LABORATORY RESEARCH Specific Myosins Control Actin Organization, Cell Morphology, and Migration in Prostate Cancer Cells The authors investigated the myosin expression profile in prostate cancer cell lines and found that Myo1b, Myo9b, Myo10, and Myo18a were expressed at higher levels in cells with high metastatic potential. [Cell Rep] Full Article | Graphical Abstract Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model Researchers analyzed whether the potential anticancer effects of nimbolide, a limonoid triterpene derived from Azadirachtaindica, against prostate cancer cell lines and transgenic adenocarcinoma of mouse prostate model are mediated through the negative regulation of STAT3 pathway. [Antioxid Redox Signal] Abstract Low β2-Adrenergic Receptor Level May Promote Development of Castration Resistant Prostate Cancer and Altered Steroid Metabolism To elucidate mechanisms by which β2-adrenergic receptor (ADRB2) may affect castration-resistant prostate cancer development, investigators stably transfected LNCaP cells with shRNAs to mimic low and high expression of ADRB2. Two UDP-glucuronosyltransferases, UGT2B15 and UGT2B17, involved in phase II metabolism of androgens, were strongly downregulated in two LNCaP shADRB2 cell lines. [Oncotarget] Full Article Expression of Beta-Defensin 131 Promotes an Innate Immune Response in Human Prostate Epithelial Cells Researchers investigated the role of β-defensin 131 (DEFB131) in RWPE-1 cells during bacterial infection. They examined the intracellular signaling pathways and nuclear responses in RWPE-1 cells that contribute to DEFB131 gene induction upon stimulation with lipoteichoic acid. [PLoS One] Full Article miR-195 Inhibits EMT by Targeting FGF2 in Prostate Cancer Cells The role of miR-195 in migration and invasion in vitro was investigated, and common markers in epithelial-mesenchymal transition (EMT) were evaluated through Western blot analysis. A luciferase reporter assay was conducted to confirm the target gene of miR-195 were validated in prostate cancer cells. [PLoS One] Full Article HDAC6 Activity Is Not Required for Basal Autophagic Flux in Metastatic Prostate Cancer Cells Scientists characterized the histone deacetylase 6-interacting proteins in LNCaP metastatic prostate cancer cells and found that histone deacetylase 6 interacts with proteins involved in several cellular processes, including autophagy. [Exp Biol Med] Abstract Apoptosis of Human Prostate Cancer Cells Induced by Marine Actinomycin X2 through the mTOR Pathway Compounded by MiRNA144 Scientists determined whether actinomycin X2 intercepted the mTOR/PTEN/PI3K/Akt signaling pathway to inhibit human prostate cancer cells in vitro. [Anticancer Drugs] Abstract CLINICAL RESEARCH Randomized Double-Blind Trial of Pregabalin versus Placebo in Conjunction With Palliative Radiotherapy for Cancer-Induced Bone Pain Investigators examined pregabalin in patients with cancer-induced bone pain receiving radiotherapy. A multicenter, double-blind randomized trial of pregabalin versus placebo was conducted. [J Clin Oncol] Abstract |