LABORATORY RESEARCH PRH/HHex Inhibits the Migration of Breast and Prostate Epithelial Cells through Direct Transcriptional Regulation of Endoglin Researchers showed that proline-rich homeodomain protein (PRH) is involved in the regulation of cell migration and cancer cell invasion. They showed for the first time that PRH is expressed in prostate cells and that a decrease in PRH protein levels increases the migration of normal prostate epithelial cells. [Oncogene] Abstract miRNA-296-3p-ICAM-1 Axis Promotes Metastasis of Prostate Cancer by Possible Enhancing Survival of Natural Killer Cell-Resistant Circulating Tumor Cells Scientists found that the expression level of microRNA-296-3p is much lower in the non-metastatic human prostate cancer cell line P69 than that in the highly metastatic cell line M12, which is derived from P69. [Cell Death Dis] Full Article A Naturally-Derived Small Molecule Disrupts Ligand-Dependent and Ligand-Independent Androgen Receptor Signaling in Human Prostate Cancer Cells Scientists showed that mahanine possesses the ability to inhibit ligand-dependent and ligand-independent androgen receptor (AR) transactivation, leading to a prominent decline in AR target gene expression. Mahanine treatment causes a time- and dose- dependent decline in AR protein levels, including truncated AR splice variants, in a panel of androgen-responsive and androgen-independent prostate cancer cells. [Mol Cancer Ther] Abstract TBLR1 as an AR Coactivator Selectively Activates AR Target Genes to Inhibit Prostate Cancer Growth Scientists characterized TBLR1 as a coactivator of androgen receptor (AR) in prostate cancer cells and the activation is both phosphorylation and 19S proteosome dependent. They showed that TBLR1 physically interacts with AR and directly occupies the androgen response elements of affected AR target genes in an androgen-dependent manner. [Endocr Relat Cancer] Abstract MicroRNA-663 Induces Castration-Resistant Prostate Cancer Transformation and Predicts Clinical Recurrence Researchers report that microRNA (miR)-663 is upregulated in castration-resistant prostate cancer tissues. Overexpression of miR-663 in prostate LNCaP cells promotes cell proliferation and invasion, neuroendocrine differentiation, and reduction in dihydrotestosterone-induced upregulation of prostate-specific antigen expression. [J Cell Physiol] Abstract Pifithrin-μ, an Inhibitor of Heat-Shock Protein 70, Can Increase the Antitumor Effects of Hyperthermia Against Human Prostate Cancer Cells Researchers investigated the sensitizing effect of pifithrin-μ, a small molecule inhibitor of heat-shock protein 70 (HSP70), when three human prostate cancer cell lines were treated with hyperthermia (HT). All cell lines constitutively expressed HSP70, and HT further increased its expression in LNCaP and DU-145. [PLoS One] Full Article Prostate Cancer Derived Prostatic Acid Phosphatase Promotes an Osteoblastic Response in the Bone Microenvironment To demonstrate that prostatic acid phosphatase (PAP) promotes mineralization, scientists stimulated MC3T3-E1 cells with PAP and observed increased mineralization, which could be blocked with the specific PAP inhibitor, phosphonic acid. [Clin Exp Metastasis] Abstract Inhibition of PARP1 by Small Interfering RNA Enhances Docetaxel Activity against Human Prostate Cancer PC3 Cells Scientists revealed that inhibition of poly(ADP-ribose) polymerase 1 (PARP1) by small interfering RNA could enhance docetaxel’s activity against PC3 cells, which is associated with an accelerate repression of EGF/Akt/FOXO1 signaling pathway. [Biochem Biophys Res Commun] Abstract CLINICAL RESEARCH Long-Term Survival and Biomarker Correlates of Tasquinimod Efficacy in a Multicenter Randomized Study of Men with Minimally Symptomatic Metastatic Castration-Resistant Prostate Cancer Tasquinimod is an oral immunomodulatory, anti-angiogenic, and anti-metastatic agent that delayed metastatic disease progression in a randomized placebo-controlled Phase II trial in men with metastatic castration-resistant prostate cancer. Here, researchers report long-term survival with biomarker correlates from this trial. [Clin Cancer Res] Abstract | Press Release Immunohistochemical Expression of PDGFR, VEGF-C, and Proteins of the mToR Pathway before and after Androgen Deprivation Therapy in Prostate Carcinoma: Significant Decrease after Treatment Platelet-derived growth factor receptor (PDGFR), vascular endothelial growth factor C (VEGF-C), mammalian target of rapamycin (mToR), and p70 ribosomal protein S6 kinase 1 expression was significantly reduced after androgen deprivation therapy (ADT), whereas expression of epidermal growth factor receptor, human epidermal growth factor receptor 2, and carbonic anhydrase IX was not influenced by ADT. [Target Oncol] Abstract Diethylstilbestrol for the Treatment of Patients with Castration-Resistant Prostate Cancer: Retrospective Analysis of a Single Institution Experience Investigators evaluated the efficacy and safety of diethylstilbestrol (DES) as treatment for patients with castration-resistant prostate cancer and to identify predicting factors of response to DES. [Oncol Rep] Abstract |