Prostate Cell News Volume 6.25 | Jul 10 2015

Heat-Shock Factor 2 Is a Suppressor of Prostate Cancer Invasion
Scientists report that heat-shock factor (HSF)2 suppresses tumor invasion of prostate cancer. In three-dimensional organotypic cultures and the in vivo xenograft chorioallantoic membrane model, HSF2 knockdown perturbs organoid differentiation and promotes invasiveness. [Oncogene] Full Article

Discovery of ODM-201, a New-Generation Androgen Receptor Inhibitor Targeting Resistance Mechanisms to Androgen Signaling-Directed Prostate Cancer Therapies
ODM-201 reduced the growth of androgen receptor-overexpressing VCaP prostate cancer cells both in vitro and in a castration-resistant VCaP xenograft model. [Sci Rep] Full Article

Proteomic Comparison and MRM Based Comparative Analysis of Metabolites Reveals Metabolic Shift in Human Prostate Cancer Cell Lines
Researchers compared the proteomes of three pairs of androgen-sensitive and androgen-independent PCa cell lines, namely PC3-androgen receptor⁺/PC3, 22Rv1/Du145 and LNCaP/C42B using an iTRAQ labeling approach. [J Proteome Res] Abstract

Plakophilin 1-Deficient Cells Upregulate SPOCK1: Implications for Prostate Cancer Progression
Plakophilin (PKP) 1 is frequently downregulated in prostate cancer and therefore may play a tumor-suppressive role. Investigators stably knocked down PKP1 in the non-neoplastic, prostatic BPH-1 cell line. [Tumor Biol] Abstract

Changes in Estrogen Receptor ERβ (ESR2) Expression without Changes in the Estradiol Levels in the Prostate of Aging Rats
Despite the relationship between reductions in ERβ and abnormal growth of the gland, little is known about the age-dependent variation of this receptor. Researchers investigated ERβ expression in the prostatic lobes of aging Wistar rats. [PLoS One] Full Article

Disabled Homolog 2 Is Required for Migration and Invasion of Prostate Cancer Cells
Disabled homolog 2 (DAB2) expression was upregulated along with human prostate cancer (PCa) progression. DAB2 overexpression or knockdown effects in LNCaP and PC3 cell lines were verified to address the biological functions of DAB2 in PCa progression and metastasis. [Front Med] Abstract

CLINICAL RESEARCH

Efficacy and Safety of Abiraterone Acetate in Elderly (≥75 Years) Chemotherapy-Naïve Patients with Metastatic Castration-Resistant Prostate Cancer
The authors investigated the safety and efficacy of abiraterone acetate in elderly and younger patient subgroups at the prespecified interim analysis for the COU-AA-302 trial.[J Urol] Abstract

“Natural Course” of Disease in Patients with Metastatic Castrate-Resistant Prostate Cancer: Survival and Prognostic Factors without Life-Prolonging Treatment
Researchers determined the survival and prognostic factors in unselected patients with metastatic castrate-resistant prostate cancer (mCRPC), who never received life-prolonging treatment. [Scand J Urol] Abstract

OHSU Sets Fundraising Record by Meeting $1 Billion Challenge from Nike Co-Founder and Wife
Oregon Health & Science University (OHSU) announced it met Nike co-founder Phil Knight and his wife Penny’s $1 billion challenge by raising $500 million in less than two years to earn the Knights’ matching gift and set a fundraising record. [Oregon Health & Science University] Press Release

From our sponsor:
Learn about mucociliary differentiation of primary bronchial epithelial cells. Watch the video.

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

Visit our events page to see a complete list of events in the prostate cell community.

Assistant Professor- Urology (University of California, Los Angeles)

Postdoctoral Fellow- Oncology (Oregon Health & Science University)

Research Technician (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellows – Molecular Mechanisms of Prostate Cancer Progression and Therapeutic Resistance (Tulane University School of Medicine)

Postdoctoral Fellowship – Molecular Mechanisms and Translational Investigations of Advanced Prostate Cancer (Cleveland Clinic Lerner Research Institute)

Research Scientists – Tissue Biorepository and Data Resource for Prostate Cancer (NYU Langone Medical Center)

Postdoctoral Positions – Cancer, Stem Cell, and Developmental Biology (Columbia University Medical Center)

Senior Postdoctoral Position – Prostate Cancer (Institut Paoli Calmettes)

Postdoctoral Technician – Prostate/Breast Cancer (Baylor College of Medicine)

Recruit Top Talent: Reach more than 60,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.