LABORATORY RESEARCH 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine (PhIP)-DNA Adducts in Benign Prostate and Subsequent Risk for Prostate Cancer Despite convincing evidence that PhIP – a heterocyclic amine generated by cooking meats at high temperatures – is carcinogenic in animal models, it remains unclear whether PhIP exposure leads to increased cancer risk in humans. PhIP-DNA adduct levels were measured in specimens from 534 prostate cancer case-control pairs nested within a historical cohort of men with histopathologically benign prostate specimens. [Int J Cancer] Abstract Androgens Regulate TRAIL-Induced Cell Death in Prostate Cancer Cells via Multiple Mechanisms To clarify the role of androgens on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in prostate cancer cells, scientists investigated the effects of androgen on TRAIL-induced cell death in a dose-response manner. [Cancer Lett] Abstract Androgen Signaling Promotes Translation of TMEFF2 in Prostate Cancer Cells via Phosphorylation of the α Subunit of the Translation Initiation Factor 2 Scientists showed that translation of transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) is regulated by androgens. Addition of physiological concentrations of dihydrotestosterone to prostate cancer cell lines increases translation of endogenous TMEFF2 or transfected TMEFF2-Luciferase fusions, and this effect requires the presence of upstream open reading frames in the 5′-untranslated region of TMEFF2. [PLoS One] Full Article Lumican Expression, Localization and Antitumor Activity in Prostate Cancer Investigators analyzed the role of lumican in the pathogenesis of prostate cancer both in vivo and in vitro. Overall lumican up-regulation was observed in the primary tumors analyzed through both real-time PCR and immunostaining. [Exp Cell Res] Abstract Expression and Role of the Angiotensin II AT2 Receptor in Human Prostate Tissue: In Search of a New Therapeutic Option for Prostate Cancer Angiotensin II type 2 receptor (AT2R) and its AT2R-interacting protein expression were assessed on non-tumoral and tumoral human prostate using tissue microarray immunohistochemistry, binding assay, and Western blotting. AT2R’s effect on cell number was measured in primary cultures of epithelial cells from non-tumoral human prostate. [Prostate] Abstract The Vav3 Oncogene Enhances the Malignant Potential of Prostate Cancer Cells under Chronic Hypoxia The authors identified a key molecule, the Vav3 oncogene, and investigated the effects of Vav3 overexpression on cancer cell growth and malignant behavior and the possible apoptosis-inducing effect of Vav3 expression knockdown by small interfering ribonucleic acid in LNCaP cells under chronic hypoxia. [Urol Oncol] Abstract Wild-Type p53 Suppresses the Epithelial-Mesenchymal Transition and Stemness in PC-3 Prostate Cancer Cells by Modulating miR-145 Scientists found that ectopic expression of wild-type p53 inhibited the migration and invasion, and enhanced the adhesion of p53-null PC-3 cells derived from prostate cancer bone metastasis. [Int J Oncol] Abstract CLINICAL RESEARCH Long-Term Prostate-Specific Antigen Velocity in Improved Classification of Prostate Cancer Risk and Mortality It remains unclear whether adding long-term prostate-specific antigen velocity (PSAV) to baseline PSA values improves classification of prostate cancer (PCa) risk and mortality in the general population. Researchers examined whether long-term PSAV improves classification of PCa risk and mortality in the general population. [Eur Urol] Abstract Laparoscopic versus Open Bilateral Intrafascial Nerve-Sparing Radical Prostatectomy after TUR-P for Incidental Prostate Cancer: Surgical Outcomes and Effect on Postoperative Urinary Continence and Sexual Potency 125 nerve-sparing laparoscopic radical prostatectomies and 128 nerve-sparing retropubic radical prostatectomies for incidental prostate cancer diagnosed after TUR-P were performed. Demographic data, peri- and postoperative measurements and functional outcomes were compared. [World J Urol] Abstract |