LABORATORY RESEARCH LncRNA HOTAIR Enhances the Androgen-Receptor-Mediated Transcriptional Program and Drives Castration-Resistant Prostate Cancer Scientists report HOTAIR as an androgen-repressed lncRNA, and, as such, it is markedly upregulated following androgen deprivation therapies and in castration-resistant prostate cancer. [Cell Rep] Full Article | Graphical Abstract Targeting of Cytosolic Phospholipase A2α Impedes Cell Cycle Re-Entry of Quiescent Prostate Cancer Cells Investigators determined the role of cytosolic phospholipase A2α (cPLA2α) in cell cycle re-entry of quiescent prostate cancer cells. When PC-3 and LNCaP cells were rendered to a quiescent state, the active form of cPLA2α with a phosphorylation at Ser505 was lower compared to their proliferating state. [Oncotarget] Full Article Application of Mitochondrial Pyruvate Carrier Blocker UK5099 Creates Metabolic Reprogram and Greater Stem-Like Properties in LnCap Prostate Cancer Cells In Vitro Researchers investigated the relationship between blocking mitochondrial pyruvate carrier with UK5099 and the metabolic alteration as well as stemness phenotype of prostatic cancer cells. [Oncotarget] Full Article AMBRA1 and SQSTM1 Expression Pattern in Prostate Cancer The authors demonstrated an increased expression of AMBRA1 and the autophagic protein sequestosome-1 (SQSTM1), which were also associated with an accumulation of LC3II in prostate cancer but not in benign lesion. [Apoptosis] Full Article Transmembrane Prostatic Acid Phosphatase (TMPAP) Delays Cells in G1 Phase of the Cell Cycle Researchers report that the stable overexpression of transmembrane prostatic acid phosphatase (TMPAP), but not the secreted isoform in LNCaP cells reduces cell growth while increasing endo/exocytosis and cell size. Specifically, cells overexpressing TMPAP accumulate in the G1 phase of the cell cycle, and show altered gene expression profile. [Prostate] Abstract Analysis of TMEFF2 Allografts and Transgenic Mouse Models Reveals Roles in Prostate Regeneration and Cancer Previous results indicated a tumor suppressor role for the transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) in prostate cancer. Here, scientists further characterized this role and uncovered new functions for TMEFF2 in cancer and adult prostate regeneration. [Prostate] Abstract Osteopontin Splice Variants Expression Is Involved on Docetaxel Resistance in PC3 Prostate Cancer Cells Researchers investigated some cellular mechanisms by which osteopontin splice variants could mediate PC3 prostate cancer cell survival and growth in response to docetaxel-induced cell death. [Tumor Biol] Abstract Brassinin Combined with Capsaicin Enhances Apoptotic and Anti-Metastatic Effects in PC-3 Human Prostate Cancer Cells Researchers analyzed the potential synergistic anti-tumor effects of brassinin combined with capsaicin on prostate cancer PC-3 cells. [Phytother Res] Abstract CLINICAL RESEARCH OLIGOPELVIS – GETUG P07: A Multicenter Phase II Trial of Combined Salvage Radiotherapy and Hormone Therapy in Oligometastatic Pelvic Node Relapses of Prostate Cancer Investigators assessed the two year outcome in oligometastatic prostate cancer patients treated concomitantly with high-dose intensity-modulated radiation therapy and androgen-deprivation therapy for six months. [BMC Cancer] Full Article |