LABORATORY RESEARCH Genetic Ablation of Metadherin Inhibits Autochthonous Prostate Cancer Progression and Metastasis Researchers demonstrate that direct silencing of metadherin (MTDH) in prostate cancer cells decreased proliferation in vitro and tumor growth in vivo, supporting an epithelial cell-intrinsic role of MTDH in prostate cancer. [Cancer Res] Abstract Androgen-Regulated microRNA-135a Decreases Prostate Cancer Cell Migration and Invasion Through Downregulating ROCK1 and ROCK2 Using xenograft experiments in chick embryos and adult male mice, researchers showed that miR-135a overexpression decreased in vivo invasion abilities of prostate PC-3 cells. [Oncogene] Abstract Ion Channel TRPM8 Promotes Hypoxic Growth of Prostate Cancer Cells via an O2-Independent and RACK1-Mediated Mechanism of HIF-1α Stabilization Scientists identified a mechanistic insight on how TRPM8 promotes the hypoxic growth adaptation of cancer cells via its promotion of RACK1-mediated stabilization of HIF-1α and a potential therapeutic strategy for prostate cancer by targeting TRPM8. [J Pathol] Abstract Castration-Induced Bone Loss Triggers Growth of Disseminated Prostate Cancer Cells in Bone Researchers used an in vivo model mimicking androgen ablation to establish the effects of this intervention on disseminated prostate cancer cells in bone. [Endocr Relat Cancer] Abstract Prostate Cancer Cell Malignancy via Modulation of HIF-1α Pathway with Isoflurane and Propofol Alone and in Combination The prostate cancer cell line PC3 was exposed to commonly used anesthetic isoflurane and propofol. Malignant potential was assessed through evaluation of expression level of hypoxia-inducible factor-1α (HIF-1α) and its downstream effectors, cell proliferation and migration as well as development of chemoresistance. [Br J Cancer] Abstract Altered Endosome Biogenesis in Prostate Cancer has Biomarker Potential A panel of endosomal markers was evaluated by investigators in prostate cancer and non-malignant cells and a significant increase in gene and protein expression was found for early, but not late endosomal proteins. [Mol Cancer Res] Abstract Inhibition of Hsp90 Augments Docetaxel Therapy in Castrate Resistant Prostate Cancer Scientists report that a second generation heat shock protein 90 (Hsp90) inhibitor, NVP-AUY922, inhibited cell growth and significantly induced cell death in MYC-CaP/CR and Pten-CaP/cE2 cell lines. [PLoS One] Full Article Effect of Lycopene Isolated from Chlorella marina on Proliferation and Apoptosis in Human Prostate Cancer Cell Line PC-3 Scientists assessed the anti-proliferative and apoptotic effect of lycopene from a new source and compared the activity with available trans-lycopene by using androgen-independent human prostate cancer cell lines. [Tumour Biol] Abstract Knockdown of Ubiquitin Associated Protein 2-Like Inhibits the Growth and Migration of Prostate Cancer Cells Investigators found that ubiquitin associated protein 2-like (UBAP2L) was expressed in a number of prostate carcinoma cell lines. They report that UBAP2L may play a role in prostate cancer growth and metastasis, and knockdown of UBAP2L by RNA interference may serve as a potential therapeutic approach for prostate cancer. [Oncol Rep] Abstract CLINICAL RESEARCH Docetaxel Rechallenge in Patients with Metastatic Castration-Resistant Prostate Cancer Investigators evaluated the benefit of docetaxel rechallenge in patients with metastatic castration-resistant prostate cancer relapsing after an initial good response to first-line doxetaxel. [BJU Int] Abstract Zoledronic Acid Improves Clinical Outcomes in Patients with Bone Metastatic Hormone-Naïve Prostate Cancer in a Multicenter Clinical Trial Scientists assessed whether zoledronic acid added to the effect of combined androgen blockade in patients with hormone-naive bone metastatic prostate cancer. [Anticancer Res] Abstract |