LABORATORY RESEARCH Type 10 Soluble Adenylyl Cyclase Is Overexpressed in Prostate Carcinoma and Controls Proliferation of Prostate Cancer Cells Significant overexpression of soluble adenylyl cyclase, an alternative source of cyclic AMP, was found in human prostate carcinoma, and therefore, the contribution of this cyclase was investigated in the prostate carcinoma cell lines LNCaP and PC3. [J Biol Chem] Abstract | Press Release Role of WNT7B-Induced Non-Canonical Pathway in Advanced Prostate Cancer Investigators identified WNT7B as a direct androgen receptor target gene highly expressed in castration-resistant prostate cancer cells. [Mol Cancer Res] Abstract Differential Signaling of the GnRH Receptor in Pituitary Gonadotrope Cell Lines and Prostate Cancer Cell Lines The GnRH receptor (GnRHR) mediates the pituitary functions of GnRH, as well as its anti-proliferative effects in sex hormone-dependent cancer cells. The authors compared the signaling of GnRHR in pituitary gonadotrope cell lines vs. prostate cancer cell lines. [Mol Cell Endocrinol] Abstract Human Prostate Side Population Cells Demonstrate Stem Cell Properties in Recombination with Urogenital Sinus Mesenchyme Scientists isolated and analyzed cells digested from twelve clinical prostate specimens based on the side population assay. Prostate stem cell properties of the isolated cells were tested by serial recombination with rat urogenital mesenchyme. [PLoS One] Full Article MicroRNA-182-5p Promotes Cell Invasion and Proliferation by Down Regulating FOXF2, RECK and MTSS1 Genes in Human Prostate Cancer Researchers found that microRNA (miR)-182-5p expression was significantly higher in prostate cancer tissues and cell lines compared to normal prostate tissues and cells. Moreover, high miR-182-5p expression was associated with shorter overall survival in prostate cancer patients. [PLoS One] Full Article Androgen Up-Regulates Vascular Endothelial Growth Factor Expression in Prostate Cancer Cells via an Sp1 Binding Site Three novel androgen receptor (AR) binding sites were discovered in the Vascular Endothelial Growth Factor promoter and in vivo binding of AR to these sites was demonstrated by chromatin immunoprecipitation. [Mol Cancer] Abstract | Full Article Up-Regulated MicroRNA-143 in Cancer Stem Cells Differentiation Promotes Prostate Cancer Cells Metastasis by Modulating Fibronectin Type III Domain Containing 3B Expression The expression of microRNA (miR)-143 and the migration capability were reduced in PC-3 sphere cells and progressively increased during sphere re-adherent culture. The down-regulation of miR-143 suppressed prostate cancer cells migration and invasion in vitro and systemically inhibited metastasis in vivo. [BMC Cancer] Abstract | Full Article CLINICAL RESEARCH Short-Term versus Long-Term Hormone Therapy Plus Radiotherapy or Prostatectomy for Prostate Cancer: A Systematic Review and Meta-Analysis The authors compared the efficacy and safety of short-term versus long-term hormonotherapy plus radiotherapy or prostatectomy for prostate cancer. [J Cancer Res Clin] Abstract Phase III, Randomized, Placebo-Controlled Study of Once-Daily Oral Zibotentan (ZD4054) in Patients with Non-Metastatic Castration-Resistant Prostate Cancer This study, part of the ENTHUSE (EndoTHelin A USE) Phase III programme, evaluated the efficacy and safety of the oral specific endothelin-A receptor antagonist zibotentan vs placebo in patients with non-metastatic castration-resistant prostate cancer. [Prostate Cancer Prostatic Dis] Abstract |