LABORATORY RESEARCH IRX4 at 5p15 Suppresses Prostate Cancer Growth through the Interaction with Vitamin D Receptor, Conferring Prostate Cancer Susceptibility In this study, researchers found knockdown of IRX4 prostate cancer (PC) cells enhanced their growth and IRX4 overexpression in PC cells suppressed their growth, indicating the functional association of IRX4 with PC and its tumor suppressive effect. [Hum Mol Genet] Abstract The SRA Protein UHRF1 Promotes Epigenetic Crosstalks and Is Involved in Prostate Cancer Progression Here, scientists report that UHRF1 is frequently over expressed in human prostate tumors and has an important role in prostate cancer pathogenesis and progression. [Oncogene] Abstract Androgen Receptor Exon 1 Mutation Causes Androgen Insensitivity by Creating a Phosphorylation Site and Inhibiting Melanoma Antigen-A11 Activation of N/C Interaction-Dependent Transactivation In this report researchers investigate the functional defect associated with an androgen receptor exon 1 missense mutation R405S that caused partial androgen insensitivity. [J Biol Chem] Abstract Acid Ceramidase-Mediated Production of Sphingosine 1-Phosphate Promotes Prostate Cancer Invasion through Up-Regulation of Cathepsin B Here investigators demonstrate that acid ceramidase, through generation of sphingosine-1-phosphate, promotes Ets1 nuclear expression and binding to the promoter region of matrix-degrading protease cathepsin B. [Int J Cancer] Abstract Cell-to-Cell Signaling Influences the Fate of Prostate Cancer Stem Cells and Their Potential to Generate More Aggressive Tumors To address whether tumor aggressiveness is driven by cancer stem cells (CSC) and by what extent this property may be relevant within the tumor mass, scientists isolated a rare tumor cell population on the basis of its CD44+CD24– phenotype from the human androgen-independent prostate carcinoma cell line DU145 and established its CSC properties. [PLoS One] Abstract CXCR4 Expression in Prostate Cancer Progenitor Cells Researchers show that the CXCR4/CXCL12 axis, a key regulator of tumor dissemination, plays a role in the maintenance of prostate cancer stem-like cells. [PLoS One] Abstract Androgen-Induced Cell Migration: Role of Androgen Receptor/Filamin A Association Researchers’ data indicates that the extra nuclear androgen receptor/filamin A/integrin beta 1 complex is the key by which androgen activates signaling leading to cell migration. [PLoS One] Abstract CLINICAL RESEARCH Combined Immunotherapy with Granulocyte-Macrophage Colony-Stimulating Factor-Transduced Allogeneic Prostate Cancer Cells and Ipilimumab in Patients with Metastatic Castration-Resistant Prostate Cancer: A Phase I Dose-Escalation Trial Researchers aimed to assess the safety of combined treatment with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells vaccine and ipilimumab in patients with metastatic castration-resistant prostate cancer. [Lancet Oncol] Abstract Ipilimumab and a Poxviral Vaccine Targeting Prostate-Specific Antigen in Metastatic Castration-Resistant Prostate Cancer: A Phase I Dose-Escalation Trial Scientists aimed to assess the safety and tolerability of ipilimumab in combination with a poxviral-based vaccine targeting prostate-specific antigen and containing transgenes for T-cell co-stimulatory molecule expression, including CD80. [Lancet Oncol] Abstract Does Local Recurrence of Prostate Cancer after Radiation Therapy Occur at the Site of Primary Tumor? Results of a Longitudinal MRI and MRSI Study The purpose of this study was to determine if local recurrence of prostate cancer after radiation therapy occurs at the same site as the primary tumor before treatment, using longitudinal magnetic resonance (MR) imaging and MR spectroscopic imaging to assess dominant tumor location. [Int J Radiat Oncol Biol Phys] Abstract |