LABORATORY RESEARCH The Role of Mesenchymal Stem Cells in Promoting the Transformation of Androgen-Dependent Human Prostate Cancer Cells into Androgen-Independent Manner Researchers investigated the underlying mechanism of mesenchymal stem cells in promoting prostate cancer cells from androgen-dependent into androgen-independent manner. [Sci Rep] Full Article Microbubble-Mediated Ultrasound Promotes Accumulation of Bone Marrow Mesenchymal Stem Cell to the Prostate for Treating Chronic Bacterial Prostatitis in Rats A therapeutic-ultrasound apparatus was used to treat the prostate in the presence of circulating microbubbles and bone marrow mesenchymal stem cells (BMMSCs). The BMMSC distribution was assessed with in vivo imaging, and the prostate structure with light microscopy. [Sci Rep] Full Article Signaling Network Controlling Androgenic Repression of c-Fos in Prostate Adenocarcinoma Cells The authors showed that androgens suppress c-Fos protein and mRNA expression induced by 12-O-tetradecanoylphorbol-13-acetate or epidermal growth factor in human prostate cancer cell lines. [J Biol Chem] Abstract | Full Article Texas Native Plants Yield Compounds with Cytotoxic Activities against Prostate Cancer Cells Three Texas native plants yielded three new and three known compounds with antiproliferative and cytotoxic activities against prostate cancer cells with IC50 values in the range of 1.7-35.0 μM. [J Nat Prod] Abstract AXIN2 Expression Predicts Prostate Cancer Recurrence and Regulates Invasion and Tumor Growth Low AXIN2 expression was associated with prostate cancer (PCa) recurrence after radical prostatectomy in a test population as well as in external validation cohorts, and its expression levels in PCa cells significantly impacted invasiveness, proliferation, and tumor growth. [Prostate] Abstract ΔNp63α Transcriptionally Regulates the Expression of CTEN that Is Associated with Prostate Cell Adhesion The study demonstrated that ΔNp63 and C-terminal tensin-like (CTEN) are both highly expressed in normal prostate epithelial cells and are down-regulated in prostate cancer. In addition, reduced expression of CTEN and ΔNp63 was correlated with prostate cancer progression from primary tumors to metastatic lesions. [PLoS One] Full Article A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion Scientists designed a high-content assay to discover drugs that block peripheral lysosome trafficking with the goal of identifying novel drugs that inhibit tumor cell invasion. An automated high-content imaging system was used to measure the position of lysosomes relative to the nucleus. [PLoS One] Full Article CLINICAL RESEARCH Association between Statins and Clinical Outcomes Among Men with Prostate Cancer: A Systematic Review and Meta-Analysis A systematic review found that statin significantly reduced the all-cause and prostate cancer-specific mortality and improved the biochemical recurrence in certain subgroup of men with prostate cancer. [Prostate Cancer Prostatic Dis] Abstract Greater Extent of Prostate Inflammation in Negative Biopsies Is Associated with Lower Risk of Prostate Cancer on Repeat Biopsy: Results from the REDUCE Study In a cohort of men undergoing repeat prostate biopsy 2 years after a negative baseline biopsy, a greater extent of baseline acute prostate inflammation and chronic prostate inflammation was independently associated with lower prostate cancer risk. [Prostate Cancer Prostatic Dis] Abstract |