LABORATORY RESEARCH Cell-Based Selection Provides Novel Molecular Probes for Cancer Stem Cells Because few markers exist to identify and isolate pure cancer stem cells (CSC), researchers used cell-based systematic evolution of ligands by exponential enrichment to create DNA aptamers that can identify novel molecular targets on the surfaces of live CSC. Out of 22 putative DNA sequences, three bound to >90% and five bound to >15% of DU145 prostate cancer cells. [Int J Cancer] Abstract Reduction of Pro-Tumorigenic Activity of Human Prostate Cancer-Associated Fibroblasts Using Dlk1 or SCUBE1 Researchers set out to reduce the pro-tumorigenic activity of patient cancer-associated fibroblasts (CAFs) using the Dlk1 and SCUBE1 molecules that they had previously identified in prostate development. Their hypothesis was that mesenchymally expressed molecules might reduce CAF pro-tumorigenic activity, either directly or indirectly. [Dis Model Mech] Abstract | Press Release Anti-Proliferative Effects of Physiological Concentrations of Enterolactone in Models of Prostate Tumorigenesis Scientists investigated the anti-proliferative effects of enterolactone in an in vitro model of prostate tumorigenesis at concentrations reported to occur in a range of male populations. [Mol Nutr Food Res] Abstract Subcellular Localization of p44/WDR77 Determines Proliferation and Differentiation of Prostate Epithelial Cells Investigators found that p44 localizes in the cytoplasm of prostate epithelial cells at the early stage of prostate development when cells are proliferating, and its nuclear translocation is associated with cellular and functional differentiation in adult prostate tissue. [PLoS One] Full Article Human α2β1HI CD133+VE Epithelial Prostate Stem Cells Express Low Levels of Active Androgen Receptor Researchers re-examined the expression patterns of androgen receptor (AR) within adult prostate epithelial differentiation using an optimized sensitive and specific approach examining transcript, protein and AR regulated gene expression. [PLoS One] Full Article The Chicken Ovalbumin Upstream Promoter-Transcription Factor II Negatively Regulates the Transactivation of Androgen Receptor in Prostate Cancer Cells Scientists explored a putative role of chicken ovalbumin upstream promoter-transcription factor II (COUP-TF II) in prostate cancers by investigating its effect on cell proliferation and a cross-talk between COUP-TF II and androgen receptor. [PLoS One] Full Article Tumor-Associated Stromal Cells Expressing E-Prostanoid 2 or 3 Receptors in Prostate Cancer: Correlation with Tumor Aggressiveness and Outcome by Angiogenesis and Lymphangiogenesis To clarify the detailed pathologic roles of prostaglandin E2 in prostate cancer tissues, the authors investigated the clinical significance and prognostic roles of the density of tumor-associated stromal cells expressing specific receptors for prostaglandin E2, termed “E-prostanoid 1-4 receptors.” [Urology] Abstract CLINICAL RESEARCH Impact of the Introduction of a Robotic Training Programme on Prostate Cancer Stage Migration at a Single Tertiary Referral Centre 2511 consecutive patients treated with radical prostatectomy, with or without pelvic lymph node dissection, for prostate cancer (PCa) at a single tertiary care center were analyzed. Baseline patient characteristics and PCa risk distribution were compared according to treatment type (retropubic radical prostatectomy [RRP] vs robot-assisted radical prostatectomy [RARP]) in the overall population, as well as in three surgeons’ initial 50 RARP and three surgeons’ initial 50 RRP cases. [BJU Int] Abstract Second to Fourth Digit Ratio and Prostate Cancer Severity The authors investigated the ratio of the second to the fourth digit as a potential marker for prostate cancer severity. [Prostate Cancer Prostatic Dis] Abstract |