LABORATORY RESEARCH CACUL1 Functions as a Negative Regulator of Androgen Receptor in Prostate Cancer Cells Scientists report that CDK2-associated cullin 1 (CACUL1) directly associates with androgen receptor (AR) and suppresses AR transcriptional activity. In addition, CACUL1 represses histone demethylase LSD1-mediated AR transactivation by competing with LSD1 for AR binding. [Cancer Lett] Abstract Long Non-Coding RNAs Harboring miRNA Seed Regions Are Enriched in Prostate Cancer Exosomes Investigators characterized the expression of long non-coding RNAs (lncRNAs) in several prostate cancer exosomes and their parental cell lines. They showed that certain lncRNAs are enriched in cancer exosomes with the overall expression signatures varying across cell lines. [Sci Rep] Full Article Toward the Optimization of Bombesin-Based Radiotracers for Tumor Targeting The effect of residue and backbone modification on several parameters such as the internalization of radiolabeled peptides into PC3 and AR42J tumor cells, their affinity toward the human gastrin-releasing peptide receptor (GRPr), metabolic stability in blood plasma, and biodistribution in mice bearing GRPr-expressing PC3 xenografts was studied. [J Med Chem] Abstract Basal Progenitors Contribute to Repair of the Prostate Epithelium Following Induced Luminal Anoikis Researchers showed that anoikis of luminal cells in the prostate epithelium is followed by a program of tissue repair that is mediated in part by differentiation of basal epithelial cells to luminal cells. [Stem Cell Reports] Full Article | Graphical Abstract Regulation of E3 Ubiquitin Ligase-1 (WWP1) by MicroRNA-452 Inhibits Cancer Cell Migration and Invasion in Prostate Cancer Expression of microRNA-452 (miR-452) was significantly downregulated in prostate cancer (PCa) tissues. Transfection with mature miR-452 inhibited the migration and invasion of PCa cells. [Br J Cancer] Abstract Computational Reconstruction of NFκB Pathway Interaction Mechanisms during Prostate Cancer The authors provide the first steps toward computational reconstruction of interaction mechanisms of the nuclear-factor-kappa-B (NFκB) pathway in prostate cancer. They identified novel roles for ATF3, CXCL2, DUSP5, JUNB, NEDD9, SELE, TRIB1, and ZFP36 in this pathway, in addition to new mechanistic interactions between these genes and ten known NFκB pathway members. [Plos Comput Biol] Full Article Amplification of the 9p13.3 Chromosomal Region in Prostate Cancer The authors investigated the 9p13.3 amplification in more detail to identify genes that are potentially advantageous for cancer cells. They narrowed down the minimally amplified area and assessed the frequency of the 9p13.3 amplification. [Genes Chromosomes Cancer] Abstract An Original Patient-Derived Xenograft of Prostate Cancer with Cyst Formation Scientists established a unique patient-derived xenograft model to identify biomarkers for treatment efficacy and resistance and better understand prostate cancer biology. [Prostate] Abstract Equol Inhibits Prostate Cancer Growth via Degradation of the Androgen Receptor by Skp2 Among soy isoflavones, equol suppressed androgen receptor as well as prostate-specific antigen expression most potently in androgen-dependent LNCaP cells. However, the inhibitory effect on androgen receptor expression and activity was less prominent in castration-resistant CxR and 22Rv1 cells. [Cancer Sci] Abstract CLINICAL RESEARCH Radioligand Therapy with 177Lu-PSMA-617 as a Novel Therapeutic Option in Patients with Metastatic Castration Resistant Prostate Cancer The authors evaluated tumor response, adverse effects, and survival in patients undergoing radioligand therapy with 177Lu-prostate-specific membrane antigen (PSMA)-617. [Clin Nucl Med] Abstract |