Prostate Cell News Volume 6.26 | Jul 17 2015

Effect of Extracellular Calcium on Regucalcin Expression and Cell Viability in Neoplastic and Non-Neoplastic Human Prostate Cells
Researchers aimed to unveil the role of extracellular calcium (Ca²⁺₀) on regucalcin (RGN) expression and viability of non-neoplastic and neoplastic prostate cell lines. They demonstrated that Ca²⁺₀ up-regulates RGN expression in both cell lines, but important differences were found between cells for dose- and time-responses to Ca²⁺₀ treatment. [Biochim Biophys Acta] Abstract

Regulation of Human UDP-Glucuronosyltransferase 2B15 and 2B17 by miR-376c in Prostate Cancer Cell Lines
Scientists identified a putative miR-376c target site in the 3′-untranslated regions of both UGT2B15 and UGT2B17 mRNAs. In accord with the possibility that this miRNA negatively regulates UGT2B15 and UGT2B17 expression, there is an inverse correlation in the levels of miR-376c and UGT2B15/UGT2B17 mRNAs in prostate cancer cell lines versus normal prostate tissue. [J Pharmacol Exp Ther] Abstract

Characterization of Autoimmune Inflammation Induced Prostate Stem Cell Expansion
Ovalbumin specific CD8⁺ T cells were intravenously delivered to intact and castrated prostate ovalbumin expressing transgenic-3 mice to induce inflammation. Lin (CD45/CD31)⁻Sca1⁺CD49f⁺ cells (LSC) and progenitor cells within LSC were determined by flow cytometry. Sorted LSC were subjected to a prostate sphere forming assay to evaluate prostate stem cell clonal propagation, proliferation, immediate differentiation, and self-renewal ability. [Prostate] Full Article

Repurposing of Phentolamine as a Potential Anticancer Agent against Human Castration-Resistant Prostate Cancer: A Central Role on Microtubule Stabilization and Mitochondrial Apoptosis Pathway
Phentolamine induced anti-proliferative effect in PC-3 and DU-145, two castration-resistant prostate cancer cell lines, and P-glycoprotein overexpressing cells. This effect was not significantly reduced in paclitaxel-resistant cells. [Prostate] Abstract

Poly (Archive) Binding Protein Cytoplasmic 1 Is a Novel Co-Regulator of the Androgen Receptor
Knockdown of poly (Archive) binding protein cytoplasmic 1 decreased nuclear androgen receptor (AR) protein levels and inhibited androgen activation of the AR target PSA in LNCaP and C4-2 cells. [PLoS One] Full Article

P2Y2 Receptor and EGFR Cooperate to Promote Prostate Cancer Cell Invasion via ERK1/2 Pathway
Investigators found that extracellular ATP/UTP induced activation of EGFR and ERK1/2. Knockdown of IL-8 inhibited ATP-mediated invasion and migration of prostate cancer cells. [PLoS One] Full Article

Effects of MicroRNA-221/222 on Cell Proliferation and Apoptosis in Prostate Cancer Cells
Researchers investigated the role of miR-221/222 in cell proliferation and apoptosis in human prostate cancer cells, and examine the effects of miR-221/222 on caspase-10 expression. [Gene] Abstract

CLINICAL RESEARCH

The Incidence and Relative Risk of Cardiovascular Toxicity in Patients Treated with New Hormonal Agents for Castration-Resistant Prostate Cancer
New hormonal agents are available for treating metastatic castration-resistant prostate cancer (mCRPC). The authors aimed to define the incidence and relative risk of cardiovascular events in mCRPC patients treated with these agents. [Eur J Cancer] Abstract

A Randomized, Double-Blind, Placebo-Controlled Study of the Effects of Pomegranate Extract on Rising PSA Levels in Men following Primary Therapy for Prostate Cancer
The authors compared the effects of pomegranate juice on PSA doubling times in subjects with rising PSA levels after primary therapy for prostate cancer. [Prostate Cancer Prostatic Dis] Abstract

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apceth and University of Cologne to Join Forces on Combination Cellular Immunotherapies for Cancer
apceth announced a broad partnership with the Center for Molecular Medicine Cologne, University of Cologne, to combine technologies and expertise, on the development of immunotherapies for solid tumors and hematological malignancies. [apceth GmbH & Co. KG] Press Release

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NEW Postdoctoral Positions – Cancer Research (Rutgers University)

Postdoctoral Position – Functional Cancer Genomics (Institute of Oncology Research)

Assistant Professor- Urology (University of California, Los Angeles)

Postdoctoral Fellow- Oncology (Oregon Health & Science University)

Research Technician (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellows – Molecular Mechanisms of Prostate Cancer Progression and Therapeutic Resistance (Tulane University School of Medicine)

Postdoctoral Fellowship – Molecular Mechanisms and Translational Investigations of Advanced Prostate Cancer (Cleveland Clinic Lerner Research Institute)

Research Scientists – Tissue Biorepository and Data Resource for Prostate Cancer (NYU Langone Medical Center)

Postdoctoral Technician – Prostate/Breast Cancer (Baylor College of Medicine)

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