Prostate Cell News Volume 7.21 | Jun 10 2016

TOP STORY

PROTAC-Induced BET Protein Degradation as a Therapy for Castration-Resistant Prostate Cancer

The authors showed that ARV-771, a small-molecule pan-bromodomain and extra-terminal (BET) degrader based on proteolysis-targeting chimera (PROTAC) technology, demonstrates dramatically improved efficacy in cellular models of castration-resistant prostate cancer as compared with BET inhibition. [Proc Natl Acad Sci USA] Abstract | Full Article

(Ranked by impact factor of the journal)

LABORATORY RESEARCH

MicroRNA-101 Regulated Transcriptional Modulator SUB1 Plays a Role in Prostate Cancer

Scientists showed that microRNA-101 targets transcriptional coactivator SUB1 homolog/positive cofactor 4 and regulates its expression. SUB1 is known to have diverse role in vital cell processes such as DNA replication, repair and heterochromatinization. [Oncogene] Full Article

A ZEB1-miR-375-YAP1 Pathway Regulates Epithelial Plasticity in Prostate Cancer

Investigators demonstrated that microRNA-375 (miR-375) is inversely correlated with epithelial–mesenchymal transition signatures in clinical samples and can drive mesenchymal–epithelial transition in model systems. Indeed, miR-375 potently inhibited invasion and migration of multiple prostate cancer lines. [Oncogene] Abstract

Carnosic Acid Promotes Degradation of the Androgen Receptor and Is Regulated by the Unfolded Protein Response Pathway In Vitro and In Vivo

Researchers demonstrated that carnosic acid, a benzenediol diterpene, binds the LBD of the androgen receptor (AR) and degrades the AR via ER stress mediated proteasomal degradative pathway. In vitro, carnosic acid treatment induced degradation of AR and decreased expression of PSA in human prostate cancer cell lines LNCaP and 22Rv1. [Carcinogenesis] Abstract

PBX3 Is a Putative Biomarker of Aggressive Prostate Cancer

The potential of pre-B cell leukemia homeobox 3 PBX3 to predict prognosis, either at mRNA or protein level, was studied in four independent cohorts. PBX3 was mainly expressed in the nucleus of normal prostate basal cells, while it showed cytosolic expression in prostatic intraepithelial neoplasia and cancer cells. [Int J Cancer] Abstract

KAT8 Regulates Androgen Signaling in Prostate Cancer Cells

Scientists demonstrated an epigenetic crosstalk between histone modifications and androgen receptor (AR) target gene regulation. They discovered that KAT8, a member of the MYST family of histone acetyltransferases that catalyzes histone H4 lysine 16 acetylation, co-localized with WDR5 at AR-target genes, resulting in hormone-dependent gene activation in prostate cancer cells. [Mol Endocrinol] Abstract

Characterization of Fibroblast-Free CWR-R1ca Castration-Recurrent Prostate Cancer Cell Line

The authors sought to establish and characterize a fibroblast-free derivative of the CWR-R1 cell line. The CWR-R1ca cell line was established from CWR-R1 cells by removing fibroblasts using multiple cycles of short-term trypsinization, cloning, and pooling single-cell colonies. [Prostate] Abstract

Regulation of Metastasis-Promoting LOXL2 Gene Expression by Antitumor MicroRNAs in Prostate Cancer

Using luciferase reporter assays, scientists showed that the lysyl oxidase-like 2 (LOXL2) gene was directly controlled by these tumor-suppressive microRNAs in prostate cancer (PCa) cells. Overexpression of LOXL2 was confirmed in PCa tissues and knockdown of the LOXL2 gene markedly inhibited the migration and invasion of PCa cells. [J Hum Genet] Abstract

CLINICAL RESEARCH

Association of AR-V7 on Circulating Tumor Cells as a Treatment-Specific Biomarker with Outcomes and Survival in Castration-Resistant Prostate Cancer

To determine if pretherapy nuclear androgen-receptor splice variant 7 (AR-V7) protein expression and localization on circulating tumor cells is a treatment-specific marker for response and outcomes between androgen receptor signaling inhibitors and taxanes. [JAMA Oncol] Abstract | Press Release

The Roles of MicroRNAs in the Progression of Castration-Resistant Prostate Cancer

The authors summarize the current knowledge about microRNAs regulating prostate cancer progression and elucidate the mechanism of progression to castration-resistant prostate cancer. [J Hum Genet] Abstract

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Bayer and Orion Expand Clinical Development Program with New Phase III Study ARASENS for BAY-1841788 (ODM-201) in Prostate Cancer

Bayer and Orion Corporation announced the expansion of the global clinical development program for the investigational androgen receptor antagonist BAY-1841788 in the area of prostate cancer. [Bayer AG] Press Release

Sophiris Bio Reports Successful Results from Completed Phase IIa Study of Topsalysin in Localized Prostate Cancer

Sophiris Bio Inc. announced the biopsy results from all 18 patients enrolled in the Phase IIa proof of concept study of topsalysin in localized prostate cancer. [Sophiris Bio Inc.] Press Release

NEW Gordon Research Conference – Tissue Niches & Resident Stem Cells in Adult Epithelia
August 7-12, 2016
Hong Kong, China

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NEW Postdoctoral Fellow – Signaling and Epigenetic Regulation (Medical University of South Carolina)

Research Technologist – Mammary and Prostate Stem Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Prostate Cancer and Metabolism (Cleveland Clinic)

PhD Studentship – Bioinformatics to Classify Prostate Cancer (University of East Anglia)

Research Associate – Prostate Cancer (University of Cambridge)

Postdoctoral Fellow – Cell Cycle Regulation in Prostate and Pancreatic Cancer (Purdue University)

Postdoctoral Fellow – Cancer Genomics (Henry Jackson Foundation)

Postdoctoral Fellow – Mechanisms of Castrate Resistance (University of Chicago)

Postdoctoral Research Fellow – Molecular Epidemiology of Cancer (Fred Hutchinson Cancer Research Center)

Postdoctoral Fellow – Genetic Determinants of Cancer (Memorial Sloan-Kettering Cancer Center)

Postdoctoral Fellow – Prostate Cancer (Cleveland Clinic)

Postdoctoral Fellow – Prostate Epithelial Homeostasis and Carcinogenesis (Baylor College of Medicine)

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