Prostate Cell News Volume 6.22 | Jun 19 2015

A MicroRNA Code for Prostate Cancer Metastasis
Investigators showed that loss of miR-15 and miR-16 in cooperation with increased miR-21 expression promote prostate cancer spreading and bone lesions. This combination of microRNAs endows bone-metastatic potential to prostate cancer cells. [Oncogene] Full Article

CRISPR/Cas9-Mediated Gene Knockout of NANOG and NANOGP8 Decreases the Malignant Potential of Prostate Cancer Cells
Investigators established NANOG and NANOGP8-knockout DU145 prostate cancer cell lines using the CRISPR/Cas9 system. Knockouts of NANOG and NANOGP8 significantly attenuated malignant potential, including sphere formation, anchorage-independent growth, migration capability, and drug resistance, compared to parental DU145 cells. [Oncotarget] Full Article

Hypoxia Induces Triglycerides Accumulation in Prostate Cancer Cells and Extracellular Vesicles Supporting Growth and Invasiveness following Reoxygenation
Researchers report that under hypoxia, human prostate cancer cells, and extracellular vesicles released by these cells, are significantly enriched in triglycerides due to the activation of lipogenesis-related enzymes and signaling molecules. [Oncotarget] Full Article

GLIPR1-ΔTM Synergizes with Docetaxel in Cell Death and Suppresses Resistance to Docetaxel in Prostate Cancer Cells
Scientists evaluated the hypothesis that the combination treatment with docetaxel and GLIPR1-ΔTM will synergistically induce greater cell death and inhibit the emergence of resistance and development of metastatic potential in prostate cancer cells. [Mol Cancer] Abstract | Full Article

Development of Novel Radio-Chemotherapy Approaches Targeting Prostate Tumor Progenitor Cells Using Nanohybrids
Researchers describe the synthesis of biocompatible, catechin-loaded and gelatin-conjugated carbon nanotubes with anticancer properties and demonstrated their potential for the eradication of prostate cancer stem cells in combination with X-ray irradiation. [Int J Cancer] Abstract

Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts
Scientists investigated the ability of Pim kinases to promote metastatic growth of prostate cancer cells in two xenograft models for human prostate cancer. They also evaluated the efficacy of Pim-selective inhibitors to antagonize these effects. [PLoS One] Full Article

Oncolytic Virus Carrying shRNA Targeting SATB1 Inhibits Prostate Cancer Growth and Metastasis
The authors constructed ZD55-SATB1, an oncolytic adenovirus ZD55 carrying shRNA targeting SATB1, and investigated its effects on the inhibition of prostate cancer growth and metastasis. ZD55-SATB1 was constructed and used to infect human prostate cancer cell lines DU145 and LNCaP. [Tumor Biol] Abstract

Metformin Induces ER Stress-Dependent Apoptosis through miR-708-5p/NNAT Pathway in Prostate Cancer
Scientists identified miR-708-5p as a novel target of metformin in prostate cancer cells. Metformin promotes increased expression of miR-708-5p, leading to suppression of endoplasmic reticulum (ER) membrane protein neuronatin expression and subsequently induces apoptosis of prostate cancer cells through the ER stress pathway. [Oncogenesis] Full Article

CLINICAL RESEARCH

A Randomized Non-Comparative Phase II Trial of Cixutumumab (IMC-A12) or Ramucirumab (IMC-1121B) plus Mitoxantrone and Prednisone in Men with Metastatic Docetaxel-Pretreated Castration-Resistant Prostate Cancer
A non-comparative randomized Phase II study evaluated cixutumumab or ramucirumab plus mitoxantrone and prednisone in metastatic castration-resistant prostate cancer. [Eur J Cancer] Abstract

Androgen Receptor Splice Variant 7 and Efficacy of Taxane Chemotherapy in Patients with Metastatic Castration-Resistant Prostate Cancer
Scientists investigated whether AR-V7–positive patients would retain sensitivity to taxane chemotherapy and whether AR-V7 status would have a differential impact on taxane-treated men compared with enzalutamide- or abiraterone-treated men. [JAMA Oncol] Full Article | Press Release

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Anonymous Donor Gives $20 Million for Cancer Research at Wake Forest Baptist
Wake Forest Baptist Medical Center has received $20 million to study the effects of muscadine grape extract on prostate and breast cancers. The gift by a donor who wishes to remain anonymous is the largest ever received by the Medical Center. [Wake Forest Baptist Medical Center] Press Release

Ludwig Cancer Research Expands Presence in Lausanne
Ludwig Cancer Research announced that it is opening a new branch in Lausanne, Switzerland. The branch will be focused primarily on applied cancer immunology and the design of novel molecular and cell-based immunotherapies. [Ludwig Cancer Research] Press Release

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Research Technician (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellows – Molecular Mechanisms of Prostate Cancer Progression and Therapeutic Resistance (Tulane University School of Medicine)

Postdoctoral Fellowship – Molecular Mechanisms and Translational Investigations of Advanced Prostate Cancer (Cleveland Clinic Lerner Research Institute)

Research Scientists – Tissue Biorepository and Data Resource for Prostate Cancer (NYU Langone Medical Center)

Research Assistant Professor or Instructor – Prostate Cancer (Thomas Jefferson University)

Postdoctoral Positions – Cancer, Stem Cell, and Developmental Biology (Columbia University Medical Center)

Senior Postdoctoral Position – Prostate Cancer (Institut Paoli Calmettes)

Postdoctoral Positions – Molecular Cancer Biology (University of Pennsylvania)

Postdoctoral Technician – Prostate/Breast Cancer (Baylor College of Medicine)

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