LABORATORY RESEARCH ErbB2 Signaling Increases Androgen Receptor Expression in Abiraterone-Resistant Prostate Cancer Investigators assessed ErbB2 activity in abiraterone-resistant prostate cancer, and determined whether it may contribute to androgen receptor signaling in these tumors. [Clin Cancer Res] Abstract Dietary Pterostilbene Is a Novel MTA1-Targeted Chemopreventive and Therapeutic Agent in Prostate Cancer Researchers determined metastasis-associated protein 1 (MTA1)-targeted chemopreventive and therapeutic efficacy of pterostilbene, a natural potent analog of resveratrol, in pre-clinical models of prostate cancer. [Oncotarget] Full Article Edelfosine Promotes Apoptosis in Androgen Deprived Prostate Tumors by Increasing ATF3 and Inhibiting Androgen Receptor Activity Researchers investigated the effects of edelfosine combined with androgen deprivation in LNCaP and VCaP human prostate cancer cells. [Mol Cancer Ther] Abstract Androgen Deprivation in LNCaP Prostate Tumor Xenografts Induces Vascular Changes and Hypoxic Stress, Resulting in Promotion of Epithelial-to-Mesenchymal Transition Scientists hypothesised that an initial treatment response that increases tumor hypoxia drives selection of more malignant tumors. [Br J Cancer] Abstract MiR-185 Attenuates Androgen Receptor Function in Prostate Cancer Indirectly by Targeting Bromodomain Containing 8 Isoform 2, an Androgen Receptor Co-Activator Scientists studied interactions between miR-185 and the bromodomain containing 8 isoform 2 (BRD8 ISO2) to investigate indirect mechanisms of miR-185 with respect to androgen receptor function through BRD8 ISO2 in prostate cancer. [Mol Cell Endocrinol] Abstract The Androgen Receptor Regulates PPARγ Expression and Activity in Human Prostate Cancer Cells Investigators examined whether the androgen receptor (AR) regulates peroxisome proliferator activated receptor gamma (PPARγ) expression and function within human prostate cancer cells. qRT-PCR and Western blot analyses revealed nanomolar concentrations of the AR agonist dihydrotestosterone decrease PPARγ mRNA and protein within the castration-resistant, AR-positive C4-2 and VCaP human prostate cancer cell lines. [J Cell Physiol] Abstract PCA3 Long Noncoding RNA Modulates the Expression of Key Cancer-Related Genes in LNCaP Prostate Cancer Cells To further comprehend the mechanisms by which prostate cancer antigen 3 (PCA3) modulates LNCaP cell survival, researchers characterized the expression patterns of several cancer-related genes, including those involved in epithelial-mesenchymal transition and androgen receptor cofactors in response to PCA3 silencing. [Tumour Biol] Abstract CLINICAL RESEARCH TMPRSS2-ERG in Blood and Docetaxel Resistance in Metastatic Castration-Resistant Prostate Cancer The authors evaluated TMPRSS2-ERG expression using quantitative reverse transcription polymerase chain reaction in peripheral blood mononuclear cells and tumor tissue from metastatic resistant prostate cancer patients treated with taxanes. They examined peripheral blood mononuclear cells from 24 healthy controls, 50 patients treated with docetaxel, and 22 with cabazitaxel. [Eur Urol] Abstract |