Prostate Cell News Volume 6.48 | Dec 18 2015

Exosomes from Bulk and Stem Cells from Human Prostate Cancer Have a Differential MicroRNA Content that Contributes Cooperatively over Local and Pre-Metastatic Niche
Five prostate cancer primary cell cultures were established to originate bulk and cancer stem cells cultures. From them, exosomes were purified by precipitation for miRNAs extraction to perform a comparative profile of miRNAs by next generation sequencing in an Illumina platform. [Oncotarget] Full Article

Fibroblasts Prolong Serum Prostate-Specific Antigen Decline after Androgen Deprivation Therapy in Prostate Cancer
Scientists investigated the role of fibroblasts in serum prostate-specific antigen decline after androgen deprivation therapy. They performed in vitro experiments using androgen-sensitive, androgen receptor-positive prostate epithelial cell lines, commercially available prostate stromal cells, and primary cultures of prostate fibroblasts. [Lab Invest] Abstract

Exosomal Particles Secreted by Prostate Cancer Cells Are Potent mRNA and Protein Vehicles for the Interference of Tumor and Tumor Environment
Researchers characterized the mRNA and protein composition as well as cellular functions of prostate cancer cell-derived exosomes. Exosomes were prepared from prostate cancer cell culture supernatant by ultracentrifugation and subsequently characterized by dynamic light scattering and electron microscopy. [Prostate] Abstract

Oxidative Stress Resistance in Metastatic Prostate Cancer: Renewal by Self-Eating
Investigators explored resistance mechanisms in the advanced type of prostate cancer cells and aimed to clarify the role of autophagy in these processes. [PLoS One] Full Article

Malformin A₁ Promotes Cell Death through Induction of Apoptosis, Necrosis and Autophagy in Prostate Cancer Cells
Investigators reported the mode of mechanism underlying malformin A₁-mediated cytotoxicity through induction of apoptosis, necrosis and autophagy in prostate cancer cells. [Cancer Chemother Pharmacol] Abstract

Knockdown of GPR137,G Protein-Coupled Receptor 137, Inhibits the Proliferation and Migration of Human Prostate Cancer Cells
To see whether GPR137 could serve as a potential therapeutic target for prostate cancer (CaP), GPR137 was knocked down to verify its biological function in CaP cells. The authors found that silencing of the GPR137 gene suppressed the proliferation and colony formation of CaP cell lines PC-3 and DU145. [Chem Biol Drug Des] Abstract

Quercetin Inhibits Angiogenesis through Thrombospondin-1 Upregulation to Antagonize Human Prostate Cancer PC-3 Cell Growth In Vitro and In Vivo
The authors explored the important role of thrombospondin-1 upregulation in reducing angiogenesis and anti-prostate cancer effect of quercetin both in vitro and in vivo for the first time. [Oncol Rep] Abstract

CLINICAL RESEARCH

Long-Term Outcome of a Phase II Trial Using Immunomodulatory In Situ Gene Therapy in Combination with Intensity-Modulated Radiotherapy with or without Hormonal Therapy in the Treatment of Prostate Cancer
Investigators report the long-term outcome of a Phase II trial of immune-modulatory in situ gene therapy in combination with intensity-modulated radiotherapy with or without hormonal therapy for the treatment of prostate cancer. [J Radiat Oncol] Abstract | Press Release

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Regen BioPharma, Inc. Identifies Small Molecule Drug Candidates Targeting Its Proprietary Immune Checkpoint NR2F6
Regen BioPharma, Inc. announced identification of a series of compounds that have been identified by biochemical testing which interact with the company’s newly identified immune checkpoint NR2F6. Previously, the company reported that the use of gene silencing of NR2F6 leads to induction of cancer stem cell differentiation, a process that renders malignant cancer cells benign. [Regen BioPharma, Inc. (PR Newswire Association LLC)] Press Release

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NEW Professorship – Oncogenic Pathways (German Cancer Research Center)

NEW Professor Position – Cancer Immunotherapy (City of Hope)

PhD Student – Cancer Research (German Cancer Research Center)

Postdoctoral Research Fellow – Cell Cycle Control and Tumorigenesis (Fred Hutchinson Cancer Research Center)

Postdoctoral Positions – Prostate Cancer (Baylor College of Medicine)

Postdoctoral Position – Molecular Cancer Biology (University of Pennsylvania)

Investigator – Cancer Biology (Wake Forest Baptist School of Medicine)

Group Leader Position – Cancer Research (Oslo University Hospital)

Division Head – Medical Oncology (Fred Hutchinson Cancer Research Center)

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