LABORATORY RESEARCH Nuclear iASPP May Facilitate Prostate Cancer Progression Researchers identified inhibitor of apoptosis-stimulating protein of p53 (iASPP), a common cellular regulator of p53 and p63, as an important player of prostate cancer progression. [Cell Death Dis] Full Article ERG Oncoprotein Inhibits ANXA2 Expression and Function in Prostate Cancer Genomic analysis of ERG siRNA-treated prostate cells harboring the endogenous TMPRSS2-ERG fusion revealed an inverse relationship between ERG and Annexin A2 (ANXA2) expression at both the RNA and protein level. ERG overexpression disrupted ANXA2 mediated cell polarity and promoted epithelial mesenchymal transition by inhibiting CDC42 and RHOA, and by activating cofilin. [Mol Cancer Res] Abstract HIF-1alpha Regulates mTOR Signaling and Viability of Prostate Cancer Stem Cells To further analyze the consequences of hypoxic upregulation on stem cell proliferation and hypoxia-inducible factor 1alpha signaling, cancer stem cells subpopulations from murine TRAMP-C1 cells as well as from a human prostate cancer cell line were isolated and characterized. [Mol Cancer Res] Abstract N-3 Polyunsaturated Fatty Acids Inhibit IFN-γ-Induced IL-18 Binding Protein Production by Prostate Cancer Cells Investigators demonstrate that n-3 polyunsaturated fatty acids treatment significantly reduced interferon (IFN)-γ-induced IL-18BP production by DU-145 and PC-3 prostate cancer cells by inhibiting IL-18BP mRNA expression and was associated with a reduction in IFN-γ receptor expression. [Cancer Immunol Immunother] Abstract Epithelial-Mesenchymal Transition in Prostate Cancer Is Associated with Quantifiable Changes in Nuclear Structure Researchers determined whether epithelial and mesenchymal prostate cancer cells have different nuclear morphology. Murine tibia injections of epithelial PC3 and mesenchymal PC3 prostate cancer cells were processed and stained with H&E. [Prostate] Abstract Nobiletin Suppresses Cell Viability through AKT Pathways in PC-3 and DU-145 Prostate Cancer Cells Scientists investigated the effects of nobiletin in prostate cancer cell lines PC-3 and DU-145. Data showed that nobiletin decreased cell viability in both prostate cell lines, with a greater reduction in viability in PC-3 cells. [BMC Pharmacol Toxicol] Full Article CLINICAL RESEARCH Efficacy and Safety of Radium-223 Dichloride in Patients with Castration-Resistant Prostate Cancer and Symptomatic Bone Metastases, with or without Previous Docetaxel Use: A Prespecified Subgroup Analysis from the Randomized, Double-Blind, Phase III ALSYMPCA Trial Researchers analyzed a prespecified subgroup from ALSYMPCA to assess the effect of previous docetaxel use on the efficacy and safety of radium-223. [Lancet Oncol] Abstract 99mTc-Labeled Small-Molecule Inhibitors of Prostate-Specific Membrane Antigen: Pharmacokinetics and Biodistribution Studies in Healthy Subjects and Patients with Metastatic Prostate Cancer Under an exploratory investigational new drug, using a cross-over design, the authors compared the pharmacokinetics, biodistribution, and tumor uptake of 99mTc-MIP-1404 and 99mTc-MIP-1405 in six healthy men and six men with radiographic evidence of metastatic prostate cancer. [J Nucl Med] Abstract |