LABORATORY RESEARCH Expression of Inhibitor of DNA-Binding Proteins Is Regulated by the Bcl-3 Proto-Oncogene in Prostate Cancer Researchers suggested that inactivation of B-cell leukemia 3 (Bcl-3) may lead to sensitization of cancer cells to chemotherapeutic drug-induced apoptosis, thus implying a potential therapeutic strategy in prostate cancer treatment. [Oncogene] Abstract Evidence for Efficacy of New HSP 90 Inhibitors Revealed by Ex Vivo Culture of Human Prostate Tumors Investigators evaluated the biological actions of two new synthetic heat shock protein 90 (Hsp90) inhibitors in prostate cancer cell lines and in an ex vivo culture model of human prostate cancer. [Clin Cancer Res] Abstract Differential Regulation of Androgen Receptor by PIM-1 Kinases via Phosphorylation-Dependent Recruitment of Distinct Ubiquitin E3 Ligases Scientists reported that two PIM-1 kinase isoforms which are upregulated during prostate cancer progression, modulate androgen receptor stability and transcriptional activity. [J Biol Chem ] Full Article A Competitive Inhibitor that Reduces Recruitment of Androgen Receptor to Androgen Responsive Genes To identify novel inhibitors of androgen receptor (AR) transactivation that block growth of prostate cancer cells, a luciferase-based high throughput screen of approximately 160,000 small molecules was performed in cells stably expressing AR and a prostate-specific antigen-luciferase reporter. [J Biol Chem] Full Article Telomere and Microtubule Targeting in Treatment-Sensitive and Treatment-Resistant Human Prostate Cancer Cells Scientists evaluated the relative efficacy of targeting telomeres and microtubules in taxane-sensitive, taxane-resistant, androgen-sensitive and androgen-insensitive prostate cancer cells. [Mol Pharmacol] Full Article Constitutive and Treatment-Induced CXCL8-Signaling Selectively Modulates the Efficacy of Anti-Metabolite Therapeutics in Metastatic Prostate Cancer Investigators characterized the effect of anti-metabolites on inducing CXCL8 signaling and determined whether the constitutive and/or drug-induced CXCL8 signaling in metastatic prostate cancer cells modulates their sensitivity to this class of agent. [PLoS One] Full Article Piperlongumine Induces Rapid Depletion of the Androgen Receptor in Human Prostate Cancer Cells Researchers investigated the functional impact of piperlongumine on androgen receptor expression in prostate cancer cells. [Prostate] Abstract Uptake and Antitumoral Effects of Iodine and 6-Iodolactone in Differentiated and Undifferentiated Human Prostate Cancer Cell Lines Investigators determined the uptake of iodide and iodine, as well as the antiproliferative and apoptotic effects of 6-iodolactone and both forms of iodine in human prostate cells lines. [Prostate] Abstract Targeted Therapy with Fatty Acid Synthase Inhibitors in a Human Prostate Carcinoma LNCaP/Tk-Luc-Bearing Animal Model Researchers used C75 and small interfering RNA targeted at fatty acid synthase to mediate the endogenous fatty acid metabolism in LNCaP human prostate cancer cells stably expressing herpes simplex virus type 1 thymidine kinase (HSV1-tk) and luciferase (luc) reporter genes. [Prostate Cancer Prostatic Dis] Abstract CLINICAL RESEARCH Prospective Study of Changes in the Metabolomic Profiles of Men during Their First Three Months of Androgen Deprivation Therapy for Prostate Cancer To better characterize the metabolic effects of androgen deprivation therapy, researchers measured changes in plasma metabolomic profile at baseline and after the first three months of therapy. [Clin Cancer Res] Abstract Outcome Predictors of Radical Prostatectomy followed by Adjuvant Androgen Deprivation in Patients with Clinical High Risk Prostate Cancer and pT3 Surgical Margin Positive Disease Researchers performed subset analysis of a prospective trial including 550 consecutive patients with preoperative high risk prostate cancer. [J Urology] Abstract |