LABORATORY RESEARCH IL-6 Sensitizes Prostate Cancer to the Antiproliferative Effect of IFNa2 through IRF9 To identify novel pathways that are triggered by interleukin (IL)-6, researchers performed a gene expression profiling of two prostate cancer (PCa) cell lines, LNCaP and MDA PCa 2b, treated with 5 ng/ml IL-6. Interferon regulatory factor (IRF)9 was identified as one of the most prevalent IL-6 regulated genes in both cell lines. [Endocr Relat Cancer] Abstract The Tumor Suppressor miR-34c Targets MET in Prostate Cancer Cells Scientists set out to characterize the mechanisms by which microRNA (miR)-34c deregulation contributes to prostate cancer progression. They confirmed the inhibitory effect of miR-34c on both MET transcript and protein levels. [Brit J Cancer] Abstract Transcriptional Regulation of CXCR4 in Prostate Tumor Cells: Significance of TMPRSS2-ERG Fusions The authors investigated molecular mechanisms of ERG-mediated CXCR4 promoter activation, phosphorylation of ERG by intracellular kinases and subsequent CXCR4 expression, as well as expression of ERG and CXCR4 in human prostate tumor tissues. [Mol Cancer Res] Abstract Inhibition of Cell Adhesion by an Anti-Cadherin 11 Antibody Prevents Bone Metastasis Downregulation of cadherin-11 inhibits interaction of prostate cancer (PCa) cells with osteoblasts in vitro and homing of PCa cells to bone in an animal model of metastasis. [Mol Cancer Res] Abstract RhoGDIa Downregulates Androgen Receptor Signaling in Prostate Cancer Cells Researchers examined the effect of GDP Dissociation Inhibitor alpha (GDIa) on androgen receptor (AR) signaling in prostate cancer cells. They identified GDIa as a negative regulator of AR signaling pathway. [Prostate] Abstract Alpha-Tomatine Synergizes with Paclitaxel to Enhance Apoptosis of Androgen-Independent Human Prostate Cancer PC-3 Cells In Vitro and In Vivo Combined treatment with a sub-toxic dose of a-tomatine and paclitaxel significantly decreased cell viability with concomitant increase in the percentage of apoptotic PC-3 cells. [Phytomedicine] Abstract | Graphical Abstract Glucose-Regulated Protein 78 Mediates Hormone-Independent Prostate Cancer Progression and Metastasis through Maspin and COX-2 Expression Investigators found that the expression levels of glucose-regulated protein 78 were higher in PC-3 cells than in DU-145 cells. [Tumor Biol] Abstract Chemokine Receptor Expression on Integrin-Mediated Stellate Projections of Prostate Cancer Cells in 3D Culture Scientists report that CXCR7 and CXCR4 were co-expressed in LNCaP, DU145 and PC3 cell lines in 2D culture. When cultured in 3D using Matrigel, a marked up-regulation of both receptors was observed in PC3 cells. [Cytokine] Abstract Reactive Oxygen Species Mediate Isoalantolactone-Induced Apoptosis in Human Prostate Cancer Cells Researchers found that isoalantolactone inhibits growth of both androgen-sensitive as well as androgen-independent prostate cancer cells in a dose-dependent manner. [Molecules] Abstract | Full Article CLINICAL RESEARCH The Effect of Prior Androgen Synthesis Inhibition on Outcomes of Subsequent Therapy with Docetaxel in Patients with Metastatic Castrate-Resistant Prostate Cancer As measured by overall survival, progression-free survival, prostate-specific antigen, and the objective response rate, there was no evidence that prior treatment with ketoconazole had an impact on the clinical outcomes of patients with metastatic castration-resistant prostate cancer who received subsequent docetaxel-based therapy. [Cancer] Abstract Phase II Trial of Zoledronic Acid Combined with Androgen-Deprivation Therapy for Treatment-Naïve Prostate Cancer with Bone Metastasis The authors conducted a Phase II study to investigate the benefits of combined zoledronic acid and androgen deprivation therapy in treatment-naïve prostate cancer with bone metastasis. [Int J Clin Oncol] Abstract |