Prostate Cell News Volume 8.07 | Feb 24 2017

TOP STORY

Researchers Identify ‘Achilles’ Heel’ of PTEN That Helps Drive Prostate Cancer Progression

Researchers have discovered that a protein called Importin-11 protects the anti-cancer protein PTEN from destruction by transporting it into the cell nucleus. They suggest that the loss of Importin-11 may destabilize PTEN, leading to the development of lung, prostate, and other cancers. [Press release from Cold Spring Harbor Laboratory discussing online prepublication in J Cell Biol] Press Release | Abstract

(Ranked by impact factor of the journal)

Targeting DNA Damage Response in Prostate Cancer by Inhibiting Androgen Receptor-CDC6-ATR-Chk1 Signaling

Researchers found that cell division cycle 6 (CDC6) expression is increased during prostate cancer progression and positively correlates with androgen receptor (AR) in prostate cancer tissues. AR or CDC6 knockdown, together with AZD7762, a Chk1/2 inhibitor, resulted in decreased TopBP1-ATR-Chk1 signaling and markedly increased ataxia-telangiectasia-mutated phosphorylation, a biomarker of DNA damage, and synergistically increased treatment efficacy. [Cell Rep] Full Article | Graphical Abstract

Efficacy of Photochemical Internalization Using Disulfonated Chlorin and Porphyrin Photosensitizers: An In Vitro Study in 2D and 3D Prostate Cancer Models

Investigators assessed the potential of photochemical internalization with two different photosensitizers in prostate cancer cells using standard 2D monolayer culture and 3D biomimetic model. They showed that PC3 cells exhibited a higher uptake than MatLyLu cells for both photosensitizers. [Cancer Lett] Full Article

Identification of Protein Biomarkers and Signaling Pathways Associated with Prostate Cancer Radioresistance Using Label-Free LC-MS/MS Proteomic Approach

Investigators identified differential proteins and signaling pathways from parental prostate cancer (CaP) cell lines and CaP radioresistant (RR) sublines using a label-free LC-MS/MS proteomics approach. A total of 309 signaling pathway proteins were identified to be significantly altered between CaP and CaP-RR cells. [Sci Rep] Full Article

Chrysin Induces Death of Prostate Cancer Cells by Inducing ROS and ER Stress

The authors investigated functional roles of chrysin in progression of prostate cancer cells using DU145 and PC-3 cell lines. The results showed that chrysin induced apoptosis of cells evidenced by DNA fragmentation and increasing the population of both DU145 and PC-3 cells in the sub-G₁ phase of the cell cycle. [J Cell Physiol] Abstract

TCF7 Is Suppressed by the Androgen Receptor via microRNA-1-Mediated Downregulation and Is Involved in the Development of Resistance to Androgen Deprivation in Prostate Cancer

Scientists aimed to determine the role of transcription factor 7 (TCF7), a transcription factor best known as a Wnt effector that forms a complex with β-catenin, in the development of advanced prostate cancer. They demonstrated a molecular mechanism of androgen receptor signaling suppressing TCF7 partly through microRNA-1-mediated downregulation. [Prostate Cancer Prostatic Dis] Abstract

Elevation of SHARPIN Protein Levels in Prostate Adenocarcinomas Promotes Metastasis and Impairs Patient Survivals

Researchers analyzed the expression of SHANK-associated RH domain interacting protein (SHARPIN) in prostate cancer tissues from 95 patients and its relationship with other clinical characteristics associated with PCA malignancies and patient survivals, and examined the impacts of SHARPIN suppression with siRNA on proliferation, angiogenesis, invasion, and expression levels of MMP-9 of prostate cancer cells and metastasis to lung by these cells in nude mice. [Prostate] Abstract

Androgen Receptor Splice Variants Are Not Substrates of Nonsense-Mediated Decay

The authors first used siRNA knockdown of the nonsense-mediated decay (NMD) regulator, UPF1, in an NMD reporter assay to determine if this surveillance pathway was functioning normally in androgen receptor (AR) variant-expressing cell lines. They then used UPF1 knockdown to determine if expression of the AR variants ARV3 and ARV7 is affected by inhibition of NMD. They found that the NMD pathway functions normally in the AR variant-expressing cell line 22Rv1 and that inhibition of NMD does not increase expression of ARV3 or ARV7. [Prostate] Abstract

MTA1-Activated Epi-MicroRNA-22 Regulates E-Cadherin and Prostate Cancer Invasiveness

Scientists identified microRNA (miR)-22 as an epigenetic (epi)-miR directly induced by metastasis-associated protein 1 (MTA1) and predicted to target E-cadherin. Loss-of-function and overexpression studies of MTA1 reinforced its regulatory role in miR-22 expression. [FEBS Lett] Abstract

Silica Nanostructured Platform for Affinity Capture of Tumor-Derived Exosomes

Prostate-specific membrane antigen (PSMA) was highly enriched in exosomes excreted by PSMA⁺ prostate cancer cells. Using PSMA⁺ cells from the well-established prostate cancer cell line (LNCaP), the secreted exosomes were collected and isolated from the culture medium. [J Mt Sci] Abstract | Press Release

Meta-Analysis of Metabolic Syndrome and Prostate Cancer

Researchers aimed to evaluate the impact of metabolic syndrome (MetS) and MetS factors on prostate cancer (PCa) incidence, on the risk of high-grade PCa and to analyze the role of MetS and single MetS components on the development of aggressive PCa features. [Prostate Cancer Prostatic Dis] Abstract

Visit our reviews page to see a complete list of reviews in the prostate cell research field.

OncoGenex Pharmaceuticals, Inc. Announces Phase II Apatorsen Data for Two Clinical Trials Presented

OncoGenex Pharmaceuticals, Inc. announced that apatorsen results from two randomized Phase II clinical trials were presented. Clinical data from trials in bladder and prostate cancers demonstrated apatorsen was well-tolerated and improved patient outcomes when administered in combination with standard-of-care treatments. [Press release from OncoGenex Pharmaceuticals, Inc. discussing research presented at the American Society of Clinical Oncology (ASCO) 2017 Genitourinary Cancers Symposium, Orlando] Press Release

Algae Dynamics Corp. Announces Research Agreement With University of Waterloo to Investigate Use of Cannabis Oil in the Context of Cancer

Algae Dynamics Corp. announced a research agreement with the University of Waterloo to perform fundamental research on cannabis oil and its constituents in the context of the development and treatment of cancers of the colorectum, pancreas, breast and prostate. [Algae Dynamics Corp.] Press Release

The Scripps Research Institute Announces New Board Members and Chairman of the Board

The Scripps Research Institute announced the appointment of nine new members to its Board of Directors, including John D. Diekman, who will serve as chairman of the board. Diekman replaces Richard A. Gephardt, who is retiring from the board after seven years of service. [The Scripps Research Institute] Press Release

Updated: Will They or Won’t They? What Science Groups Are Saying About Joining the March for Science

The March for Science is creating a buzz in the scientific community. The march arose as a grassroots reaction to concerns about the conduct of science under President Donald Trump. And it has spurred debate over whether it will help boost public support for research, or make scientists look like another special-interest group, adding to political polarization. [Science Insider] Editorial

Firing of Veteran NIH Scientist Prompts Protests over Publication Ban

At least two dozen junior and senior researchers are stuck in scientific limbo after being barred from publishing data collected over a 25-year period at a National Institutes of Health (NIH) lab. The unusual ban follows the firing last summer of veteran neurologist Allen Braun by the National Institute on Deafness and Other Communication Disorders for what many scientists have told Science are relatively minor, if widespread, violations of his lab’s experimental protocol. [ScienceInsider] Editorial

NEW American Society of Gene & Cell Therapy (ASGCT)
May 10-13, 2017
Washington, DC, United States

Visit our events page to see a complete list of events in the community.

NEW Assistant/Associate Professor – Urology (Northwestern University)

NEW Postdoctoral Position – Genomics and Molecular Biology (The George Washington University)

PhD Studentships – Translational Research Network for Prostate Cancer (University of Glasgow)

Clinical Research Fellow – Oncogenetics (Institute of Cancer Research)

Postdoctoral Researcher – Confocal Raman Spectroscopy and Digital Holographic Microscopy (Maynooth University)

Postdoctoral Fellow – RNA Biology (Thomas Jefferson University)

Postdoctoral Researcher – Prostate Cancer Immunotherapy (University of Chicago)

Postdoctoral Fellow – Prostate Cancer Biology (Weill Cornell Medicine)

Postdoctoral Fellow – Prostate/Pancreatic Cancer (Medical College of Wisconsin)

Postdoctoral Fellowship – Translational Cancer Disparities Research (Duke Cancer Institute)

Assistant Professor – Molecular Therapeutics of Cancer (Dartmouth College / Geisel School of Medicine)

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