LABORATORY RESEARCH Dp44mT Targets the AKT, TGF-β and ERK Pathways via the Metastasis Suppressor NDRG1 in Normal Prostate Epithelial Cells and Prostate Cancer Cells Scientists determined how the tumorigenic phosphoinositide 3-kinase/protein kinase B (PI3K/AKT), tumor-suppressive phosphatase and tensin homologue deleted on chromosome 10 and transforming growth factor-β (TGF-β) pathways are integrated via the metastasis suppressor, N-myc downstream-regulated gene-1 (NDRG1). [Br J Cancer] Full Article Novel Interaction Between the Co-Chaperone Cdc37 and Rho GTPase Exchange Factor Vav3 Promotes Androgen Receptor Activity and Prostate Cancer Growth Investigators sought to identify Vav3 binding partners in an effort to understand the molecular mechanisms underlying Vav3 enhancement of androgen receptor activity and to identify new therapeutic targets. The cell division cycle 37 homolog (Cdc37), a protein kinase-specific co-chaperone for Hsp90, was identified as a Vav3 interacting protein by yeast two hybrid screening. [J Biol Chem] Abstract The Wilms’ Tumor Gene (WT1) Regulates E-Cadherin Expression and Migration of Prostate Cancer Cells To better understand the effect of WT1 on E-cadherin expression and migration of prostate cancer (PCa) cells, scientists quantified WT1 and E-cadherin mRNA levels in normal prostate epithelial and PCa cell lines with varying migratory potential. [Mol Cancer] Abstract | Full Article Anterior Gradient 2 and 3: Two Prototype Androgen Responsive Genes Transcriptionally Upregulated by Androgens and by Estrogens in Prostate Cancer Cells The authors analyzed the effect of androgens and estrogens on the expression of AGR2 and AGR3, two highly related genes encoding secretory proteins that are expressed in prostate cancer and one of which has been associated with tumor metastasis. [FEBS J] Abstract Platelet-Derived Growth Factor-BB Accelerates Prostate Cancer Growth by Promoting the Proliferation of Mesenchymal Stem Cells Investigators report that mesenchymal stem cells promoted prostate cancer (PCa) tumor growth in vivo and cell proliferation in vitro by using PCa cell strain RM-1. [J Cell Biochem] Abstract Combining T-Cell Immunotherapy and Anti-Androgen Therapy for Prostate Cancer Scientists demonstrated that T cells can be genetically engineered to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen Muc1. CAR-Muc1 T cells were able to selectively kill Muc1-expressing human prostate cancer cells.[Prostate Cancer Prostatic Dis] Abstract Apoptosis Induction of Human Prostate Carcinoma Cells by Cordycepin through Reactive Oxygen Species-Mediated Mitochondrial Death Pathway Scientists investigated the apoptotic effects of cordycepin in human prostate carcinoma cells. They found that treatment with cordycepin significantly inhibited cell growth by inducing apoptosis in PC-3 cells. [Int J Oncol] Abstract CLINICAL RESEARCH 2-Weekly versus 3-Weekly Docetaxel to Treat Castration-Resistant Advanced Prostate Cancer: A Randomized, Phase III Trial The authors hypothesized that 2-weekly administration of docetaxel would be better tolerated than 3-weekly docetaxel in patients with castration-resistant advanced prostate cancer, and did a prospective, multicenter, randomized, Phase III study to compare efficacy and safety. [Lancet Oncol] Abstract Prostate Cancer Diagnosis among Men with Isolated High-Grade Intraepithelial Neoplasia Enrolled onto a 3-Year Prospective Phase III Clinical Trial of Oral Toremifene Researchers evaluated the efficacy of toremifene citrate in prostate cancer prevention among men with isolated high-grade prostatic intraepithelial neoplasia on biopsy. [J Clin Oncol] Abstract Enzalutamide: A Novel Anti-Androgen for Patients with Castrate Resistant Prostate Cancer In a Phase III randomized study comparing Enzalutamide to placebo in men with progressive castration resistant prostate cancer who were previously treated with docetaxel, Enzalutamide showed an improvement in overall survival. [Clin Cancer Res] Abstract |