Prostate Cell News Volume 3.25 | Jul 6 2012

Aurora B Is Regulated by Acetylation/Deacetylation During Mitosis in Prostate Cancer Cells
Using IP with an anti-acetyl lysine antibody, scientists identified Aurora B as an acetylated protein in PC3 prostate cancer cells. [FASEB J] Abstract

LABORATORY RESEARCH

Induction of the Transcriptional Repressor ZBTB4 in Prostate Cancer Cells by Drug-Induced Targeting of MicroRNA-17-92/106b-25 Clusters
Researchers found that ZBTB4 levels are relatively low in DU145 and PC3 cells due to suppression by microRNA (miR) paralogs that are members of the miR-17-92 and miR-106b-25 clusters. [Mol Cancer Ther] Abstract

The Transcription Factor SPDEF Suppresses Prostate Tumor Metastasis
Scientists examined the effects of SAM pointed domain containing ETS transcription factor (SPDEF) on tumor cell metastasis using prostate tumor cells as a model. [J Biol Chem] Full Article

Slug, a Unique Androgen-Regulated Transcription Factor, Coordinates Androgen Receptor to Facilitate Castration Resistance in Prostate Cancer
Investigators identified Slug as a unique androgen-responsive gene in prostate cancer cells. [Mol Endocrinol] Abstract

The Importance of LDL and Cholesterol Metabolism for Prostate Epithelial Cell Growth
Researchers studied in vitro the effect of extracellular LDL-cholesterol on the number of prostate epithelial cells and on the expression of key regulators of cholesterol metabolism. [PLoS One] Full Article

Identification of Kinases Regulating Prostate Cancer Cell Growth Using an RNAi Phenotypic Screen
To identify signaling pathways that regulate prostate cancer cell growth, scientists screened a panel of shRNAs targeting 673 human kinases against LNCaP prostate cancer cells grown in the presence and absence of hormone. [PLoS One] Full Article

Magnetic Resonance Imaging of Prostate Cancer Antigen Expression for Diagnosis and lmmunotherapy
The immunotherapeutic efficacy of the monoclonal antibody 7F5@GoldMag in PC-3 tumor-bearing mice was verified with significant inhibition of tumor growth compared to untreated control animals. [PLoS One]
Full Article

Monascuspiloin Induces Apoptosis and Autophagic Cell Death in Human Prostate Cancer Cells via the Akt and AMPK Signaling Pathways
Researchers demonstrated that monascuspiloin has therapeutic potential for the treatment of both androgen-dependent and -independent human prostate cancers. [J Agric Food Chem] Abstract

Oridonin Up-Regulates Expression of P21 and Induces Autophagy and Apoptosis in Human Prostate Cancer Cells
Scientists demonstrated that after oridonin treatment, the proliferations of human prostate cancer cell lines PC-3 and LNCaP were inhibited in a concentration and time-dependent manner. [Int J Biol Sci] Abstract

Comparative Study of Rapamycin and Temsirolimus Demonstrates Superimposable Anti-Tumour Potency on Prostate Cancer Cells
Investigators carried out a comparative study on the effects of rapamycin and temsirolimus on the in vitro and in vivo growth of the prostate cancer cell lines, LnCap and PC3. [Basic Clin Pharmacol Toxicol] Abstract

CLINICAL RESEARCH

Indications for and Use of Nonsteroidal Antiinflammatory Drugs and the Risk of Incident, Symptomatic Benign Prostatic Hyperplasia: Results From the Prostate Cancer Prevention Trial
Researchers conducted a cohort study of nonsteroidal antiinflammatory drug use and risk of symptomatic benign prostatic hyperplasia. [Am J Epidemiol] Abstract

Treatment with Curative Intent and Survival in Men with High-Risk Prostate Cancer. A Population-Based Study of 11,380 Men with Serum PSA Level 20-100 ng/mL
Scientists investigated the influence of curative treatment on cause-specific mortality in men diagnosed with prostate cancer with serum prostate-specific antigen (PSA) levels between 20 and 100 ng/mL. [BJU Int] Abstract

Treatment Outcome of High-Dose Image-Guided Intensity-Modulated Radiotherapy Using Intraprostate Fiducial Markers for Localized Prostate Cancer at a Single Institute in Japan
Researchers evaluated the medium-term treatment outcome after high-dose, image-guided intensity-modulated radiotherapy using intra-prostate fiducial markers for clinically localized prostate cancer. [Radiat Oncol] Abstract | Full Article

Astellas Obtains Approval in Japan for Treating Prostate Cancer with Gonax® for Subcutaneous Injection
Astellas Pharma Inc. announced that Gonax® for Subcutaneous Injection was granted Japanese marketing approval for the indication of prostate cancer. [Astellas Pharma Inc.] Press Release

Dr. Kishor Wasan Receives Prostate Cancer Research Grant
Dr. Kishor Wasan, professor and associate dean of Research & Graduate Studies in the Faculty of Pharmaceutical Sciences at the University of British Columbia, is a recipient of a 2012 Prostate Cancer Canada Pilot Grant. [The University of British Columbia] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW The New York Stem Cell Foundation (NYSCF) Seventh Annual Translational Stem Cell Research Conference
October 10-11, 2012
New York City, United States

Visit our events page to see a complete list of events in the prostate cell community.

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Postdoctoral Position – Cancer Genomics (University of California)

Postdoctoral Position – Endocrinology of Prostate Cancer (Baylor College of Medicine)

Postdoctoral Position – Molecular Biology and Genomics (University Hospital Zurich)

Postdoctoral Position – Prostate Cancer Research (University of Texas Southwestern Medical Center)

Postdoctoral Position – Prostate Cancer (BC Cancer Agency)

Recruit Top Talent: Reach more than 50,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Prostate Cell News? Click here to submit!

Comments or Suggestions? Email info@connexoncreative.com with your feedback.