkable Inhibition of mTOR Signaling by the Combination of Rapamycin and 1,4-Phenylenebis(Methylene)Selenocyanate in Human Prostate Cancer Cells Based on the synthetic organoselenium compound p-XSC’s inhibition of Akt, researchers hypothesized that p-XSC modulates mammalian target of rapamycin (mTOR) C2, an upstream regulator of the kinase. They then further hypothesized that combining p-XSC with rapamycin, an mTORC1 inhibitor, would be an effective combinatory strategy for the inhibition of prostate cancer. [Int J Cancer] Abstract Androgen-Regulated Transcriptional Control of Sialyltransferases in Prostate Cancer Cells Investigators demonstrate that GD1a was produced in abundance in cancerous tissue samples from human patients with hormone-sensitive prostate cancers as well as castration-resistant prostate cancers. [PLoS One] Abstract Caffeic Acid Phenethyl Ester Causes p21Cip1 Induction, Akt Signaling Reduction, and Growth Inhibition in PC-3 Human Prostate Cancer Cells Researchers find caffeic acid phenethyl ester treatment suppressed proliferation, colony formation, and cell cycle progression in PC-3 human prostate cancer cells. [PLoS One] Abstract MiR-141 Modulates Androgen Receptor Transcriptional Activity in Human Prostate Cancer Cells through Targeting the Small Heterodimer Partner Protein Researchers investigated the correlation of small heterodimer partner expression with the cellular level of microR-141 (miR-141) and its effects on androgen receptor transcriptional activity in non-malignant and malignant human prostate epithelial cell lines. [Prostate] Abstract Regulation of Cell Proliferation through a KIT-Mediated Mechanism in Benign Prostatic Hyperplasia Scientists investigated the role of the KIT-mediated mechanism in benign prostatic hyperplasia (BPH), and discuss the pathophysiology of BPH and a candidate target of BPH medical therapy. [Prostate] Abstract Reprogramming of Prostate Cancer-Associated Stromal Cells to Embryonic Stem-Like In this study CD90+ prostate cancer-associated stromal cells, isolated from tumor tissue of a surgically resected prostate by anti-CD90-mediated sorting and cultured in vitro, were transfected with in vitro packaged lentiviral expression vectors containing stem cell transcription factor genes POU5F1, LIN28, NANOG, and SOX2. [Prostate] Abstract CLINICAL RESEARCH Circulating Sphingosine-1-Phosphate and Erythrocyte Sphingosine Kinase-1 Activity as Novel Biomarkers for Early Prostate Cancer Detection This study has provided a potential mechanism for cancer-related anemia and the first evidence that plasma sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity are the potential markers for the diagnosis, monitoring, and predicating for prostate cancer mortality. [Br J Cancer] Abstract Milk and Dairy Consumption among Men with Prostate Cancer and Risk of Metastases and Prostate Cancer Death Scientists investigated post-diagnostic milk and dairy intake in relation to risk of lethal prostate cancer (metastases and prostate cancer death) among participants in the Health Professionals Follow-Up Study. [Cancer Epidemiol Biomarkers Prev] Abstract Androgen Deprivation Therapy for Prostate Cancer Does Not Increase Cardiovascular Mortality in the Long Term Researchers determine if six months of neo-adjuvant androgen deprivation is associated with the long-term risk of cardiac mortality. [Oncology] Abstract |