Prostate Cell News Volume 5.21 | Jun 13 2014

ID4 Inactivation Promotes De Novo Steroidogenesis and Castration Resistant Prostate Cancer
Researchers investigated the effect of loss of Inhibitor of differentiation 4 (ID4) in prostate cancer cell lines on tumorigenicity and addresses the underlying mechanism. [Mol Endocrinol] Abstract

A Novel Small Molecule Hybrid of Vorinostat and DACA Displays Anticancer Activity against Human Hormone-Refractory Metastatic Prostate Cancer through Dual Inhibition of Histone Deacetylase and Topoisomerase I
WJ35435, a new hybrid of vorinostat and DACA potently inhibited histone deacetylase activity in kinase assay and cell-based examination. WJ35435 showed better potency than vorinostat and DACA against PC-3 and DU-145, two human hormone-refractory metastatic prostate cancer cell lines, but not benign prostate cells. [Biochem Pharmacol] Abstract

miR-124 Exhibits Antiproliferative and Antiaggressive Effects on Prostate Cancer Cells through PACE4 Pathway
Scientists strived to find some key microRNAs to decrease malignancy and invasiveness of prostate cancer cells through regulating PACE4 expression. [Prostate] Full Article

Generation and Characterization of a Canine EGFP-HMGA2 Prostate Cancer In Vitro Model
Investigators established a canine CT1258-EGFP-HMGA2 prostate cancer cell line stably overexpressing High-Mobility-Group Protein A2 (HMGA2) linked to EGFP and in addition the reference cell line CT1258-EGFP expressing solely EGFP to exclude EGFP-induced effects. [PLoS One] Full Article

Transcription Factors Involved in Prostate Gland Adaptation to Androgen Deprivation
Researchers identified transcription factors that regulate gene expression after androgen deprivation by castration. [PLoS One] Full Article

Zeb1 Promotes Androgen Independence of Prostate Cancer via Induction of Stem Cell-Like Properties In Vitro Model
Investigators demonstrated elevated expression of Zeb1 in androgen-independent prostate cancer cells and prostate tumors of castrated PTEN conditional knockout mice. [Exp Biol Med] Abstract

CLINICAL RESEARCH

5α-Reductase Inhibitors and Risk of High-Grade or Lethal Prostate Cancer
Researchers aimed to determine the association between 5α-reductase inhibitors use and development of high-grade or lethal prostate cancer. [JAMA Intern Med] Abstract

A Three-Protein Biomarker Panel Assessed in Diagnostic Tissue Predicts Death from Prostate Cancer for Men with Localized Disease
Scientists evaluated whether a panel of biomarkers, associated with a range of disease outcomes in previous studies, could predict death from prostate cancer for men with localized disease. [Cancer Med] Full Article

A Functional Variant in NKX3.1 Associated with Prostate Cancer Risk in the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
Results indicated that variation in NKX3.1 expression combined with selenium or vitamin E treatment modified the risk of prostate cancer. Genetic background may modulate the effects of antioxidant supplementation thought to act as chemoprevention agents. [Cancer Prev Res] Abstract

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George Washington Cancer Institute Contributes to Clinical Care Guidelines for the Growing Number of Prostate Cancer Survivors
In response to the increasing need to support primary care clinicians who care for prostate cancer survivors, the American Cancer Society (ACS), with support from the George Washington Cancer Institute and a panel of experts, has published the ACS Prostate Cancer Survivorship Care Guidelines. [George Washington University] Press Release

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