LABORATORY RESEARCH Loss of Dlg5 Expression Promotes the Migration and Invasion of Prostate Cancer Cells via Girdin Phosphorylation Researchers demonstrated that Dlg5 is frequently downregulated in prostate cancer. They showed that Dlg5 is involved in the regulation of cell migration and cancer cell invasion. [Oncogene] Abstract Autophagic Flux Determines Cell Death and Survival in Response to Apo2 Ligand/TRAIL (Dulanermin) Researchers investigated whether SQSTM1/p62 overexpression, as a marker of autophagic flux, was related to aggressiveness of human prostate cancer (PCa) and whether autophagy regulated the treatment response in sensitive but not resistant PCa cell lines. [Mol Cancer] Full Article Tissue Transglutaminase Expression Promotes Castration-Resistant Phenotype and Transcriptional Repression of Androgen Receptor Investigators report that human prostate cancer cell lines with low expression of androgen receptor had high basal levels of tissue transglutaminase expression. [Eur J Cancer] Abstract The N-Terminal Domain of the Androgen Receptor Drives Its Nuclear Localization in Castration-Resistant Prostate Cancer Cells Since the N-terminal domain (NTD) of androgen receptor (AR) plays a role in transactivation under androgen-depleted conditions, scientists investigated the role of NTD in AR nuclear localization in castration-resistant prostate cancer. [J Steroid Biochem Mol Biol] Abstract NVP-BEZ235, A Dual PI3K/mTOR Inhibitor, Induces Cell Death through Alternate Routes in Prostate Cancer Cells Depending on the PTEN Genotype Researchers investigated how the PTEN genotype affected the antitumor effect of NVP-BEZ235 in human prostate cancer cells. [Apoptosis] Abstract Celastrol Blocks Interleukin-6 Gene Expression via Downregulation of NF-?B in Prostate Carcinoma Cells Scientists evaluated the molecular mechanisms of celastrol on cell proliferation and interleukin-6 gene expression in prostate carcinoma cells. [PLoS One] Full Article Gene Expression Profiling Associated with Angiotensin II Type 2 Receptor-Induced Apoptosis in Human Prostate Cancer Cells Researchers used PCR Array analysis to determine the gene and microRNA expression profiles in human prostate cancer cell lines transduced with angiotensin II type 2 receptor recombinant adenovirus. [PLoS One] Full Article CLINICAL RESEARCH Epithelial-to-Mesenchymal Transition Mediates Docetaxel Resistance and High Risk of Relapse in Prostate Cancer Scientists assessed tumor cells from patients with prostate cancer participating in a Phase II neoadjuvant docetaxel and androgen deprivation trial to identify mediators of resistance. [Mol Cancer Ther] Abstract The Impact of Pathologic Staging on the Long-Term Oncologic Outcomes of Patients with Clinically High-Risk Prostate Cancer In the prostate-specific antigen screening era, approximately 15% of US men still present with clinically high-risk prostate cancer (PC). However, high-risk PC may be downgraded/downstaged at radical prostatectomy (RP), making additional therapy unnecessary. The authors tested the oncologic outcomes in men with clinically high-risk disease stratified on RP pathology. [Cancer] Abstract Ganglioside Disialosyl Globopentaosylceramide Is an Independent Predictor of PSA Recurrence-Free Survival following Radical Prostatectomy Researchers investigated disialosyl globopentaosylceramide (DSGb5) expression in prostate tissues and the relationship between DSGb5 expression and clinicopathological characteristics of prostate cancer patients. [Prostate Cancer Prostatic Dis] Abstract |