LABORATORY RESEARCH Regulation of SRC Kinases by MicroRNA-3607 Located in a Frequently Deleted Locus in Prostate Cancer Scientists examined the functional significance of miR-3607 in prostate cancer cell lines and found that miR-3607 overexpression led to significantly decreased proliferation, apoptosis induction and decreased invasiveness. [Mol Cancer Ther] Abstract Androgen Receptor as a Regulator of ZEB2 Expression and Its Implications in Epithelial-to-Mesenchymal Transition in Prostate Cancer Zinc finger E-box-binding protein 2 (ZEB2) expression was found to be significantly upregulated after androgen stimulation and downregulated following androgen receptor silencing in LNCaP cells, an androgen-dependent prostate cancer cell line. [Endocr Relat Cancer] Abstract VDR Activity Is Differentially Affected by Hic-5 in Prostate Cancer and Stromal Cells Transforming growth factor-beta, which is associated with the development of tumorigenic “reactive stroma” in prostate cancer, induced VDR expression in the human WPMY-1 prostate stromal cell line. [Mol Cancer Res] Abstract Overexpression of HepaCAM Inhibits Cell Viability and Motility through Suppressing Nucleus Translocation of Androgen Receptor and ERK Signaling in Prostate Cancer HepaCAM expression was significantly down-regulated in prostate cancer tissues and undetected in prostate cancer cells. However, low HepaCAM expression was not statistically associated with clinicopathological characteristics of prostate cancer. [Prostate] Abstract Development and Characterization of an Antibody-Labeled Super-Paramagnetic Iron Oxide Contrast Agent Targeting Prostate Cancer Cells for Magnetic Resonance Imaging A muJ591:Molday ION Rhodamine-B Carboxyl complex reduced cell adhesion and cell proliferation on LNCaP cells and caused apoptosis as tested by Annexin V assay, suggesting anti-tumorigenic characteristics. [PLoS One] Full Article Tumor-Suppressive MicroRNA-218 Inhibits Cancer Cell Migration and Invasion via Targeting of LASP1 in Prostate Cancer Researchers investigated the functional significance of microRNA (miR)-218 in prostate cancer (PCa) and to identify novel miR-218-regulated cancer pathways and target genes involved in PCa oncogenesis and metastasis. [Cancer Sci] Abstract Tumor-Suppressive MicroRNA-29s Inhibit Cancer Cell Migration and Invasion via Targeting LAMC1 in Prostate Cancer Scientists investigated the functional significance of microRNA (miR)-29 in cancer cells and to identify novel miR-29s-mediated cancer pathways and target genes involved in prostate cancer oncogenesis and metastasis. [Int J Oncol] Abstract CLINICAL RESEARCH Prostatic and Dietary Omega-3 Fatty Acids and Prostate Cancer Progression during Active Surveillance Researchers hypothesized that compared to the estimated dietary omega-3 (ω-3) fatty acids intake and the ω-3 fatty acids level measured in red blood cells, the prostate tissue ω-3 fatty acids content is more strongly related to prostate cancer (PCa) progression. They present the initial observations from baseline data of a Phase II clinical trial conducted in a cohort of 48 untreated men affected with low-risk PCa, managed under active surveillance. [Cancer Prev Res] Abstract Serum Fucosylated Haptoglobin as a Novel Prognostic Biomarker Predicting High-Gleason Prostate Cancer Scientists measured the preoperative serum fucosylated haptoglobin (Fuc-Hpt) levels in 98 patients who underwent radical prostatectomy using an established lectin-antibody ELISA. Serum Fuc-Hpt levels were significantly associated with Gleason score, but not prostate-specific antigen levels. [Prostate] Abstract |