Prostate Cell News Volume 5.36 | Sep 26 2014

MicroRNA Expression Profile of Primary Prostate Cancer Stem Cells as a Source of Biomarkers and Therapeutic Targets
Investigators discovered concordance between the microRNA expression profiles of unfractionated epithelial cells from castration-resistant prostate cancer, human embryonic stem cells (SCs), and prostate epithelial SCs (both benign and malignant). [Eur Urol] Abstract

Plk1 Inhibition Enhances the Efficacy of Androgen Signaling Blockade in Castration-Resistant Prostate Cancer
Scientists show that oxidative stress activates both the PI3K/AKT/mTOR pathway and androgen receptor (AR) signaling in a polo-like kinase 1 (Plk1)-dependent manner in prostate cells. Inhibition of the PI3K/AKT/mTOR pathway prevented oxidative stress-induced activation of AR signaling. [Cancer Res] Abstract

UAP1 Is Overexpressed in Prostate Cancer and Is Protective against Inhibitors of N-Linked Glycosylation
Investigators analyzed 3261 prostate cancers on a tissue microarray and found that UDP-N-acetylglucosamine pyrophosphorylase 1 (UAP1) staining correlates negatively with Gleason score and positively with high androgen receptor expression. [Oncogene] Abstract

Role of the Phospholipase A₂ Receptor in Liposome Drug Delivery in Prostate Cancer Cells
The authors examined phospholipase A₂ receptor (PLA2R1) expression in primary prostate cells and human prostate cancer cells, and they determined the effect of PLA2R1 knockdown on cytotoxicity induced by free or liposome-encapsulated chemotherapeutics. [Mol Pharm] Abstract

INPP4B Suppresses Prostate Cancer Cell Invasion
The authors demonstrate that de novo expression of INPP4B in highly invasive human prostate carcinoma PC-3 cells suppresses their invasion both in vitro and in vivo. Using global gene expression analysis, they found that INPP4B regulates a number of genes associated with cell adhesion, the extracellular matrix, and the cytoskeleton. [Cell Commun Signal] Abstract | Full Article

A Role for STEAP2 in Prostate Cancer Progression
Quantitative analysis of six transmembrane epithelial antigen of the prostate (STEAP) 1 and 2 gene expression were statistically significantly associated with the metastatic cell lines DU145 and PC3 as compared to the normal prostate epithelial cell line, PNT2. [Clin Exp Metastasis] Abstract

In Vitro Evaluation of Novel N-Acetylalaninate Prodrugs that Selectively Induce Apoptosis in Prostate Cancer Cells
To evaluate chiral ester prodrugs, researchers monitored cellular glutathione depletion, cellular protein carbonyl levels (an oxidative stress biomarker) and cell viability in tumorigenic and nontumorigenic prostate cancer cell lines. [BMC Cancer] Full Article

CLINICAL RESEARCH

Abiraterone Acetate for Patients with Metastatic Castration-Resistant Prostate Cancer Progressing after Chemotherapy: Final Analysis of a Multicenter, Open-Label, Early-Access Protocol Trial
Researchers present the final analysis of an early-access protocol trial that was initiated after completion of COU-AA-301 to enable worldwide preapproval access to abiraterone acetate in patients with metastatic castration-resistant prostate cancer progressing after chemotherapy. [Lancet Oncol] Abstract

A Phase II Trial of a Combination Herbal Supplement for Men with Biochemically Recurrent Prostate Cancer
Men previously treated for prostate cancer with surgery, radiation or both with rising PSA but no radiographic metastases were treated with three capsules of Prostate Health Cocktail daily; the primary end point was 50% PSA decline. [Prostate Cancer Prostatic Dis] Abstract

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UR Awarded $18 Million for Cancer Control Studies; Grant Among Largest in Decade
As a result of longstanding research strength, the Cancer Control & Survivorship program at University of Rochester (UR) Medicine’s Wilmot Cancer Institute has been selected to receive an $18.6 million, five-year grant for a leadership role in a nationwide clinical research network to investigate cancer-related side effects. [University of Rochester] Press Release

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NEW Research Assistant – Clinical Prostate Cancer Research Group (Garvan Institute of Medical Research)

Postdoctoral Fellows and Graduate Student Positions (Vancouver Prostate Centre)

Postdoctoral Scientist – Prostate Oncobiology (Cancer Research UK – Manchester Institute)

Postdoctoral Position – Prostate Cancer Research (Umeå University)

Postdoctoral Positions – Prostate Metastasis Evolution (Cold Spring Harbor Laboratory)

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Scientist – Prostate Cell Research (STEMCELL Technologies Inc.)

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