LABORATORY RESEARCH Stromal Epigenetic Dysregulation Is Sufficient to Initiate Mouse Prostate Cancer via Paracrine Wnt Signaling Researchers used high-mobility group AT-hook 2, an epigenetic regulator, to modify prostate stromal cells, and demonstrated that perturbation of the microenvironment by stromal-specific overexpression of this chromatin remodeling protein alone is sufficient to induce dramatic hyperplasia and multifocal prostatic intraepithelial neoplasia lesions from adjacent naïve epithelial cells. [Proc Natl Acad Sci USA] Abstract MicroRNA-320 Suppresses the Stem Cell-Like Characteristics of Prostate Cancer Cells by Down-Regulating the Wnt/Beta-Catenin Signaling Pathway Scientists found that microRNA (miR)-320 is significantly downregulated in prostate cancer (PCa). Overexpression of miR-320 in PCa cells decreases PCa tumorigenesis in vitro and in vivo. [Carcinogenesis] Abstract Epidermal Growth Factor Promotes Protein Degradation of Epithelial Protein Lost in Neoplasm (EPLIN), a Putative Metastasis Suppressor, during Epithelial-Mesenchymal Transition Using experimental models of prostate cancer metastasis, researchers demonstrated that epidermal growth factor could induce robust epithelial-mesenchymal transition and increase invasiveness. [J Biol Chem] Abstract | Full Article Early Growth Response Protein 1 Upregulation and Nuclear Translocation by 2’-Benzoyloxycinnamaldehyde Induces Prostate Cancer Cell Death 2’-Benzoyloxycinnamaldehyde (BCA) induces significant early growth response protein 1 (EGR1) upregulation, while EGR1 knockdown decreases the induction of these genes with concurrent alleviation of cell death by BCA. [Cancer Lett] Abstract Neuroendocrine-Derived Peptides Promote Prostate Cancer Cell Survival through Activation of IGF-1R Signaling Researchers utilized conditioned-medium from LNCaP cells, engineered to undergo neuroendocrine differentiation, and examined its effects on PC3 and LNCaP cell survival. [Prostate] Abstract Interplay of Reactive Oxygen Species, Intracellular Ca2+ Surge and Loss of Mitochondrial Homeostasis in the Apoptotic Ablation of Prostate Cancer Cells by Deoxypodophyllotoxin Using the PC-3 cell model of human prostate cancer, the authors showed that deoxypodophyllotoxin induced apoptosis via a caspase-3-dependent pathway that is activated due to dysregulated mitochondrial function. [J Cell Biochem] Abstract Effect of an All-Trans-Retinoic Acid Conjugate with Spermine on Viability of Human Prostate Cancer and Endothelial Cells In Vitro and Angiogenesis In Vivo The effect of N1,N12-bis(all-trans-retinoyl)spermine, a conjugate of all-trans-retinoic acid with spermine, on angiogenesis in vivo and viability of human endothelial and prostate cancer cells in vitro were studied. [Eur J Pharmacol] Abstract CLINICAL RESEARCH Vitamin D, Season, and Risk of Prostate Cancer: A Nested Case-Control Study within Norwegian Health Studies Researchers aimed to assess the prospective relations between serum 25-hydroxyvitamin D, serum retinol, and risk of prostate cancer. [Am J Clin Nutr] Abstract Outcomes and Trends of Prostate Biopsy for Prostate Cancer in Chinese Men from 2003 to 2011 All men who underwent prostate biopsy for prostate cancer at Huashan Hospital, Shanghai, China were evaluated. Demographic and clinical information was collected for each patient, including age, digital rectal examination, transrectal ultrasound, total prostate-specific antigen levels and free prostate-specific antigen ratio prior to biopsy. [PLoS One] Full Article |