LABORATORY RESEARCH Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade Scientists showed that p62 is phosphorylated via a cascade that includes MEK3/6 and p38δ and is driven by the PB1-containing kinase MEKK3. Genetic inactivation of MEKK3 or p38δ mimics that of p62 in that it leads to inhibited growth of PTEN-deficient prostate organoids. [Cell Rep] Full Article | Graphical Abstract | Press Release Integrated Proteomic and Glycoproteomic Analyses of Prostate Cancer Cells Reveals Glycoprotein Alteration in Protein Abundance and Glycosylation LNCaP and PC3 are prostate cancer cell lines that have been used as models for androgen-dependent and androgen-independent cell lines. Researchers report the analysis between these two prostate cancer cell lines using integrated global proteomics and glycoproteomics. [Mol Cell Proteomics] Abstract | Full Article STIM1 Accelerates Cell Senescence in a Remodeled Microenvironment but Enhances the Epithelial-to-Mesenchymal Transition in Prostate Cancer Researchers report an unexpected dual function of store-operated Ca2+ entry in prostate cancer progression by revealing a decrease in the expression of stromal interaction molecule 1 (STIM1) in human hyperplasia and tumor tissues of high histological grade and by demonstrating that STIM1 and ORAI1 inhibit cell growth by arresting the G0/G1 phase and enhancing cell senescence in human prostate cancer cells. [Sci Rep] Full Article Syndecan-1 Up-Regulates MicroRNA-331-3p and Mediates Epithelial-to-Mesenchymal Transition in Prostate Cancer Investigators identified neuropilin 2 and nucleus accumbens-associated protein 1 as putative target molecules in silico, as they were closely associated with the expression of microRNA-331-3p and TGF-β/Smad 4 signals. [Mol Carcinog] Abstract ErbB-2 Signaling Plays a Critical Role in Regulating Androgen-Sensitive and Castration-Resistant Androgen Receptor-Positive Prostate Cancer Cells Researchers determined the role of human epidermal growth factor receptor 2 (ErbB-2) in prostate cancer (PCa) progression and survival under steroid-reduced conditions using two independent PCa cell progression models. [Cell Signal] Abstract Two Splice Variants of Y Chromosome-Located Lysine-Specific Demethylase 5D Have Distinct Function in Prostate Cancer Cell Line (DU-145) Investigators detected two novel splice variants of lysine-specific demethylase 5D with lengths of 2650bp and 2400bp that correspond to the 100 and 80 kDa proteins in the human prostate cancer cell line, DU-145. [J Proteome Res] Abstract | Graphical Abstract Paucity of PD-L1 Expression in Prostate Cancer: Innate and Adaptive Immune Resistance Human prostate cancer cell lines were evaluated for programmed death ligand-1 (PD-L1) expression and loss of phosphatase and tensin homolog (PTEN) by flow cytometry and western blotting, respectively. Immunohistochemical (IHC) staining for PTEN was correlated with PD-L1 IHC using a series of resected human prostate cancer samples. [Prostate Cancer Prostatic Dis] Abstract CLINICAL RESEARCH Association between Very Small Tumor Size and Increased Cancer-Specific Mortality following Radical Prostatectomy in Node-Positive Prostate Cancer Investigators aimed to determine whether very small prostate cancers present in patients who also have lymph node metastases represent a particularly aggressive disease variant compared to larger node-positive tumors. [BJU Int] Abstract Urethra-Sparing High-Intensity Focused Ultrasound for Localized Prostate Cancer: Functional and Oncological Outcomes Patients with negative findings in the urethra and the anterior urethral zone using transrectal ultrasound-guided targeted biopsies, and magnetic resonance imaging, received urethra-sparing or whole-gland high-intensity focused ultrasound as the primary therapy for localized prostate cancer without transurethral resection of the prostate. [Int J Urol] Abstract |