LABORATORY RESEARCH A Unique Galectin Signature in Human Prostate Cancer Progression Suggests Galectin-1 as a Key Target for Treatment of Advanced Disease Researchers undertook this study to analyze the ‘galectin signature’ of the human prostate cancer microenvironment with the overarching goal of selecting novel molecular targets for prognostic and therapeutic purposes. [Cancer Res] Abstract Increased PrLZ-Mediated Androgen Receptor Transactivation Promotes Castration Resistant Prostate Cancer Growth Scientists found PrLZ, a newly identified Prostate Leucine Zipper gene that is highly expressed in advanced prostate cancers could interact with the androgen receptor (AR) directly leading to enhance AR transactivation in the castration resistant condition. [Carcinogenesis] Abstract Myoblasts Inhibit Prostate Cancer Growth by Paracrine Secretion of TNF Alpha Researchers investigated the interactions between myoblasts and prostate carcinoma cells in vitro and in vivo. [J Urol] Abstract Transcript Levels of Androgen Receptor Variant AR-V1 or AR-V7 Do Not Predict Recurrence in Patients with Prostate Cancer at Indeterminate Risk for Progression Scientists investigated whether androgen receptor (AR)-V7 or V1 expression would predict biochemical recurrence in men at indeterminate risk for progression following radical prostatectomy. [J Urol] Abstract The Androgen Receptor: A Biologically Relevant Vaccine Target for the Treatment of Prostate Cancer Researchers evaluated the immune and anti-tumor efficacy of a DNA vaccine targeting the androgen receptor ligand-binding domain in relevant rodent preclinical models. [Cancer Immunol Immunother] Abstract Epigenetic Distortion to VDR Transcriptional Regulation in Prostate Cancer Cells Investigators aimed to examine the gene specific mechanisms by which the actions of the vitamin D receptor (VDR) are distorted in prostate cancer. [J Steroid Biochem Mol Biol] Abstract CLINICAL RESEARCH A Randomized, Double-Blind, Multicenter, Phase II Study of a Human Monoclonal Antibody to Human αν Integrins (Intetumumab) in Combination with Docetaxel and Prednisone for the First-Line Treatment of Patients with Metastatic Castration-Resistant Prostate Cancer In a phase II, randomized, double-blind, multicenter study, men with metastatic castration-resistant prostate cancer without prior systemic nonhormonal therapy were randomly assigned to 75-mg/m2 docetaxel (Taxotere) and 5-mg prednisone plus placebo or 10-mg/kg intetumumab three times weekly. [Ann Oncol] Abstract Prospective Study on Metabolic Factors and Risk of Prostate Cancer The authors found no evidence of an association between high levels of metabolic factors and the risk of prostate cancer, but high body mass index (BMI), elevated blood pressure, and a composite score of all metabolic factors were associated with an increased risk of death from prostate cancer. [Cancer] Abstract Dietary Folate and Folate Vitamers and the Risk of Prostate Cancer in The Netherlands Cohort Study Researchers aimed to examine the association between intake of folate, and specific folate vitamers, and the risk of advanced and total prostate cancer. [Cancer Causes Control] Abstract |