LABORATORY RESEARCH Downregulation of Dickkopf-3 Disrupts Prostate Acinar Morphogenesis through TGF-β/Smad Signaling To gain insight into the function of Dickkopf-3 (Dkk-3) in the prostate, researchers compared the prostates of Dkk3 null mice with those of control littermates. They found increased proliferation of prostate epithelial cells in the mutant mice and changes in prostate tissue organization. [J Cell Sci] Abstract The Transcription Factor SPDEF Is Required for E-Cadherin Expression in Prostate Cancer Cells The authors evaluated the relationship between SAM Pointed Domain ETS transcription Factor (SPDEF) and E-Cadherin expression in an effort to better understand the mechanism of action of SPDEF in prostate tumor-cell invasion and metastasis. [J Biol Chem] Abstract ARF Represses Androgen Receptor Transactivation in Prostate Cancer Scientists provide evidence that p14 alternative reading frame (ARF) physically interacts with androgen receptor (AR) and functions as an AR corespressor in both an androgen-dependent and androgen-independent manner. [Mol Endocrinol] Abstract Expression of Lysophosphatidic Acid Receptor 1 and Relation with Cell Proliferation, Apoptosis, and Angiogenesis on Preneoplastic Changes Induced by Cadmium Chloride in the Rat Ventral Prostate Researchers evaluated the immunoexpression of lysophosphatidic acid, cell proliferation, apoptosis, and angiogenesis markers in preneoplastic lesions induced with cadmium chloride in rat prostate. [PLoS One] Full Article Overexpression of a Key Regulator of Lipid Homeostasis, Scap, Promotes Respiration in Prostate Cancer Cells Investigators examined LNCaP cells overexpressing the sterol regulatory element-binding protein 2 (SREBP-2) regulator, Scap; although having higher SREBP-2 activity, these cells displayed higher respiration. [FEBS Lett] Abstract miR-152 Controls Migration and Invasive Potential by Targeting TGFα in Prostate Cancer Cell Lines Aberrant MicroRNA-152 (miR-152) expression has been frequently reported in various malignant tumors. However, the mechanism of miR-152 in prostate cancer (PCa) remains unclear. Researchers aimed to determine the function of miR-152 in PCa cells and identify the novel molecular targets regulated by miR-152. [Prostate] Abstract Noradrenaline Induces Binding of Clathrin Light Chain A to α1-Adrenoceptors in the Human Prostate The authors investigated the expression and α1-adrenoceptor binding of clathrins, caveolin, and their cofactors in the human prostate. [Prostate] Abstract CLINICAL RESEARCH Retrospective Evaluation Reveals that Long-term Androgen Deprivation Therapy Improves Cause-Specific and Overall Survival in the Setting of Dose-Escalated Radiation for High-Risk Prostate Cancer The relationship between androgen deprivation therapy use and duration with biochemical failure, metastatic failure, prostate cancer-specific mortality, non-prostate cancer death, and overall survival was assessed as a function of pretreatment characteristics, comorbid medical illness, and treatment using Fine and Gray’s cumulative incidence methodology. [Int J Radiat Oncol Biol Phys] Abstract Long-Term Follow-Up of a Phase II Trial of Chemotherapy plus Hormone Therapy for Biochemical Relapse after Definitive Local Therapy for Prostate Cancer Treatment was four cycles of docetaxel every three weeks and estramustine three times a day followed by 15 months of goserelin acetate/bicalutamide. The primary endpoint was the proportion with prostate-specific antigen <0.1 with recovered testosterone five years after completion of therapy. [Urology] Abstract |