LABORATORY RESEARCH Identification of a Cyclin D1 Network in Prostate Cancer that Antagonizes Epithelial-Mesenchymal Restraint Cyclin D1 inactivation reduced cellular proliferation in the murine prostate in vivo and in isogenic oncogene-transformed prostate cancer cell lines. [Cancer Res] Abstract SOCS2 Correlates with Malignancy and Exerts Growth Promoting Effects in Prostate Cancer Functionally, suppressor of cytokine signaling 2 (SOCS2) knockdown inhibited prostate cancer cell proliferation and xenograft growth in a CAM assay. Decreased cell growth after SOCS2 downregulation was associated with cell-cycle arrest and apoptosis. [Endocr Relat Cancer] Abstract Pirin Down-Regulates the EAF2/U19 Protein and Alleviates Its Growth Inhibition in Prostate Cancer Cells Pirin co-immunoprecipitated with ELL associated factor 2 (EAF2/U19) and the overexpressed Pirin decreased the expression level of EAF2/U19 protein in prostate cancer cell lines LNCaP and PC3. [Prostate] Abstract EP2 Signaling Mediates Suppressive Effects of Celecoxib on Androgen Receptor Expression and Cell Proliferation in Prostate Cancer Researchers investigated the suppression of prostate cancer growth by celecoxib and elucidated the biological relevance of the inhibited pathway in prostate cancer cell lines. [Prostate Cancer Prostatic Dis] Abstract D-Glucuronyl C5-Epimerase Cell Type Specifically Affects Angiogenesis Pathway in Different Prostate Cancer Cells To investigate the potential cancer-promoting effect of d-glucuronyl C5-epimerase (GLCE) in prostate cancer, GLCE was ectopically re-expressed in morphologically different LNCaP and PC3 prostate cancer cells. [Tumor Biol] Abstract The Tumor-Suppressive MicroRNA-143/145 Cluster Inhibits Cell Migration and Invasion by Targeting GOLM1 in Prostate Cancer Scientists investigate the functional significance of the microRNA (miR)-143/145 cluster in prostate cancer (PCa) cells and to identify novel targets regulated by these cluster miRNAs in PCa. [J Hum Genet] Abstract Activation of RhoA,B,C by Yersinia Cytotoxic Necrotizing Factor (CNFy) Induces Apoptosis in LNCaP Prostate Cancer Cells Researchers used the bacterial toxins CNFy and CNF1, which specifically and directly activate Rho GTPases by deamidation of a single glutamine. They asked whether these Rho activators could induce apoptosis in LNCaP cells. [Toxins] Abstract | Full Article MiR-181a Contributes to Bufalin-Induced Apoptosis in PC-3 Prostate Cancer Cells Bufalin was found to induce the expression of miR-181a, a small non-coding RNA believed to induce apoptosis by repressing its target gene, BCL-2. In prostate cancer PC-3cell line, bufalin-induced apoptosis can be largely attenuated by a miR-181a inhibitor, which blocked bufalin-induced Bcl-2 reduction and caspase-3 activation. [BMC Complement Altern Med] Full Article CLINICAL RESEARCH Intermittent Versus Continuous Cyproterone Acetate in Bone Metastatic Prostate Cancer: Results of a Randomized Trial To compare intermittent treatment versus continuous treatment using cyproterone acetate in bone metastatic prostate cancer patients, investigators conducted an open-label, multicenter randomized trial. [World J Urol] Abstract Enzalutamide Treatment in Patients with Metastatic Castration-Resistant Prostate Cancer Progressing after Chemotherapy and Abiraterone Acetate Researchers aimed to record prostate-specific antigen (PSA) response and overall survival (OS) for a group of metastatic castration-resistant prostate cancer (mCRPC) patients treated with enzalutamide following progression after abiraterone treatment in the post-chemotherapy setting. [Scand J Urol] Abstract |