Prostate Cell News Volume 3.17 | May 11 2012

miR-205 Regulates Basement Membrane Deposition in Human Prostate: Implications for Cancer Development
Scientists demonstrated that therapeutic replacement of microRNA-205 (miR-205) in prostate cancer cells can restore basement membrane deposition and three-dimensional organization into normal-like acinar structures, thus hampering cancer progression. [Cell Death Differ] Abstract

LABORATORY RESEARCH

miRNA-708 Control of CD44+ Prostate Cancer Initiating Cells
Investigators report that miR-708 is a key negative regulator of a CD44+ subpopulation of prostate cancer cells, with important implications for diagnosis and prognosis of this disease. [Cancer Res] Abstract

Regional Cell Proliferation in Microdissected Human Prostate Specimens after Heavy Water-Labeling In Vivo: Correlation with Prostate Epithelial Cells Isolated from Seminal Fluid
Researchers described two novel in vivo metrics of cell proliferation in men with prostate neoplasia. [Clin Cancer Res] Abstract

Targeting Fibroblast Growth Factor Receptor Signaling Inhibits Prostate Cancer Progression
Investigators determined whether targeting fibroblast growth factor receptor (FGFR) signaling from all four FGFRs would have in vitro activities consistent with inhibition of tumor progression and would inhibit tumor progression in vivo. [Clin Cancer Res] Abstract

Ack1 Mediated Androgen Receptor Phosphorylation Modulates Radiation Resistance in Castration
Resistant Prostate Cancer
Scientists demonstrated that phosphorylated tyrosine-267-androgen receptor is recruited to the ataxia telangiectasia mutated (ATM) enhancer in Ack1 dependent manner to upregulate ATM expression. [J Biol Chem] Full Article

Effect of a Low-Fat Diet Combined with IGF-1 Receptor Blockade on 22Rv1 Prostate Cancer Xenografts
Investigators hypothesized that a low-fat diet combined with IGF-I receptor (IGF-1R) blockade would cause additive inhibition of prostate cancer growth and offset possible untoward metabolic effects of IGF-1R blockade antibody therapy. [Mol Cancer Ther] Abstract

Caffeic Acid Phenethyl Ester Suppresses the Proliferation of Human Prostate Cancer Cells through Inhibition of p70S6K and Akt Signaling Networks
Investigators took a systematic approach to uncover the effects of caffeic acid phenethyl ester from hours to days on the signaling networks in human prostate cancer cells. [Cancer Prev Res]
Abstract | Press Release

Osteoblast-Secreted Collagen Upregulates Paracrine Sonic Hedgehog Signaling by Prostate Cancer Cells and Enhances Osteoblast Differentiation
Researchers investigated the formation of a collagen matrix by osteoblasts cultured with prostate cancer cells, and its effects on interactions between prostate cancer cells and osteoblasts. [Mol Cancer] Full Article

Anti-Inflammatory Effect of Androgen Receptor Activation in Human BPH Cells
Scientists investigated whether hypogonadism was associated with more severe benign prostatic hyperplasia (BPH) inflammation and the in vitro effect of the selective androgen receptor agonist dihydrotestosterone on cultures of stromal cells derived from BPH patients. [J Endocrinol] Abstract

Increased Expression of Basic Helix Loop Helix Transcription Factor E2A (TCF3) in Prostate Cancer Promotes Proliferation and Confers Resistance to Doxorubicin Induced Apoptosis
Researchers demonstrated for the first time that TCF3 could in fact acts as a tumor promoter in prostate cancer. [Biochem Biophys Res Commun] Abstract

CLINICAL RESEARCH

Conformal Postoperative Radiotherapy in Patients with Positive Resection Margins and/or pT3-4 Prostate Adenocarcinoma
Scientists aimed to evaluate outcome and toxicity of high-dose conformal radiotherapy after radical prostatectomy. [Int J Radiat Oncol Biol Phys] Abstract

Multiparametric Magnetic Resonance Imaging of the Prostate Can Improve the Predictive Value of the Urinary Prostate Cancer Antigen 3 Test in Patients with Elevated Prostate-Specific Antigen Levels and a Previous Negative Biopsy
Researchers aimed to evaluate the role of multiparametric magnetic resonance imaging as an additional diagnostic tool for improving the accuracy of the urinary prostate cancer antigen 3 test in patients with an increase in prostate-specific antigen levels and a previous negative prostate biopsy. [BJU Int] Abstract

Exelixis Expands the Cabozantinib Development Program through NCI-CTEP Collaboration
Exelixis, Inc. announced a broad expansion of the cabozantinib development program under a Cooperative Research and Development Agreement with the National Cancer Institute’s Cancer Therapy Evaluation Program (NCI-CTEP), with the approval of the initial program of 12 proposed clinical trials under the agreement. [Exelixis, Inc.] Press Release

Genomic Health and OncoMed Announce Strategic Alliance for Biomarker Research and Discovery Using Next Generation Sequencing
Genomic Health, Inc. and OncoMed Pharmaceuticals, Inc. announced a strategic alliance to use next generation sequencing to identify biomarkers that can be applied to the clinical development of OncoMed’s novel antibody cancer therapeutics. [Genomic Health, Inc.] Press Release

OPKO Health Enters into License Agreement with International Health Technology for Next Generation Prostate Cancer Biomarker Panel
OPKO Health, Inc. announced execution of a license agreement granting International Health Technology, Ltd. the right to offer OPKO’s novel panel of kallikrein biomarkers and associated algorithm for the detection of prostate cancer in a laboratory setting. [OPKO Health, Inc.] Press Release

ProUroCare Medical Receives FDA Clearance for ProUroScan Elasticity Imaging System
ProUroCare Medical Inc. announced it has received clearance from the U.S.Food & Drug Administration (FDA) for its ProUroScan™ prostate mechanical imaging system. [ProUroCare Medical Inc.] Press Release

UM’s Interdisciplinary Stem Cell Institute Awarded $10 Million Grant from Starr Foundation
The grant will support the University of Miami (UM) Miller School of Medicine’s Interdisciplinary Stem Cell Institute in broadening its preclinical and clinical research on stem cells, and help accelerate its pipeline of translational research and programs for a wide range of debilitating conditions. [University of Miami Miller School of Medicine] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW European Molecular Biology Laboratory Conference: Stem Cells in Cancer and Regenerative Medicine
August 29-September 1, 2012
Heidelberg, Germany 
 
Visit our events page to see a complete list of events in the prostate cell community.

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Clinical Research Associate (Jennerex Biotherapeutics, Inc.)

Research Associate – Development (Precision Therapeutics, Inc.)

Postdoctoral Fellow – Prostate Cancer (University of Colorado)

Postdoctoral Fellow/Associate Research Scientist – Prostate Cancer (Columbia University Medical Center)

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