LABORATORY RESEARCH TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer The authors showed that recurrent prostate cancer (PC)-driver mutations in speckle-type POZ protein stabilize the TRIM24 protein, which promotes proliferation under low androgen conditions. TRIM24 augments androgen receptor (AR) signaling, and AR and TRIM24 co-activated genes are significantly upregulated in castration-resistant PC. [Cancer Cell] Abstract | Graphical Abstract The Metabolic Co-Regulator PGC1α Suppresses Prostate Cancer Metastasis Scientists showed that the transcriptional co-activator peroxisome proliferator-activated receptor gamma co-activator 1α (PGC1α) suppresses prostate cancer progression and metastasis. [Nat Cell Biol] Abstract | Press Release Inhibition of the Hexosamine Biosynthetic Pathway Promotes Castration-Resistant Prostate Cancer Scientists showed distinct alterations in the hexosamine biosynthetic pathway (HBP) to be critical for castration-resistant prostate cancer (CRPC). Expression of HBP enzyme glucosamine-phosphate N-acetyltransferase 1 is found to be significantly decreased in CRPC compared with localized prostate cancer. [Nat Commun] Full Article | Press Release The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis Researchers report that Map3k7 deletion in mouse prostate cells sensitizes to cell death by TNF-related apoptosis-inducing ligand. Surprisingly, this death occurred primarily through necroptosis, not apoptosis, due to assembly of the necrosome in association with the autophagy machinery, mediated by p62/SQSTM1 recruitment of RIPK1. [Dev Cell] Abstract | Graphical Abstract Histone Deacetylase Inhibition in Prostate Cancer Triggers miR-320-Mediated Suppression of the Androgen Receptor Histone deacetylase (HDAC) alters the epigenetic status of tumor-associated genes, including those for microRNAs (miRNAs), and affects the behavior of cancers. Researchers examined the molecular effects of a HDAC inhibitor, OBP-801, on androgen receptor expression and tumor cell growth in prostate cancers. [Cancer Res] Abstract BAP18 Coactivates Androgen Receptor Action and Promotes Prostate Cancer Progression Investigators demonstrated that BPTF associated protein of 18 kDa (BAP18) is identified as a coactivator of androgen receptor (AR) in the Drosophila experimental system and mammalian cells. BAP18 facilitated the recruitment of MLL1 subcomplex and AR to androgen-response element of AR target genes, subsequently increasing histone H3K4 trimethylation and H4K16 acetylation. [Nucleic Acids Res] Full Article Zoledronic Acid Impairs Stromal Reactivity by Inhibiting M2-Macrophages Polarization and Prostate Cancer-Associated Fibroblasts The authors unraveled a novel anti-tumor activity of zoledronic acid (ZA) in prostate cancer (PCa), by targeting the pro-tumorigenic properties of both stromal and immune cells. They demonstrated that ZA impairs PCa-induced M2-macrophages polarization, reducing their pro-invasive effect on tumor cells and their pro-angiogenic features. [Oncotarget] Full Article Regulation of miR-200c and miR-141 by Methylation in Prostate Cancer Increasing evidence shows that aberrant epigenetic regulation of miRNAs is a contributing factor to their altered expression in cancer. The authors investigated whether expression of miR-200c and miR-141 in prostate cancer is related to the DNA methylation status of their promoter. [Prostate] Abstract CLINICAL RESEARCH PMH 9907: Long-Term Outcomes of a Randomized Phase III Study of Short-Term Bicalutamide Hormone Therapy and Dose-Escalated External-Beam Radiation Therapy for Localized Prostate Cancer The authors report the long-term outcome of a Phase III study of dose-escalated external-beam radiotherapy with or without hormone therapy for patients with localized prostate cancer. [Cancer] Abstract A Circulating miRNA Assay as a First-Line Test for Prostate Cancer Screening Scientists analyzed the levels of circulating microRNAs (miRNAs) in patients with elevated prostate-specific antigen who were diagnosed with either localized prostate cancer or benign prostatic hyperplasia upon biopsy. Real-time RT–PCR with Taqman probes was used to measure plasma levels of miRNAs. [Br J Cancer] Abstract Independent Validation of the Prognostic Capacity of the ISUP Prostate Cancer Grade Grouping System for Radiation Treated Patients with Long-Term Follow-Up In a large independent radiotherapy cohort with long-term follow-up, investigators have validated the biochemical recurrence-free survival (bRFS) benefit of the proposed five-tier grade grouping system. [Prostate Cancer Prostatic Dis] Abstract |