Prostate Cell News Volume 7.22 | Jun 17 2016

TOP STORY

Targeting Oct1 Genomic Function Inhibits Androgen Receptor Signaling and Castration-Resistant Prostate Cancer Growth

Oct1 polyamides suppressed castration-resistant tumor growth and specifically repressed global Oct1 chromatin association and androgen signaling in prostate cancer cells, with few nonspecific effects on basal promoter activity. [Oncogene] Abstract

(Ranked by impact factor of the journal)

LABORATORY RESEARCH

Mesenchymal Stem Cells Are Recruited and Activated into Carcinoma-Associated Fibroblasts by Prostate Cancer Microenvironment-Derived TGF-β1

The authors investigated the signaling molecules which regulate the interplay between mesenchymal stem cells, prostate carcinoma cells and two important cellular types constituting the tumor-associated stroma, macrophages and fibroblasts, during their progression towards malignancy. [Stem Cells] Abstract

High Expression of TROP2 Characterizes Different Cell Subpopulations in Androgen-Sensitive and Androgen-Independent Prostate Cancer Cells

Investigators found that treatment of mice bearing LNCaP-derived xenograft tumors with cytotoxic and anti-androgen compounds enriched for cells that express TROP2, a putative tumor-initiating cell marker. [Oncotarget] Full Article

TMPRSS2-ERG Fusion Protein Regulates Insulin-Like Growth Factor-1 Receptor (IGF1R) Gene Expression in Prostate Cancer: Involvement of Transcription Factor Sp1

Scientists showed that TMPRSS2-ERG mediates its tumorigenic effects through regulation of IGF1R gene expression. Silencing of T-ERG in VCaP cells resulted in downregulation of both IGF1R and Sp1, a critical IGF1R regulator. [Oncotarget] Abstract

A Novel Crosstalk between the Tumor Suppressors ING1 and ING2 Regulates Androgen Receptor Signaling

Investigators showed that surprisingly the inhibitor of growth 1 (ING)1b knockdown represses androgen receptor (AR)-mediated transactivation on AR key target genes in the human LNCaP prostate cancer cells. [J Mol Med] Abstract

GATA3-Driven Expression of miR-503 Inhibits Prostate Cancer Progression by Repressing ZNF217 Expression

Scientists found that microRNA-503 (miR-503) was significantly downregulated in advanced prostate cancer (PCa) tissues and cell lines. Downregulation of miR-503 was strongly associated with aggressive clinical-pathological features and poor prognosis in PCa patients. [Cell Signal] Abstract

Measuring the Effects of Fractionated Radiation Therapy in a 3D Prostate Cancer Model System Using SERS Nanosensors

The authors showed that they can monitor loss of viability by measuring pH and redox potential in multicellular tumor spheroids and furthermore they demonstrated that Surface Enhanced Raman Spectroscopy (SERS) can be used to measure the effects of fractionation of a dose of radiotherapy in a way that has potential to inform treatment planning. [Analyst] Abstract

Tubeimoside-1 Induces Oxidative Stress-Mediated Apoptosis and G₀/G₁ Phase Arrest in Human Prostate Carcinoma Cells In Vitro

Researchers investigated the anticancer activity and molecular targets of tubeimoside-1 in human prostate cancer cells in vitro. [Acta Pharmacol Sin] Abstract

The Investigation of Minoxidil-Induced [Ca²⁺]_i Rises and Non-Ca²⁺-Triggered Cell Death in PC3 Human Prostate Cancer Cells

Researchers explored the effect of minoxidil on cytosolic-free Ca²⁺ levels and cell viability in PC3 human prostate cancer cells. [J Recept Signal Transduct Res] Abstract

CLINICAL RESEARCH

Randomized, Double-Blind, Placebo-Controlled Phase III Study of Tasquinimod in Men with Metastatic Castration-Resistant Prostate Cancer

Tasquinimod, a novel oral therapy targeting the tumor microenvironment, significantly improved progression-free survival in a randomized, placebo-controlled Phase II trial in men with metastatic castration-resistant prostate cancer. This Phase III study was conducted to confirm the Phase II results and to detect an overall survival benefit. [J Clin Oncol] Abstract

Androgen Receptor Targeted Therapies in Castration-Resistant Prostate Cancer: Bench to Clinic

The authors present an overview of androgen receptor-related mechanisms of resistance as well as novel therapeutic agents to overcome resistance that is linked to the expression of androgen receptor splice variants in castration-resistant prostate cancer. [Int J Urol] Abstract

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Zenith Announces Dosing of First Patient in Phase I Clinical Trial and Corporate Update Webcast Details

Zenith Epigenetics Corp. announced that it has dosed the first patient in its Phase I clinical trial for ZEN-3694 in metastatic castration resistant prostate cancer patients. [Zenith Epigenetics Corp. (PR Newswire Association LLC.)] Press Release

Decatur Memorial Hospital Announces Groundbreaking Imaging Technology Available to Patients with Prostate Cancer

After completing a two-year clinical trial to detect prostate cancer in earlier stages, Decatur Memorial Hospital is now offering C-11 Choline PET CT and MRI to patients who have biochemical relapse of prostate cancer. [Decatur Memorial Hospital (PR Newswire Association LLC.)] Press Release

NEW International Conference on Stem Cell Engineering 2016
October 23-26, 2016
Toronto, Canada

Visit our events page to see a complete list of events in the prostate cell community.

NEW Postdoctoral Fellow – Cancer Research (University of California – San Francisco)

Research Technologist – Mammary and Prostate Stem Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Signaling and Epigenetic Regulation (Medical University of South Carolina)

Postdoctoral Fellow – Prostate Cancer and Metabolism (Cleveland Clinic)

PhD Studentship – Bioinformatics to Classify Prostate Cancer (University of East Anglia)

Postdoctoral Fellow – Cell Cycle Regulation in Prostate and Pancreatic Cancer (Purdue University)

Postdoctoral Fellow – Cancer Genomics (Henry Jackson Foundation)

Postdoctoral Fellow – Mechanisms of Castrate Resistance (University of Chicago)

Postdoctoral Fellow – Prostate Epithelial Homeostasis and Carcinogenesis (Baylor College of Medicine)

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