LABORATORY RESEARCH Potential Role for YB-1 in Castration-Resistant Prostate Cancer and Resistance to Enzalutamide through the Androgen Receptor V7 Researchers aimed to elucidate the kinome in castration-resistant prostate cancer as well as the role of key molecules. [J Natl Cancer Inst] Abstract Integration of Lipidomics and Transcriptomics Unravels Aberrant Lipid Metabolism and Defines Cholesteryl Oleate as Potential Biomarker of Prostate Cancer Scientists performed lipidomics and transcriptomics in paired prostate cancer tumor and adjacent nontumor tissues, followed by external validation of biomarker candidates. [Sci Rep] Full Article Role of Protease-Activated Receptor 2 in the Development of Lower Urinary Tract Dysfunction Researchers reported that the mast cell-tryptase-protease-activated receptor 2 (PAR2) axis plays a critical role in the development of chronic pain in experimental autoimmune prostatitis, a mouse model of chronic prostatitis/chronic pelvic pain syndrome. They therefore examined whether PAR2 activation mediates lower urinary tract dysfunction. [J Urol] Abstract Prostate Cancer-Derived Cathelicidin-Related Antimicrobial Peptide Facilitates Macrophage Differentiation and Polarization of Immature Myeloid Progenitors to Protumorigenic Macrophages To investigate protumorigenic role(s) of cathelicidin-related antimicrobial peptide (CRAMP), a murine orthologue of leucin leucin 37, investigators compared tumor growth kinetics between mouse prostate cancer cell lines with and without CRAMP expression in immunocompetent mice. [Prostate] Abstract CLINICAL RESEARCH The Use of a Gas Chromatography-Sensor System Combined With Advanced Statistical Methods, Towards the Diagnosis of Urological Malignancies Researchers proposed a gas chromatography-sensor algorithm system for classifying urine samples from patients with urological symptoms. The pilot study included 155 men presenting to urology clinics, 58 were diagnosed with prostate cancer, 24 with bladder cancer and 73 with hematuria and or poor stream, without cancer. [J Breath Res] Abstract | Press Release The ERSPC Risk Calculators Significantly Outperform the PCPT 2.0 in the Prediction of Prostate Cancer; a Multi-Institutional Study To analyze the performance of the Prostate Cancer Prevention Trial Risk Calculator (PCPT-RC) and two iterations of the European Randomized Study of Screening for Prostate Cancer Risk Calculator (ERSPC-RC), one of which incorporates prostate volume and another which incorporates prostate volume and the Prostate Health Index in a referral population. [BJU Int] Abstract The Prognostic Impact of Serum Testosterone during Androgen-Deprivation Therapy in Patients with Metastatic Prostate Cancer and the SRD5A2 Polymorphism Scientists investigated the relationship between androgen-deprivation therapy (ADT) serum testosterone levels or body mass index and the prognosis among men treated with primary ADT for metastatic prostate cancer. [Prostate Cancer Prostatic Dis] Abstract Stratification of Aggressive Prostate Cancer from Indolent Disease-Prospective Controlled Trial Utilizing Expression of 11 Genes in Apparently Benign Tissue Investigators evaluated the diagnostic power of molecular markers in men with a clinical suspicion of prostate cancer using apparently benign areas as targeted by magnetic resonance imaging. [Urol Oncol] Abstract |