LABORATORY RESEARCH Natural Compound Alternol Induces Oxidative Stress-Dependent Apoptotic Cell Death Preferentially in Prostate Cancer Cells Researchers evaluated the anti-cancer effect of a recently isolated natural compound Alternol in multiple prostate cancer cell lines with the properties of advanced prostate cancers in comparison to prostate-derived non-malignant cells. [Mol Cancer Ther] Abstract | Full Article Prostate Tumor OVerexpressed-1 (PTOV1) Down-Regulates HES1 and HEY1 Notch Targets Genes and Promotes Prostate Cancer Progression Knockdown of PTOV1 in prostate epithelial cells and HaCaT skin keratinocytes caused the upregulation, and overexpression of PTOV1 the downregulation of the Notch target genes HEY1 and HES1, suggesting that PTOV1 counteracts Notch signaling. [Mol Cancer] Abstract | Full Article Methylation of the PMEPA1 Gene, a Negative Regulator of the Androgen Receptor in Prostate Cancer Researchers focused on epigenetic mechanisms of reduced prostate transmembrane protein androgen induced (PMEPA1) expression in the cancer of the prostate (CaP). Cell culture-based studies demonstrated that decitabine restores PMEPA1 expression in androgen receptor-positive CaP cell lines. [Epigenetics] Full Article 6-Shogaol from Dried Ginger Inhibits Growth of Prostate Cancer Cells Both In Vitro and In Vivo through Inhibition of STAT3 and NF-?B Signaling The effect of 6-Shogaol (6-SHO) on the growth of prostate cancer (PCa) cells was investigated. 6-SHO effectively reduced survival and induced apoptosis of cultured human and mouse PCa cells. [Cancer Prev Res] Abstract Inactivation of ATP Citrate Lyase by Cucurbitacin B, a Bioactive Compound from Cucumber, Inhibits Prostate Cancer Growth Scientists reported that cucurbitacin B (CuB) significantly and specifically inhibited prostate cancer cell growth with low IC50, accompanied by marked apoptosis, whereas normal human prostate epithelial cells were CuB-insensitive. [Cancer Lett] Abstract A General Synthetic Strategy and the Anti-Proliferation Properties on Prostate Cancer Cell Lines for Natural Phenylethanoid Glycosides A preliminary study of the anti-proliferation properties of the PhG compounds echinacoside, acteoside, calceolarioside-A and calceolarioside-B was performed; acteoside exhibited the best inhibition on the prostatic cancer cell proliferation. [Org Biomol Chem] Abstract Linc00963: A Novel, Long Non-Coding RNA Involved in the Transition of Prostate Cancer from Androgen-Dependence to Androgen-Independence Researchers investigated the long non-coding RNAs expression profiles of the indolent, androgen-dependent LNCaP cell line to the aggressive metastatic, androgen-independent C4-2 cell line using microarray technology. [Int J Oncol] Abstract Mitochondrial Structure Alteration in Human Prostate Cancer Cells upon Initial Interacting with a Chemopreventive Agent Phenethyl Isothiocyanate Human prostate cancer LNCaP cells were exposed to phenethyl isothiocyanate and the effects on cellular fine structure examined by transmission electron microscopic studies. [Cancer Cell Int] Abstract | Full Article CLINICAL RESEARCH External Validation of a Prognostic Model Predicting Overall Survival in Metastatic Castrate-Resistant Prostate Cancer Patients Treated with Abiraterone A prognostic model was derived from the population of the COU-AA-301 Phase III trial for metastatic castrate-resistant prostate cancer patients treated with abiraterone after docetaxel, and it stratifies patients into three risk groups based on clinical parameters. [Eur Urol] Abstract A Randomized Phase II Efficacy and Safety Study of Vandetanib (ZD6474) in Combination with Bicalutamide Versus Bicalutamide Alone in Patients with Chemotherapy Naïve Castration-Resistant Prostate Cancer Scientists investigated the efficacy and safety of combining vandetanib, an orally available multi-targeted tyrosine kinase inhibitor of vascular endothelial growth factor receptor-2 and epidermal growth factor receptor, with bicalutamide in patients with metastatic castration-resistant prostate cancer. [Invest New Drugs] Abstract |