Prostate Cell News Volume 5.44 | Nov 21 2014

AGE Modified Basement Membrane Cooperates with Endo180 to Promote Epithelial Cell Invasiveness and Decrease Prostate Cancer Survival
Scientists hypothesized that the structural alterations in the basal lamina associated with age can induce mechanotransduction pathways in prostate epithelial cells to promote invasiveness and cancer progression.
[J Pathol] Abstract

MicroRNA-940 Suppresses Prostate Cancer Migration and Invasion by Regulating MIEN1
A novel microRNA (miRNA), hsa-miR-940 (miR-940), identified and validated to be highly expressed in immortalized normal cells compared to cancer cells, is a regulator of migration and invasion enhancer 1 (MIEN1). Analysis of human prostate tumors and their matched normal tissues confirmed that miR-940 is highly expressed in the normal tissues compared to its low to negligible expression in the tumors. [Mol Cancer] Abstract | Full Article

Combination Simvastatin and Metformin Induces G1-Phase Cell Cycle Arrest and Ripk1- and Ripk3-Dependent Necrosis in C4-2B Osseous Metastatic Castration-Resistant Prostate Cancer Cells
Treatment of C4-2B cells with combination 4μM simvastatin and 2mM metformin led to significant G1-phase cell cycle arrest and decrease in the percentage of DNA-replicating cells in the S-phase by 24 hours; arrest was sustained throughout the 96-hour treatment. [Cell Death Dis] Full Article

Apigenin Manipulates the Ubiquitin-Proteasome System to Rescue Estrogen Receptor-β from Degradation and Induce Apoptosis in Prostate Cancer Cells
Researchers investigated apigenin, a dietary flavonoid with proteasome-inhibitory activity, against FDA-approved anticancer proteasome inhibitor bortezomib in context to its effects on the tumor suppressor estrogen receptor-beta in prostate cancer cells. [Eur J Nutr] Abstract

The Cytotoxic and Pro-Apoptotic Activities of the Novel Fluoropyrimidine F10 towards Prostate Cancer Cells Are Enhanced by Zn²⁺-Chelation and Inhibiting the Serine Protease Omi/HtrA2
To test the hypothesis that the pro-apoptotic effects of F10 could be enhanced by modulating intracellular Zn²⁺ scientists investigated cell-permeable and cell-impermeable Zn²⁺ chelators and exogenous Zn²⁺ and evaluated cell viability and apoptosis in cellular models of castration-resistant prostate cancer. [Prostate] Abstract

Differential Effects of Tissue Culture Coating Substrates on Prostate Cancer Cell Adherence, Morphology and Behavior
To improve the adherence of LNCaP cells to the culture surface, researchers compared different coating reagents and culturing conditions and analyzed their impact on cell proliferation, adhesion, morphology, mobility and gene expression using real-time technologies. [PLoS One] Full Article

Comprehensive Study of Gene and MicroRNA Expression Related to Epithelial-Mesenchymal Transition in Prostate Cancer
Scientists analyzed gene and microRNA expression involved in epithelial-mesenchymal transition in localized prostate cancer and metastatic prostate cancer cell lines and correlate with clinicopathological findings. They studied 51 fresh frozen tissue samples from patients with localized prostate cancer treated by radical prostatectomy and three metastatic prostate cancer cell lines. [PLoS One] Full Article

NSK-01105 Inhibits Proliferation and Induces Apoptosis of Prostate Cancer Cells by Blocking the Raf/MEK/ERK and PI3K/Akt/mTOR Signal Pathways
Researchers investigated the antitumor activities of NSK-01105, a novel sorafenib derivative, in in vitro and in vivo models, and explored the potential mechanisms. [Tumor Biol] Abstract

Antiproliferative Activity of Aqueous Leaf Extract of Annona muricata L. on the Prostate, BPH-1 Cells, and Some Target Genes
Annona muricata L. has been reported to possess antitumor and antiproliferative properties. Scientists determined the effect of A. muricata on human BPH-1 cells and prostate organ. [Integr Cancer Ther] Abstract

CLINICAL RESEARCH

A Phase I Study of TRC105 Anti-CD105 (Endoglin) Antibody in Metastatic Castration-Resistant Prostate Cancer
Scientists evaluated the safety, pharmacokinetics, and pharmacodynamics of TRC105 in patients with metastatic castration-resistant prostate cancer. [BJU Int] Abstract

Evaluation of PSF1 as a Prognostic Biomarker for Prostate Cancer
Scientists evaluated the relationship between partner of SLD5 1 (PSF1) expression and the clinical features of prostate cancer. They show that the PSF1 expression correlated significantly with PSA values at diagnosis, with tumor grade, and with clinical stage. [Prostate Cancer Prostatic Dis] Abstract

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SOTIO Initiates US Part of VIABLE, a Global Phase III Clinical Trial for Prostate Cancer Immunotherapy Treatment Using DCVAC/PCa
SOTIO announced that the first US patient has been enrolled in its VIABLE study, the global Phase III clinical trial for DCVAC/PCa, an active cellular immunotherapy treatment for prostate cancer patients. [SOTIO, LLC] Press Release

Tokai Pharmaceuticals Presents Updated Interim Galeterone ARMOR2 Data Showing Activity in Patients with Castration-Resistant Prostate Cancer (CRPC) including Those Showing a Variant Form of Prostate Cancer Resistant to Hormone Therapy
Tokai Pharmaceuticals, Inc. announced updated interim results from its ongoing ARMOR2 Phase II clinical trial of galeterone in CRPC patients. [Tokai Pharmaceuticals, Inc.] Press Release

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

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NEW Associate Professor – Physiology (University of Bergen)

Postdoctoral Position – Prostate Cancer (Roswell Park Cancer Institute)

Postdoctoral Position – Prostate Cancer and Prostatic Diseases (Louisiana State University)

Postdoctoral Associate – Biomarkers Associated with Prostate Cancer (Duke Molecular Physiology Institute)

Head of Cellular and Molecular Therapies Laboratory (NHS Blood & Transplant)

Postdoctoral Fellow – Metabolomics and Prostate Cancer (University of Maryland)

Postdoctoral Fellow – Role of Deregulated PTEN/FOXO1 Pathway in Prostate Cancer (Mayo Clinic)

Postdoctoral Fellow – Oncology (Johnson & Johnson Pharmaceutical Research & Development)

Postdoctoral Fellow – Prognostic Biomarkers for Prostate Cancer (McGill University)

Physician Scientist – Prostate Cancer Genomics (University of Chicago)

Tenure Track Position – Cancer Biology (Wake Forest Baptist Medical Center)

Scientist – Prostate Cell Research (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

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