LABORATORY RESEARCH FoxA1 Specifies Unique Androgen and Glucocorticoid Receptor Binding Events in Prostate Cancer Cells Scientists found a novel function for FoxA1 in defining the cell-type specificity of androgen receptor (AR) and glucocorticoid receptor (GR) binding events in a distinct fashion, namely, for AR in LNCaP-1F5 cells and for GR in VCaP cells. [Cancer Res] Abstract High Tissue Density of FOXP3+ T Cells Is Associated with Clinical Outcome in Prostate Cancer The authors investigated the clinical significance of the numeric density of regulatory T cells in prostate cancer as the presence of such cells in the tumor microenvironment has been linked to clinical outcome in other tumor entities. [Eur J Cancer] Abstract Inhibition of Constitutive Aryl Hydrocarbon Receptor (AhR) Signaling Attenuates Androgen Independent Signaling and Growth in (C4-2) Prostate Cancer Cells Researchers investigated the effect of sustained aryl hydrocarbon receptor signaling on androgen receptor function in prostate cancer cells. [Biochem Pharmacol] Abstract Targeted Disruption of the p160 Coactivator Interface of Androgen Receptor (AR) Selectively Inhibits AR Activity in Both Androgen-Dependent and Castration-Resistant AR-Expressing Prostate Cancer Cells AR is re-activated through multiple mechanisms including expression of constitutively active splice variants that lack hormone binding domains (HBDs). This highlights the need to develop therapies that target regions other than the HBD. Because the p160 coactivators interact most strongly with the amino-terminus of AR, scientists examined the consequences of disrupting this interaction. [Int J Biochem Cell Biol] Abstract Trefoil Factor 1 Suppression of E-Cadherin Enhances Prostate Carcinoma Cell Invasiveness and Metastasis Investigators demonstrated that trefoil factor 1 promotes prostate cancer cell migration and invasion in vitro and metastasis in vivo. [Cancer Lett] Abstract Endothelial-Rich Microenvironment Supports Growth and Branching Morphogenesis of Prostate Epithelial Cells A panel of eleven cell lines originating in normal or malignant prostate and primary prostate epithelial cells were cultured in reconstituted basement membrane matrix with or without non-proliferating but metabolically active endothelial cells. [Prostate] Abstract Single-Cell Analysis of Circulating Tumor Cells Identifies Cumulative Expression Patterns of EMT-Related Genes in Metastatic Prostate Cancer The authors tested whether circulating tumor cells expressing genes related to epithelial-mesenchymal transition (EMT) are strong predictors of metastatic prostate cancer. [Prostate] Abstract Physangulidine A, a Withanolide from Physalis angulata, Perturbs the Cell Cycle and Induces Cell Death by Apoptosis in Prostate Cancer Cells Recently, the authors reported the discovery of three new withanolides, physangulidines A-C, from Physalis angulate. In this study, they describe the biological effects of physangulidine A, which was the most active and abundant of the three new constituents. [J Nat Prod] Abstract CLINICAL RESEARCH Guideline-Discordant Androgen Deprivation Therapy in Localized Prostate Cancer: Patterns of Use in the Medicare Population and Cost Implications Researchers examined recent trends in androgen deprivation therapy use and quantified the cost of guideline-discordant ADT. [Ann Oncol] Abstract The Association between Calcium Channel Blocker Use and Prostate Cancer Outcome The association between calcium channel blocker use and prostate cancer aggressiveness at the time of radical prostatectomy (RP) and outcome after RP was examined. [Prostate] Abstract Prognostic Value of Stromal and Epithelial Periostin Expression in Human Prostate Cancer: Correlation with Clinical Pathological Features and the Risk of Biochemical Relapse or Death Periostin expression in prostate cancer and in normal specimens was evaluated in 90 patients by an immuno-reactive score based on the intensity of immunostaining and on the quantity of stained cells. [BMC Cancer] Abstract | Full Article |