Prostate Cell News Volume 5.06 | Feb 21 2014

Species-Specific Homing Mechanisms of Human Prostate Cancer Metastasis in Tissue Engineered Bone
Researchers aimed to engineer a morphologically and functionally intact humanized organ bone which can serve as a homing site for human prostate cancer cells. [Biomaterials] Abstract

Anticancer Effects of Gemcitabine Are Enhanced by Co-Administered iRGD Peptide in Murine Pancreatic Cancer Models that Overexpressed Neuropilin-1
Investigators report a novel combination chemotherapy using gemcitabine (GEM) and internalized-RGD (iRGD) peptide, which enhances tumor-specific drug penetration by binding neuropilin-1 (NRP1) receptor. A total of five pancreatic cancer murine models (two cell line-based xenografts and three tumor grafts) were treated with either GEM alone or GEM plus iRGD peptide. [Br J Cancer] Abstract

Paracrine Interactions between LNCaP Prostate Cancer Cells and Bioengineered Bone in 3D In Vitro Culture Reflect Molecular Changes during Bone Metastasis
To better understand the pathophysiology of bone metastasis, scientists have established and validated a 3D indirect co-culture model to investigate the paracrine interactions between prostate cancer cells and human osteoblasts. [Bone] Abstract

Subditine, a New Monoterpenoid Indole Alkaloid from Bark of Nauclea subdita (Korth.) Steud. Induces Apoptosis in Human Prostate Cancer Cells
Data demonstrated that the new compound subditine exerts anti-proliferative effect on LNCaP and PC-3 human prostate cancer cells through induction of apoptosis. [PLoS One] Full Article

Autophagy Pathway Is Required for IL-6 Induced Neuroendocrine Differentiation and Chemoresistance of Prostate Cancer LNCaP Cells
To clarify the effect of autophagy on neuroendocrine differentiation, androgen-sensitive prostate cancer LNCaP cells were examined. Treatment of LNCaP cells with IL-6 resulted in an induction of autophagy. [PLoS One]
Full Article

Enhanced Detection of Metastatic Prostate Cancer Cells in Human Plasma with Lipid Bodies Staining
Energy metabolism was examined as a function of incubation in nutrient-rich plasma in prostate metastatic cancer cells LNCaP and non-transformed prostate epithelial cells RWPE1. Uptake kinetics of a fluorescent glucose analog and lipophilic dyes were measured in both cell lines, as well as in peripheral blood mononuclear cells. [BMC Cancer] Full Article

CXCR4 and PTEN Are Involved in the Anti-Metastatic Regulation of Anethole in DU145 Prostate Cancer Cells
Researchers aimed to understand the anti-metastatic effect of anethole through C-X-C chemokine receptor type 4 (CXCR4)/tumor suppressor phosphatase and tensin homologue (PTEN) axis in DU145 prostate cancer cells. [Biochem Biophys Res Commun] Abstract

CLINICAL RESEARCH

Frequent Germline Deleterious Mutations in DNA Repair Genes in Familial Prostate Cancer Cases Are Associated with Advanced Disease
The authors used second-generation sequencing technology to assess the frequency of deleterious mutations in 22 tumor suppressor genes in familial prostate cancer (PrCa) and estimate the relative risk of PrCa if these genes are mutated. [Brit J Cancer] Abstract | Press Release

Long Term Oncologic Outcomes of a Phase II Trial of Neoadjuvant Chemohormonal Therapy followed by Radical Prostatectomy for Patients with Clinically Localized, High-Risk Prostate Cancer
High-risk PCa patients treated with neoadjuvant chemohormonal therapy followed by prostatectomy experienced a trend toward improvement in metastatic-free and overall survival when compared with high-risk patients undergoing prostatectomy alone; however this trend did not reach significance. [BJU Int] Abstract

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Hormel Institute Researcher’s Work Highlighted Nationally
Promising research focused on effectively attacking a form of prostate cancer resistant to chemotherapy is being recognized nationally by the U.S. Department of Defense. Dr. Mohammad Saleem had work recently featured as one of three prostate cancer research projects included in the Department of Defense’s “2014 Research Highlights” section. [The Hormel Institute] Press Release

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Postdoctoral Fellow – Biomarker Discovery In Prostate Cancer (University of California, San Francisco)

Postdoctoral Position- Cancer Biology/Genomics (Weill Cornell Medical College)

Experienced Researcher – Detection of Prostate Cancer Biomarkers (Dublin City University)

Postdoctoral Fellow – Role of Mitochondria in Cancer Progression (Baylor College of Medicine)

Postdoctoral Position – Prostate Cancer (Roswell Park Cancer Institute)

Postdoctoral Position – Prostate Molecular Oncology (Trinity College Dublin)

Postgraduate Position – Chemokine Receptor Induced Cell Migration (University of East Anglia)

Graduate Student Position – Epigenetics and Chromatin (University of Victoria)

Postdoctoral Fellow – Mechanism of Prostate Cancer Bone Metastasis (Georgia Regents University)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)

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