LABORATORY RESEARCH Interaction of EGFR to Delta-Catenin Leads to Delta-Catenin Phosphorylation and Enhances EGFR Signaling Scientists investigated the possible correlation between epidermal growth factor receptor (EGFR) and δ-catenin in prostate cancer cells. They found that EGFR interacted with δ-catenin and the interaction decreased in the presence of EGF. [Sci Rep] Full Article Increased Expression of Fibroblast Growth Factor 13 (FGF13) in Prostate Cancer Is Associated with Shortened Time to Biochemical Recurrence after Radical Prostatectomy Researchers examined the FGF13 expression pattern in human prostate cancer specimens and evaluated its potential as a biomarker for patient outcome after radical prostatectomy. [Int J Cancer] Abstract UHRF1 Overexpression Is Involved in Cell Proliferation and Biochemical Recurrence in Prostate Cancer after Radical Prostatectomy UHRF1 was overexpressed in almost all of the prostate cancer (PCa) cell lines. In PCa cells, UHRF1 knockdown inhibited cell proliferation and migration, and induced apoptosis. [J Exp Clin Cancer Res] Full Article Diet-Induced Alteration of Fatty Acid Synthase in Prostate Cancer Progression The authors investigated the role of fatty acid synthase on prostate cancer (PCa) progression in LNCaP xenograft mice fed with high-fat diet or low-fat diet, in PCa cells, and in clinical PCa. [Oncogenesis] Full Article Relative Cytotoxic Potencies and Cell Death Mechanisms of α1-Adrenoceptor Antagonists in Prostate Cancer Cell Lines PC-3 and LNCap human prostate cancer cells were exposed to α1-adrenoceptor antagonists and cell survival assessed after 24-72 hr. The levels of apoptosis, autophagy and stress related proteins were also determined. [Prostate] Abstract Epidermal Growth Factor Induces P38 MAPK-Dependent G0/G1-to-S Transition in Prostate Cancer Cells upon Androgen Deprivation Conditions Investigators showed that, in LNCaP cells, androgen deprivation induces arrest in the G0/G1 cell cycle phase, and that epidermal growth factor partially rescues this arrest without affecting cell death. [Growth Factors] Abstract Tumor Growth Kinetics before and after First-Line Chemotherapy in Metastatic Castration-Resistant Prostate Cancer: A Prostate-Specific Antigen-Based Retrospective Analysis The authors assessed whether some prostate-specific antigen-related variables of tumor cell kinetics predict the overall survival in early and late metastatic castration-resistant prostate cancer, and to explore changes in the tumor growth fraction after chemotherapy. [Am J Clin Oncol] Abstract Interactive Effects of 9-cis-Retinoic Acid and Androgen on Proliferation, Differentiation, and Apoptosis of LNCaP Prostate Cancer Cells LNCaP and PC-3 cells were cultured and treated with a range of 9-cis-retinoic acid (9cRA) concentrations for 3-6 days in the absence or presence of 5α-dehydrotestosterone. 9cRA inhibited cell proliferation in a dose-dependent manner, plateauing at 10 mol/l. [Eur J Cancer Prev] Abstract CLINICAL RESEARCH Abiraterone Acetate for Metastatic Castration-Resistant Prostate Cancer after Docetaxel Failure: A Randomized, Double-Blind, Placebo-Controlled Phase III Bridging Study Scientists evaluated the efficacy and safety of abiraterone acetate-prednisone versus placebo-prednisone in Asian metastatic castration-resistant prostate cancer patients who have failed docetaxel-based chemotherapy. [Int J Urol] Abstract |