Prostate Cell News Volume 7.10 | Mar 18 2016

An Epigenetic Reprogramming Strategy to Re-Sensitize Radioresistant Prostate Cancer Cells
Investigators showed that irradiating prostate cancer cells stimulates a durable upregulation of stem cell markers that epigenetically reprogram these cells. [Cancer Res] Abstract

C/EBPβ Regulates Sensitivity to Bortezomib in Prostate Cancer Cells by Inducing REDD1 and Autophagosome-Lysosome Fusion
Researchers investigated whether C/EBPβ, a transcription factor involved in the control of autophagic gene expression, regulates resistance to proteasome inhibition. [Cancer Lett] Abstract

Prostate-Derived Ets Factor Represses Tumorigenesis and Modulates Epithelial-to-Mesenchymal Transition in Bladder Carcinoma Cells
In a comparison between normal urothelium and bladder tumor tissue, the authors identified significant decreases of prostate-derived Ets (E-twenty six) factor (PDEF) in the tumor tissue. The immunohistochemistry assays indicated a significantly higher immunostaining of PDEF in low-grade bladder tumors. [Cancer Lett] Abstract

Graviola Inhibits Hypoxia-Induced NADPH Oxidase Activity in Prostate Cancer Cells Reducing Their Proliferation and Clonogenicity
Scientists report that NADPH oxidase (NOX) expression is directly associated with prostate cancer (PCa) progression in TRAMP mice, suggesting NOX as a potential chemoprevention target in controlling PCa. [Sci Rep] Full Article

Novel Roles for Class II Phosphoinositide 3-Kinase C2β in Signaling Pathways Involved in Prostate Cancer Cell Invasion
Researchers showed that phosphoinositide 3-kinases-class II subfamily regulates mitogen-activated protein kinase kinase and extracellular signal-regulated kinase activation in prostate cancer cells. [Sci Rep] Full Article

12-HETER1/GPR31, a High-Affinity 12(S)-Hydroxyeicosatetraenoic Acid Receptor, Is Significantly Up-Regulated in Prostate Cancer and Plays a Critical Role in Prostate Cancer Progression
Researchers have determined the distribution of 12-HETER1/GPR31 in prostate cancer tissue and its role in prostate tumorigenesis using in vitro and in vivo assays. [FASEB J] Abstract

Phosphatase of Regenerating Liver 3 (PRL-3) Is Overexpressed in Human Prostate Cancer Tissue and Promotes Growth and Migration
The authors investigated the expression of PRL-3 mRNA in fresh-frozen samples from patients undergoing radical prostatectomy because of prostate cancer and the biological function of PRL-3 in prostate cancer cells. [J Transl Med] Full Article

CLINICAL RESEARCH

Pre-Diagnostic Circulating Sex Hormone Levels and Risk of Prostate Cancer by ERG Tumour Protein Expression
The authors examined associations between pre-diagnostic circulating levels of total testosterone, free testosterone, DHT, androstanediol glucuronide, estradiol, and SHBG and risk of prostate cancer by TMPRSS2:ERG status. [Br J Cancer] Abstract

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MedCom GmbH and Hitachi Medical Systems Europe Announce an Agreement to Distribute BiopSee^®
MedCom GmbH and Hitachi Medical Systems announce an agreement to distribute through Hitachi’s subsidiaries sales network in Europe BiopSee^®, MedCom’s fusion imaging system for stereotactic, navigated, targeted prostate biopsy & therapy guidance, for use in conjunction with Hitachi ultrasound systems. [Hitachi Medical Systems] Press Release

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NEW Lead Scientist – Prostate Cancer (Memorial Sloan Kettering Cancer Center)

NEW Postdoctoral Fellowship – Castration Resistant Prostate Cancer (University of Florida)

Postdoctoral Fellowship – Optical Imaging of Prostate Cancer (CEA Tech)

PhD Studentship – Wnt Signaling in Stem Cells and Cancer (German Cancer Research Center)

PhD Studentship – Genome Sequencing Technologies in Prostate Cancer (University of East Anglia)

PhD Studentship – Aggressive Prostate Cancer (University of East Anglia)

Postdoctoral Fellowship – Prostate and Breast Cancer Molecular Mechanisms (Feinberg School of Medicine)

Tenure Track Faculty Positions – Various Methods in Cancer Biology (Paul L. Foster School of Medicine)

Postdoctoral Fellowship – Epidemiology of Prostate Cancer (Fred Hutchinson Cancer Research Center)

Research Group Leader – Stress Regulated Processes During Oncogenesis (INSERM)

Postdoctoral Fellowship – Cancer Epigenomics (Princess Margaret Cancer Centre)

Postdoctoral Fellowship – Prostate Cancer Biology (Medical University of South Carolina )

Postdoctoral Fellowship – Prostate Cancer and Cancer Metabolism (Cleveland Clinic)

Post-Doc Fellowship – Metastasis of Cancer (University of Arizona Cancer Center)

Postdoctoral Research Fellow – Cell Cycle Control and Tumorigenesis (Fred Hutchinson Cancer Research Center)

Division Head – Medical Oncology (Fred Hutchinson Cancer Research Center)

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