LABORATORY RESEARCH G Protein-Coupled Receptor Kinase GRK5 Phosphorylates Moesin and Regulates Metastasis in Prostate Cancer Researchers report an important contributory role for GRK5 in human prostate cancer. Inhibition of GRK5 kinase activity attenuated the migration and invasion of prostate cancer cells and, concordantly, increased cell attachment and focal adhesion formation. [Cancer Res] Abstract Aldehyde Dehydrogenase 3A1 Associates with Prostate Tumorigenesis Aldehyde dehydrogenase (ALDH)3A1 expression was analyzed in various prostate cancer (PC) cell lines. In comparison with the non-stem counterparts, a robust upregulation of ALDH3A1 was observed in DU145-derived PC stem cells. [Br J Cancer] Abstract Galiellalactone Is a Direct Inhibitor of STAT3 in Prostate Cancer Cells Galiellalactone inhibited STAT3 binding to DNA in DU145 cell lysates without affecting phosphorylation status of STAT3. [J Biol Chem] Abstract | Full Article Carbohydrate Sequence of the Prostate Cancer-Associated Antigen F77 Assigned by a Mucin O-Glycome Designer Array The authors made multifaceted approaches to characterize F77 antigen, including binding analyses with the glycolipid extract of the prostate cancer cell line PC3, microarrays with sequence-defined glycan probes, and designer arrays from the O-glycome of an antigen-positive mucin, in conjunction with mass spectrometry. [J Biol Chem] Abstract | Full Article Inhibition of RSK/YB-1 Signaling Enhances the Anti-Cancer Effect of Enzalutamide in Prostate Cancer Scientists elucidated the mechanism and role of Y-box binding protein-1 (YB-1) activation in relation to castration resistance as well as enzalutamide resistance, with a view to developing a novel therapeutic concept for castration-resistant prostate cancer treatment. [Prostate] Abstract The Aryl Hydrocarbon Receptor Is Constitutively Active in Advanced Prostate Cancer Cells qRT-PCR and western blot analysis was used to determine aryl hydrocarbon receptor mRNA and protein expression in hormone sensitive LNCaP cells as well as hormone refractory DU145, PC3 and PC3M prostate cancer cell lines. [PLoS One] Full Article Influence of Peripheral Whole-Blood MicroRNA-7 and MicroRNA-221 High Expression Levels on the Acquisition of Castration-Resistant Prostate Cancer: Evidences from In Vitro and In Vivo Studies Researchers identified a microRNA (miRNA) expression profile associated with the development of castration-resistant prostate cancer. They observed a miRNA expression profile differentially expressed between the castration-resistant PC3 cell line and the hormone-sensitive LnCaP cell line, where miR-7, miR-221, and miR-222 were upregulated in PC3. [Tumor Biol] Abstract PGE2 Modulates the Transcriptional Activity of ERRa in Prostate Stromal Cells Scientists showed that prostaglandin E2 (PGE2) affects aromatase expression by regulating estrogen receptor-related receptor a (ERRa) transcriptional activity in prostate stromal cells. [Endocrine] Abstract MicroRNA-18a Is Elevated in Prostate Cancer and Promotes Tumorigenesis through Suppressing STK4 In Vitro and In Vivo Researchers found significant upregulation of microRNA-18a in prostate cancer specimens and prostate cancer cell lines compared with the normal controls. [Oncogenesis] Full Article CLINICAL RESEARCH Gemcitabine-Oxaliplatin plus Prednisolone Is Active in Patients with Castration-Resistant Prostate Cancer for Whom Docetaxel-Based Chemotherapy Failed Patients with castration-resistant prostate cancer who failed prior docetaxel were treated with gemcitabine 1000?mg?m-2 and oxaliplatin 100?mg?m-2 intravenously every two weeks and prednisolone 5?mg orally twice daily. The primary end point was the prostate-specific antigen response rate. [Br J Cancer] Abstract Circulating Endothelial Progenitor Cells in Castration Resistant Prostate Cancer: A Randomized, Controlled, Biomarker Study Researchers investigated the effect of docetaxel and sunitinib on endothelial progenitor cells/circulating endothelial cells kinetics and clinical response in castration resistant prostate cancer patients. [PLoS One] Full Article |