Prostate Cell News Volume 4.37 | Sep 27 2013

The Modulation of Attachment, Growth and Morphology of Cancerous Prostate Cells by Polyelectrolyte Nanofilms
The behavior of cancerous epithelial prostatic cells (PC3) growing on polyelectrolytes coatings was compared to the behavior of immortalized normal prostatic cells (PNT-2). The proliferation rate of PC3 cells was reduced on the poly(allylamine hydrochloride)-terminated surface and slightly increased on the poly(sodium 4-styrenesulphonate) coatings. [Biomaterials] Full Article

Protein Inhibitor of Activated Signal 1-Modulated Smad2/4 Complex Activation Is Involved in Zinc-Induced Cancer Cell Apoptosis
Scientists investigated the therapeutic effect of zinc in prostate cancer chemoprevention for the first time. Exposure to zinc induced apoptosis and resulted in transactivation of p21^WAF1/Cip1 in a Smad-dependent and p53-independent manner in prostate cancer cells. [Cell Death Dis] Full Article

Apigenin Inhibits Prostate Cancer Progression in TRAMP Mice via Targeting PI3K/Akt/FoxO Pathway
Researchers showed that apigenin suppressed prostate tumorigenesis in TRAMP mice through the PI3K/Akt/forkhead box O (FoxO) signaling pathway. [Carcinogenesis] Abstract

Deubiquitinating Enzyme Usp12 Is a Novel Co-Activator of the Androgen Receptor
Researchers demonstrated that ubiquitin specific protease 12 (Usp12), in complex with Uaf-1 and WDR20, deubiquitinates the androgen receptor (AR) to enhance receptor stability and transcriptional activity. They showed that Usp12 acts in a pro-proliferative manner by stabilizing AR and enhancing its cellular function. [J Biol Chem] Abstract | Full Article

Metastatic Prostate Cancer Cell-Specific Phage-Like Particles as a Targeted Gene-Delivery System
Phage clone EPTHSWAT (designated by the sequence of inserted peptide) was found to be most selective for PC-3M cells and was observed to internalize PC-3M cells as revealed by immunofluorescence microscopy and electron microscopy. [J Nanobiotechnology] Abstract | Full Article

Early Human Prostate Adenocarcinomas Harbor Androgen-Independent Cancer Cells
Investigators report the propagation of cancer initiating cells directly from Stage I human prostate cancer tissue without selection or genetic manipulation. [PLoS One] Full Article

Influence of Lycopene on Cell Viability, Cell Cycle, and Apoptosis of Human Prostate Cancer and Benign Hyperplastic Cells
Using MTT assay, researchers observed a decrease of cell viability in all cancer cell lines after treatment with lycopene, which decreased the percentage of cells in G0/G1 phase and increased in S and G2/M phases after 96 hours of treatment in metastatic prostate cancer cell lineages. [Nutr Cancer] Abstract

Selenium Biomarkers in Prostate Cancer Cell Lines and Influence of Selenium on Invasive Potential of PC3 Cells
Scientists found that the maximum levels of glutathione peroxidase 1 activity and thioredoxin reductase 1 expression were reached at lower selenium concentrations in LNCaP compared to PC3 cells, and PC3 compared to DU145 cells. [Front Oncol] Abstract

CLINICAL RESEARCH

Genetic Variation in IL-16 miRNA Target Site and Time to Prostate Cancer Diagnosis in African-American Men
Researchers evaluated genetic variants in genes encoding microRNA (miRNA) binding sites for informing of time to prostate cancer diagnosis among ethnically diverse, high-risk men undergoing prostate cancer screening. [Prostate Cancer P D] Abstract

Safety of Abiraterone Acetate in Castration-Resistant Prostate Cancer Patients with Concomitant Cardiovascular Risk Factors
Scientists evaluated the safety profile of abiraterone acetate in metastatic castration-resistant prostate cancer men with cardiovascular comorbidity, as little conclusive safety data are available in this patient subset. [Am J Clin Oncol] Abstract

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Exelixis Announces Full Patient Enrollment Target Has Been Achieved for COMET-1
Exelixis, Inc. announced that the enrollment target of 960 patients has been reached for COMET-1, the company’s Phase III pivotal trial of cabozantinib in patients with metastatic castration-resistant prostate cancer. [Exelixis, Inc.] Press Release

Prostate Cancer Foundation Announces New Urine Test for Prostate Cancer Available
A new urine test for prostate cancer that measures minute fragments of RNA is now commercially available to men nationwide through the University of Michigan MLabs. The new test-Mi-Prostate Score-improves the utility of the prostate specific antigen blood test, increases physicians’ ability to pick out high-risk prostate tumors from low-risk tumors in patients, and may help tens of thousands of men avoid unnecessary biopsies. [EurekAlert!] Press Release

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Postdoctoral Research Associates – Tumor Immune Evasion Mechanism and Inflammation (Hollings Cancer Center)

Postdoctoral Fellow – Prostate Cancer and Head & Neck Cancer (University of Maryland Baltimore)

Research Associate – Prostate Cancer (University of Virginia)

Postdoctoral Position – Prostate Molecular Biology and Cancer Biology (University of California San Francisco)

Postdoctoral Position – Prostate Cancer Biology (University Of Rochester School Of Medicine)

Postdoctoral Position – Cancer Genomics and Epigenomics (Ontario Cancer Institute / Princess Margaret Hospital)

Research Associate II – Anti-Cancer Agents for the Treatment of Prostate Cancer (Johnson & Johnson)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Technologist – Mesenchymal Cell Research (STEMCELL Technologies Inc.)

Research Technologist – Cell Culture Media & Matrices (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)

Quality Control Analyst – Media (STEMCELL Technologies Inc.)

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