Prostate Cell News 8.00 January 6, 2017 | |
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TOP STORYScientists demonstrated that Rb1 loss facilitates lineage plasticity and metastasis of prostate adenocarcinoma initiated by Pten mutation. Additional loss of Trp53 causes resistance to antiandrogen therapy. [Science] Abstract | Press Release | Video | |
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PUBLICATIONS(Ranked by impact factor of the journal)LABORATORY RESEARCHInvestigators showed that an intrinsic constitutively activated feedforward signaling circuit composed of IκBα/NF-κB(p65), miR-196b-3p, Meis2, and PPP3CC is formed during the emergence of castration-resistant prostate cancer (CRPC). This circuit controls the expression of stem cell transcription factors that drives the high tumorigenicity of CRPC cells. [Mol Cell] Abstract | Press Release | Graphical Abstract Hollow Boron Nitride Nanospheres as Boron Reservoir for Prostate Cancer Treatment Researchers report on hollow boron nitride (BN) spheres with controlled crystallinity and boron release that decrease cell viability and increase prostate cancer cell apoptosis. In vivo experiments on subcutaneous tumor mouse models treated with BN spheres demonstrated significant suppression of tumor growth. An orthotopic tumor growth model was also utilized and further confirmed the in vivo anti-cancer efficacy of BN spheres. [Nat Commun] Full Article CD54-NOTCH1 Axis Controls Tumor Initiation and Cancer Stem Cell Functions in Human Prostate Cancer Investigators implemented a novel chemoresistant prostate cancer patient-derived xenograft model in NOD/SCID mice and identified CD54 as a candidate gene among the most highly enriched gene expression profiles in prostate tumors exposed to chronic cisplatin administration. Additional in vitro and in vivo assays showed that CD54 played a critical role in the self-renewal and tumorigenesis of prostate cancer stem cells. [Theranostics] Full Article The authors introduced a device capable of the concurrent detection of cellular and molecular markers from a single sample fluid. They presented a device which achieves affinity as well as size-based separation of captured targets using antibody-conjugated magnetic beads and a silicon chip containing micro-apertures. Using LNCaP cells and prostate specific membrane antigen (PSMA) to model prostate cancer, the device was able to detect 34 pM of spiked PSMA and achieve a cell capture efficiency of 93% from culture media. [Lab Chip] Abstract | Graphical Abstract Through a multi ‘omics’ approach scientists defined the heme oxygenase 1 (HO-1) interactome in prostate cancer (PCa), identifying HO-1 molecular partners associated with the integrity of the cellular cytoskeleton. Under HO-1 induction, PCa cells present reduced frequency in migration events, trajectory and cell velocity and, a significant higher proportion of filopodia-like protrusions favoring zippering among neighboring cells. Moreover forced expression of HO-1 was also capable of altering cell protrusions in transwell co-culture systems of PCa cells with MC3T3 cells. [Cell Death Dis] Full Article Secreted Heat Shock Protein 90 Promotes Prostate Cancer Stem Cell Heterogeneity eHsp90 targeting attenuates tumor invasion and metastasis, supporting its unique role in tumor progression. Researchers herein investigated the potential role of eHsp90 as a modulator of cancer stem-like cells in prostate cancer (PCa). They reported a novel function for eHsp90 as a facilitator of PCa stemness, determined by its ability to upregulate stem-like markers, promote self-renewal, and enhance prostasphere growth. [Oncotarget] Full Article Investigators found that the expression level of miR-218 was down-regulated in the human prostate cancer specimens. Moreover, overexpression of miR-218 inhibited cell viability, migration and invasion in PC3 and DU145 cells. [Mol Carcinog] Abstract Potent EMT and CSC Phenotypes Are Induced by Oncostatin-M in Pancreatic Cancer The authors demonstrated the capacity of oncostatin M to regulate an epithelial-mesenchymal transition (EMT)/cancer stem cell (CSC) plasticity program that promotes tumorigenic properties in relation to pancreatic ductal adenocarcinoma. [Mol Cancer Res] Abstract CLINICAL RESEARCHBy genome-wide DNA methylome profiling, scientists sought to identify new biomarkers to improve the accuracy of prostate cancer diagnosis and prognosis. [Oncotarget] Full Article | |
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REVIEWSIn this review, the authors focus on the role played by the protein partners of ligand-activated extranuclear androgen receptor in the final effects of hormone action, such as proliferation, migration and neuritogenesis. [FASEB J] Abstract Exosomal MicroRNAs in Liquid Biopsies: Future Biomarkers for Prostate Cancer The authors summarize the diagnostic and prognostic utility of exosomal miRNAs in prostate cancer. [Clin Transl Oncol] Abstract Visit our reviews page to see a complete list of reviews in the prostate cell research field. | |
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INDUSTRY NEWSMinomic Announces Clinical Study Update for MILGa in Prostate, Bladder and Pancreatic Cancers Minomic International Ltd. announced that it has completed enrollment and dosing of the first three patients in its pioneering clinical trial of MILGa, a chimeric version of Minomic’s MIL-38 anti-Glypican 1 antibody conjugated to the radioactive isotope 67Gallium. [Minomic International Ltd. (Business Wire, Inc.)] Press Release Arno Therapeutics Announces Update to Onapristone Prostate Cancer Development Program Arno Therapeutics, Inc. announced that it has concluded not to enroll the remaining three patients in the company’s ongoing Phase II clinical trial of onapristone in combination with Zytiga® in men with advanced castration-resistant prostate cancer who have failed Zytiga alone. [Arno Therapeutics, Inc. (Business Wire, Inc.)] Press Release | |
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POLICY NEWSUS Scientists Fear New Restrictions on Fetal-Tissue Research House Republicans conclude that tissue from aborted fetuses is of limited value for research and seek to reduce funding. [Nature News] Editorial Argentina’s Researchers Occupy Science Ministry Hundreds of young researchers occupied Argentina’s science ministry in Buenos Aires last month, angry at budget cuts that they say have denied them permanent jobs at the country’s National Scientific and Technical Research Council. The occupation was the most extreme action yet by Argentinian scientists after months of protests at last year’s budget, the first under President Mauricio Macri. And the occupation seems to have paid off, in part: many of those involved have been offered extensions to their fellowships. [Nature News] Editorial Scientists in Germany, Peru and Taiwan to Lose Access to Elsevier Journals Thousands of scientists in Germany, Peru and Taiwan are preparing for a new year without online access to journals from the Dutch publishing giant Elsevier. Contract negotiations in both Germany and Taiwan broke down in December, while Peru’s government has cut off funding for a licence. [Nature News] Editorial
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EVENTSNEW 19th International AEK Cancer Congress Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Prostate Cancer (European Molecular Biology Laboratory (EMBL)) NEW Head of Department – Cancer Genetics (Oslo University Hospital) Associate Member – Stem Cell/Gene Therapy (Fred Hutchinson Cancer Research Center) Postdoctoral Researcher – Prostate Cancer (Icahn School of Medicine at Mount Sinai) Postdoctoral Researcher – Prostate Carcinogenesis (The University of Alabama) Postdoctoral Researcher – Prostate Cancer (Cleveland Clinic Lerner Research Institute) Postdoctoral Fellow – Molecular Oncology (Institute of Oncology Research) Faculty Position – Cancer Immunology (University of New Mexico School of Medicine) Faculty Position – Cancer Immunology (University of New Mexico) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Prostate Cell News Volume 8.00 | Jan 6 2017