Prostate Cell News Volume 7.41 | Nov 4 2016

TOP STORY

Structure and Function of a Prostate Cancer Dissemination Permissive Extracellular Matrix

Scientists investigated the structure and function of an extracellular matrix that facilitates prostate cancer metastasis by comparing orthotopic tumors that frequently metastasize, to poorly metastatic subcutaneous tumors. [Clin Cancer Res] Abstract

(Ranked by impact factor of the journal)

LABORATORY RESEARCH

HER2 and EGFR Overexpression Support Metastatic Progression of Prostate Cancer to Bone

Researchers evaluated the expression of HER2 protein in metastatic samples obtained from prostate cancer patients and investigated the functional significance of HER2 and EGFR overexpression in the osseous growth of human prostate cancer cells in vivo. [Cancer Res] Abstract | Full Article

An Interaction with Ewing’s Sarcoma Breakpoint Protein EWS Defines a Specific Oncogenic Mechanism of ETS Factors Rearranged in Prostate Cancer

Researchers investigated the role of the wild-type EWS protein in the oncogenic mechanism of ETS genes rearranged in prostate cancer. [Cell Rep] Full Article | Press Release | Graphical Abstract

Combination of Sorafenib and Enzalutamide as a Potential New Approach for the Treatment of Castration-Resistant Prostate Cancer

Investigators studied the efficacy of sorafenib combined with enzalutamide in a castration-resistant prostate cancer model and explored a potential strategy to improve enzalutamide efficacy in vitro and in LNCaP xenografts. [Cancer Lett] Abstract

P110β Inhibition Reduces Histone H3K4 Di-Methylation in Prostate Cancer

The authors determined the role of phosphoinositide 3-kinase signaling in histone methylation in prostate cancer, with emphasis on histone H3K4 methylation. [Prostate] Abstract

Expression of Netrin-1 by Hypoxia Contributes to the Invasion and Migration of Prostate Carcinoma Cells by Regulating YAP Activity

The authors investigated the role of netrin-1 in hypoxic metastasis potential of prostate carcinoma. [Exp Cell Res] Abstract

A Novel Physiological Glycosaminoglycan-Deficient Splice Variant of Neuropilin-1 Is Anti-Tumorigenic In Vitro and In Vivo

Researchers identified and studied a so far uncharacterized splice variant of neuropilin-1 (NRP1), NRP1-Δ7. To investigate the biological properties of this isoform, they generated prostatic and breast cancer cells able to express recombinant NRP1 or NRP1-Δ7 in a doxycycline-inducible manner. [PLoS One] Full Article

A New Transgenic Mouse Model for Conditional Overexpression of the Polycomb Group Protein EZH2

Prostate-specific Ezh2 overexpression by crossbreeding with Probasin-Cre mice led to neoplastic prostate lesions at low incidence and with a long latency. Compounding a previously described Bmi1-transgene and Pten-deficiency prostate cancer mouse model with the Ezh2 transgene did not enhance tumour progression or drive metastasis formation. [Transgenic Res] Abstract

CLINICAL RESEARCH

Functional Variants of the 5-Methyltetrahydrofolate-Homocysteine Methyltransferase Gene Significantly Increase Susceptibility to Prostate Cancer: Results from an Ethnic Han Chinese Population

In this hospital-based case-control study of 1817 prostate cancer (PCa) cases and 2026 cancer-free controls, scientists genotyped six polymorphisms in three one-carbon metabolism genes and assessed their association with the risk of PCa. [Sci Rep] Full Article

Correlation of B7-H3 with Androgen Receptor, Immune Pathways and Poor Outcome in Prostate Cancer: An Expression-Based Analysis

Investigators used genomic expression data to examine the relationship between B7-H3 mRNA expression and prostate cancer. [Prostate Cancer Prostatic Dis] Abstract

Prostate Cancer: Developing Novel Approaches to Castration-Sensitive Disease

This review outlines new developments and investigational strategies for the treatment of castration-sensitive prostate cancer. [Cancer] Abstract

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

Genomic Health Announces Positive Topline Clinical Validation Study Results Demonstrating Oncotype DX^® Prostate Cancer Test Predicts Risk of Metastasis and Mortality

Genomic Health, Inc. announced topline results from a large clinical validation study of its biopsy-based Oncotype DX^® Genomic Prostate Score™. The study, performed in collaboration with a large integrated healthcare system, met its primary endpoint by demonstrating that the multi-gene Oncotype DX^® test, assessed in prostate needle biopsy tumor tissue, is a strong predictor of the development of metastasis and prostate cancer death in patients with early-stage prostate cancer. [Genomic Health, Inc.] Press Release

P4 Diagnostix Laboratory Network Announces Acquisition of Metamark Laboratories

P4 Diagnostix™ Laboratory Network announced the acquisition of Metamark Laboratories, Inc., formerly a division of Metamark Genetics, Inc. Sathish Reddy, CEO, stated “all P4 laboratory divisions will work closely and act as distribution partners for MetaMark Genetics’ novel biomarker assays, including ProMark^®, the first proteomic classifier of biopsied prostate tissue that assesses whether an early-stage prostate tumor is aggressive or indolent, aiding important treatment decisions.” [P4 Diagnostix (PR Newswire Association LLC)] Press Release

Pioneering Drug Discovery Company Bridge Medicines Launched to Advance Promising Early Technologies in Major Academic Institutions through Human Proof of Concept

Memorial Sloan Kettering Cancer Center, The Rockefeller University and Weill Cornell Medicine announced that they have established a new drug discovery company called Bridge Medicines. [Memorial Sloan Kettering Cancer Center] Press Release

Russian Science at the Crossroads

As the United States goes to the polls after an unprecedentedly vulgar election campaign, its former cold-war rival is exuding strength and confidence. Just last week, Russia cited its proud history of exploration and science in Antarctica when giving the green light to an international agreement to create a vast marine reserve in the Ross Sea. [Nature News] Editorial

Tracker Flags Up Failures to Report Clinical Trials

An automated tool has trawled through thousands of records on the world’s leading clinical-trials database to reveal which drug firms and academic institutions are failing to publish the results of their trials. The US Department of Health and Human Services announced tougher rules to push the researchers that it funds to publish clinical-trial designs and results. [Nature News] Editorial

Publisher Pulls 58 Articles by Iranian Scientists over Authorship Manipulation

A tranche of 58 articles authored by 282 Iran-based researchers were retracted by a leading scientific publisher, which said it had found signs that the peer review and publication processes had been compromised. [Nature News] Editorial

Young Scientists Ditch Postdocs for Biotech Start-Ups

There is a vanguard of young biomedical scientists who have started companies instead of taking the conventional academic path and pursuing postdoctoral studies after their PhDs. Among the factors driving this change are an infusion of money into early-stage biotech investing, the emergence of biotech incubators and the scarcity of academic jobs in science. [Nature News] Editorial

Beyond Trump vs Clinton: A Scientist’s Guide to the US Election

Choices that voters make will influence other levels of government — and some of these decisions will steer the course of science and science policy. [Nature News] Editorial

NEW 2017 European Cancer Congress
January 27-30, 2017
Amsterdam, Netherlands

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow – Molecular Biophysics (Institute for Research in Biomedicine)

NEW Postdoctoral Scholar – Cancer Nanomedicine (Vanderbilt University)

Postdoctoral Researcher – Prostate Cancer Genomics (The Ohio State University)

Postdoctoral Fellow – Pharmacogenomics Prostate Cancer (Moffitt Cancer Center)

Postdoctoral Fellow – Prostate Cancer Biology (Weill Cornell Medicine)

Bioinformatician – Prostate Cancer (University of Oxford)

Bioinformatics – Postdoctoral Research Fellow (Institute of Cancer Research)

Postdoctoral Fellowships – Prostate Disease (Cleveland Clinic Lerner Research Institute)

Postdoctoral Position – Prostate Cancer Genomics (The Ohio State University, College of Pharmacy)

Postdoctoral Fellow – Prostate Cancer Biology (University of Maryland)

Research Intern – Prostate Cancer (Fred Hutchinson Cancer Research Center)

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